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Report for SNP rs1260326

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 The Effectiveness of a Mediterranean Diet Intervention in NAFLD Clinical Course

The effects of Mediterranean Diet (MedDiet) on clinical, biochemical and inflammatory profile in NAFLD patients with simple steatosis. Potential associations of single nucleotide polymorphisms to diet composition and patients' profile were also investigated.

NCT03203486 NAFLD Steatosis of Liver Other: Mediterranean Diet
MeSH: Non-alcoholic Fatty Liver Disease Fatty Liver
HPO: Hepatic steatosis

Furthermore, genotyping of STAT3 rs2293152 and GCKR rs1260326 single nucleotide polymorphisms takes place.

Primary Outcomes

Description: A decrease in liver fat

Measure: Regulation of hepatic steatosis

Time: Change from Baseline to 6 months

Secondary Outcomes

Description: Increase in MedDietScore

Measure: Adherence to MedDiet

Time: Change from Baseline to 6 months

Description: Decrease in visfatin levels

Measure: Regulation of visfatin

Time: Change from Baseline to 6 months

Description: Decrease in oxLDL levels

Measure: Regulation of oxLDL

Time: Change from Baseline to 6 months

Description: Decrease in visfatin in carriers of the risk allele

Measure: Association of single nucleotide polymorphisms to response to dietary treatment

Time: Change from Baseline to 6 months


HPO Nodes


Hepatic steatosis
Genes 137
ATP7B LDLRAP1 MPV17 CLPB APOE APOB SLC40A1 POLG HNF1B COA8 ABCG8 BSCL2 HFE GPD1 BCS1L CIDEC ACAD9 LYRM4 AGPAT2 LMNA LMNB2 PRDM16 CAV1 FOS LMNA TYMP LIPE RERE BCS1L MPV17 BSCL2 CIDEC MCCC1 ACADM PLIN1 SLC25A13 HADHB ETFA CAV1 XRCC4 CPT1A FBP1 PCK1 PTRH2 CEP19 RMND1 LMNA GABRD POLR3A TMEM199 NSMCE2 PPARG ADK ACAD9 LIPA TFAM NGLY1 PMM2 HNRNPA1 VPS33A AKT2 POLD1 MARS1 DDOST TRAPPC11 ETFB ACADVL BSCL2 ALMS1 LMNA LARS1 CPT2 CBS CARS2 COX15 NDUFAF1 LRPPRC ALDOB PCSK9 HNRNPA2B1 TRMU PGM1 NSMCE2 CPT2 LIPE ACOX1 LDLR CYP7A1 MRPL44 PCK2 DNAJC19 LMNA FARSB ABHD5 CAVIN1 PNPLA2 HADH ZMPSTE24 ETFDH ALMS1 PNPLA2 SLC22A5 PHKG2 AGPAT2 DGUOK ATP6AP1 COG6 ABHD5 HADHA PHKA2 SLC40A1 TARS2 LMNA TRAPPC11 PPARG MRPS7 KCNAB2 ACADL HADH SLC25A13 ACADM VCP HNF4A PLIN1 PPARG EARS2 SAR1B CAVIN1 SLC25A13 HSD17B4 DNAJC19 RRM2B SKI CYP19A1 IARS1 POLG ABCG5