SNPMiner Trials by Shray Alag


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Report for SNP rs2987983

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Can Dietary Phytoestrogens Slow Down Prostate Tumor Proliferation? A Randomized Study (PRODICA)

The purpose of this study is to evaluate if a diet with a high content of phytoestrogens can slow down the prostate tumor proliferation. Phytoestrogens are found in food items such as soy, rye, and seeds. Two hundred thirty men with prostate cancer will be included in the study and followed until surgery (at least 6 weeks). Half of the study participants will receive general information about healthy food choices and a package of foods with high content of phytoestrogens to add to their food. The other half will get the same information but not receive the food-package.

NCT02759380 Prostate Cancer Other: Phytoestrogen-rich foods
MeSH: Prostatic Neoplasms
HPO: Prostate cancer Prostate neoplasm

The men will be divided into two subgroups, those bearing TT or TC/CC alleles, of the single-nucleotide polymorphism (SNP) rs2987983-13950 T/C in the ERß-gene, in which the hypothesis will be tested.

The investigators found in earlier studies that approximately 42 % of the male population are heterozygous or homozygous for the variant allele (TC/CC) of the ERβ promoter region SNP (rs2987983-13950 T/C) and 58 % homozygous for the wild type allele (TT).

Primary Outcomes

Description: Ki-67 is measured in tumor cells which are obtained from specimens from the prostate.

Measure: Percentage of positive stained cells with Ki-67

Time: The specimens will be obtained first from a biopsy from when the prostate cancer is found, the other biopsy is obtained after radical prostatectomy surgery. Approximate time between the first and second biopsy is 3-6 months.

Secondary Outcomes

Measure: PSA-levels

Time: Blood samples obtained at baseline and at day before surgery.


HPO Nodes


Prostate cancer
Genes 32
RNASEL TP53 RNF43 PTEN BARD1 RAD50 BRCA2 NBN BMPR1A BRCA1 NAB2 CDH1 RAD51C MXI1 PALB2 EPHB2 CHEK2 BRCA2 BRIP1 GREM1 MRE11 CHEK2 RAD51 ZFHX3 MAD1L1 TP53 RAD51D AR STAT6 PTEN APC KLF6