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Report for SNP rs2234237r25r

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Association Between TREM-1 Gene Polymorphisms and Prognosis in Sepsis Patient

Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. Blocking of TREM-1 can protect against sepsis in mice. This study was designed to investigate whether TREM-1 genomic variations were associated with the prognosis of sepsis. We sequenced 30 sepsis patients with TREM-1 gene of four exons by PCR sequencing. When analyzing the results of sequencing, we found two gene polymorphisms located in exon-2 and exon-4, respectively. Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246. Two common polymorphisms (rs2234237,rs2234246) within the TREM-1 gene were detected in 80 patients with severe sepsis and in 80 healthy control subjects. This study was explored that whether or not polymorphisms detected within the TREM-1 gene may play a major role in the predisposition to prognosis of sepsis in a Chinese Han cohort.

NCT01490424 Sepsis
MeSH: Sepsis
HPO: Sepsis

Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246.

Primary Outcomes

Description: The survival time of patients more than 28days is defined as survival. The survival time of patients less than 28days is defined as death

Measure: Patients Outcome

Time: 28 days


HPO Nodes


Sepsis
Genes 74
ECE1 TGM1 NRTN BLNK CYBB ATP7A IKZF1 AK2 ALOXE3 CYBA FERMT3 RAG1 NCF1 LIG4 EDN3 CXCR4 PGM3 CD79B COG4 PIK3R1 CHD7 SEMA3C SERAC1 TFRC CYP4F22 SAMD9 FOXP3 WIPF1 MNX1 RET HYOU1 HLA-B MYLK BTK IGHM PLEC DCLRE1C LRRC8A RAG1 RAG2 IL7R ABCA12 CTNNB1 EDNRB IL2RG IL2RG NIPAL4 NCF4 IGLL1 LIPN MYH11 AK2 ITGB4 ADA LMOD1 ELANE SULT2B1 TCF3 CD79A IL7R ALOX12B SEMA3D GALT APC GDNF MMUT SDR9C7 NCF2 RMRP WAS ACTG2 CYBC1 NFKB2 G6PC3