SNPMiner Trials (Home Page)
Report for SNP rs4129267
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
There are 2 clinical trials
Clinical Trials
1 Molecular, Cytological Features and Genetic Susceptibility of Occupational Chronic Obstructive Pulmonary Disease Attributable to Different Environmental Exposures
The objective of this study is to investigate molecular, cytological and genetic features of occupational chronic obstructive pulmonary disease (COPD) in conditions of different occupational exposures. In order to achieve this goal serum pro-inflammatory cytokines and standard inflammation markers level, hemostasis, cytological analysis of bronchoalveolar lavage and associations of single nucleotide polymorphisms (SNPs) rs1800470 transforming growing factor β1 (TGF β1) gene, rs1828591 hedgehog interacting protein (HHIP) gene, rs4129267 interleukin 6 receptor (IL-6R) gene, rs1051730 nicotinic acetylcholine receptor 3 (CHRNA3) gene with COPD in subjects exposed to silica dust and in those exposed to polycyclic aromatic hydrocarbons exhaust will be investigated. The relationship between genotype and phenotype characteristics, such as an inflammation activity, assessed by C-reactive protein (hsCRP) and tumor necrosis factor-α (TNF α) serum concentration, in different occupational COPD groups will be studied. The hypothesis is that the mechanisms underlying disease development and progression are different due to environmental risk factor that reflex in differs in disease attributes - molecular biomarkers, cytology results and genetic susceptibility between COPD due to dust, COPD due to chemicals and COPD in smokers therefore COPD can be subdivided into ecological phenotypes according to environmental risk factor.
NCT02220387 Chronic Obstructive Pulmonary Disease Other: exposure to respirable silica dust Other: exposure to polycyclic aromatic hydrocarbons exhaust MeSH: Lung Diseases Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Genetic Predisposition to Disease
HPO: Abnormal lung morphology Chronic obstructive pulmonary disease Obstructive lung disease
In order to achieve this goal serum pro-inflammatory cytokines and standard inflammation markers level, hemostasis, cytological analysis of bronchoalveolar lavage and associations of single nucleotide polymorphisms (SNPs) rs1800470 transforming growing factor β1 (TGF β1) gene, rs1828591 hedgehog interacting protein (HHIP) gene, rs4129267 interleukin 6 receptor (IL-6R) gene, rs1051730 nicotinic acetylcholine receptor 3 (CHRNA3) gene with COPD in subjects exposed to silica dust and in those exposed to polycyclic aromatic hydrocarbons exhaust will be investigated.
Association of SNPs rs1800470 TGF β1 gene, rs1828591 HHIP gene, rs4129267 IL-6R gene, rs1051730 CHRNA3 gene with COPD in subjects exposed to dust and in those exposed to chemicals.. Odds ratio and 95% confidence interval will be calculated for each occupational group.
Primary Outcomes
Description: Odds ratio and 95% confidence interval will be calculated for each occupational group. Controls - healthy people.
Measure: Association of SNPs rs1800470 TGF β1 gene, rs1828591 HHIP gene, rs4129267 IL-6R gene, rs1051730 CHRNA3 gene with COPD in subjects exposed to dust and in those exposed to chemicals. Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in cytological analysis of bronchoalveolar lavage fluid results between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in serum interleukin 1 beta (IL-1β) level between COPD patients exposed to dust, chemicals and tobacco smoke. Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in serum TNFα level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in spontaneous thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in collagen induced thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in epinephrine induced thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in adenosine diphosphate induced thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in fibrinogen level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in fibrinogen degradation products level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in D-dimer level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in serum endothelin1 level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups.
Measure: Difference in serum nitric oxide level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Secondary Outcomes
Description: For SNPs that will occur associated with occupational COPD differences in hsCRP and TNFα serum concentration between subjects with different genotypes will be established separately for exposed to dust COPD group and for exposed to chemicals COPD group.
Measure: Relationship between genotype and phenotype characteristics, such as an inflammation activity, assessed by hsCRP and TNF α serum concentration, in different occupational COPD groups. Time: 1 day (a single measurement)2 Molecular, Cytological Features and Genetic Susceptibility of Occupational Chronic Obstructive Pulmonary Disease Attributable to Different Environmental Exposures 2.
The objective of this study is to investigate molecular, cytological and genetic features of occupational chronic obstructive pulmonary disease (COPD) in conditions of different occupational exposures. In order to achieve this goal serum pro-inflammatory cytokines and standard inflammation markers level, hemostasis, cytological analysis of bronchoalveolar lavage fluid and association of single nucleotide polymorphisms (SNPs) rs1800470 transforming growing factor β1 (TGF β1) gene, rs1828591 hedgehog interacting protein (HHIP) gene, rs4129267 interleukin 6 receptor (IL-6R) gene, rs1051730 nicotinic acetylcholine receptor 3 (CHRNA3) gene with COPD in subjects exposed to silica dust and in those exposed to polycyclic aromatic hydrocarbons exhaust will be investigated. The relationship between genotype and phenotype characteristics, such as an inflammation activity, assessed by C-reactive protein (hsCRP) and tumor necrosis factor alpha (TNF α) serum concentration, in different occupational COPD groups will be studied. The hypothesis is that the mechanisms underlying disease development and progression are different due to environmental risk factor that reflex in differs in disease attributes - molecular biomarkers, cytology results and genetic susceptibility between COPD due to dust, COPD due to chemicals and COPD in smokers therefore COPD can be subdivided into ecological phenotypes according to environmental risk factor.
NCT02284295 Chronic Obstructive Pulmonary Disease Other: exposure to respirable silica dust Other: exposure to aromatic hydrocarbons MeSH: Lung Diseases Lung Diseases, Obstructive Pulmonary Disease, Chronic Obstructive Genetic Predisposition to Disease
HPO: Abnormal lung morphology Chronic obstructive pulmonary disease Obstructive lung disease
In order to achieve this goal serum pro-inflammatory cytokines and standard inflammation markers level, hemostasis, cytological analysis of bronchoalveolar lavage fluid and association of single nucleotide polymorphisms (SNPs) rs1800470 transforming growing factor β1 (TGF β1) gene, rs1828591 hedgehog interacting protein (HHIP) gene, rs4129267 interleukin 6 receptor (IL-6R) gene, rs1051730 nicotinic acetylcholine receptor 3 (CHRNA3) gene with COPD in subjects exposed to silica dust and in those exposed to polycyclic aromatic hydrocarbons exhaust will be investigated.
Association of SNPs rs1800470 TGF β1 gene, rs1828591 HHIP gene, rs4129267 IL-6R gene, rs1051730 CHRNA3 gene with COPD in subjects exposed to dust and in those exposed to chemicals.
Primary Outcomes
Description: Comparison of groups
Measure: Difference in serum interleukin 1 beta (IL-1β) level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in serum tumor necrosis factor alpha (TNFα) level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in spontaneous thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in collagen induced thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in epinephrine induced thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in adenosine diphosphate induced thrombocyte aggregation between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in fibrinogen level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in fibrinogen degradation products level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in D-dimer level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in serum endothelin1 level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Difference in serum nitric oxide level between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Comparison of groups
Measure: Differences in cytological analysis of bronchoalveolar lavage fluid results between COPD patients exposed to dust, chemicals and tobacco smoke Time: 1 day (a single measurement)Description: Odds ratio and 95% confidence interval will be calculated for each occupational group. Controls - healthy people.
Measure: Association of SNPs rs1800470 TGF β1 gene, rs1828591 HHIP gene, rs4129267 IL-6R gene, rs1051730 CHRNA3 gene with COPD in subjects exposed to dust and in those exposed to chemicals. (Odds ratio and 95% confidence interval) Time: 1 day (a single measurement)Secondary Outcomes
Description: For SNPs that will occur associated with occupational COPD differences in hsCRP and TNFα serum concentration between subjects with different genotypes will be established separately for exposed to dust COPD group and for exposed to chemicals COPD group.
Measure: Relationship between genotype and phenotype characteristics, such as an inflammation activity, assessed by hsCRP and TNF α serum concentration, in different occupational COPD groups. Time: 1 day (a single measurement)