SNPMiner Trials by Shray Alag


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Report for SNP rs1885988

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Web-based Weight Loss Intervention

Excess weight is a major risk factor underlying leading causes of death globally, including cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the same lifestyle intervention arms in prior weight loss randomized controlled trials, large inter-individual differences in weight loss success have been observed, ranging from >50lbs of weight loss to >10lbs of weight gain. Both genetic and non-genetic factors underlying differential adherence and weight loss success are poorly understood.

NCT03400696 Overweight and Obesity Behavioral: Lower carbohydrate diet Behavioral: Higher fiber diet Behavioral: Physical activity focused
MeSH: Overweight Weight Loss
HPO: Decreased body weight Weight loss

Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more weight on lifestyle interventions; and b.) to test the performance of a randomized controlled trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence.

Primary Outcomes

Measure: Change in weight from week 1 to week 12 of intervention

Time: 12 weeks

Secondary Outcomes

Measure: Change in waist circumference from week 1 to week 12 of intervention

Time: 12 weeks

Measure: Change in waist-to-hip ratio from week 1 to week 12 of intervention

Time: 12 weeks


HPO Nodes


Weight loss
Genes 318
COL5A2 GPC3 MPL COL12A1 BCL10 BIRC3 CCR1 AK2 DNAJC13 SNCA ABCC8 LMNA ERCC4 RBBP8 JAK2 PALLD BRCA2 ND4 RFWD3 RNF168 TYMP HMBS HYMAI PTEN LIPA TYMP HLA-B SLC25A11 SUCLA2 SNCA ATRIP BMPR1A FAN1 TRNQ MPL IRF2BP2 HMGCL CYP24A1 WT1 PML ERCC4 FANCI GCK KDSR GJB4 LRRK2 MECP2 TSHR TET2 RARA HTT MAD2L2 ERCC3 CENPE IFNGR1 NOD2 COL6A2 FANCF SDHA TRAIP HLA-DQB1 NOD2 POLG MDH2 GPR35 FANCA CEP152 HLA-DPA1 IL12B SLX4 CHEK2 SLC11A1 SDHB ERCC5 TRIM37 TRIM28 COL6A3 CDH23 MAFB PANK2 BRCA2 HLA-B TRNF POU6F2 TBL1XR1 FIP1L1 SEMA3C BCL2 JAK2 NDP PALB2 JPH3 BCOR HLA-DPB1 ZFP57 HLCS TP53 FANCE IL10 KCNJ18 SDHD FANCM COL5A1 MAX DIS3L2 BMPR1A TP53 ACAT1 IL12A-AS1 THPO KRT10 IL12A NABP1 MC2R CALR IL23R MST1 FH FANCG PCNT MLH3 CCND1 JPH3 TMEM127 ND6 SLC39A4 NUMA1 WT1 SDHC SDHA ACADM ND5 AVP DLST SEMA3D TP53 TRPV4 TSHR FLI1 EIF2AK3 PMS1 SDHB CDKN2A STAT3 PRNP NBN POLG ECE1 DCTN1 REST CACNA1S SDHAF1 ATP7B KCNJ11 NRTN IGH F5 STAT3 PTPN22 TXNRD2 TRIP13 AKT1 FOXP1 JAK2 MLH1 TRNH HLA-DRB1 PMS2 SDHAF2 PDX1 INS LRP12 NNT SLC9A6 RRM2B FOXP3 DCTN1 ERAP1 TP53 SLC52A3 TRNL1 STAT6 PRNP GATA4 MSH6 RET KIF1B ERCC4 FANCB KRAS RAD51 IGH VHL FANCD2 VPS13A KRAS TRNS2 MSH2 BCL6 SDHC GATA2 EDNRB ATM PRKAR1A BRCA1 RHBDF2 PIK3CA KRT1 TRNS1 GBA CACNA1S INSR GJB3 SDHD CTLA4 NPM1 IL6 RPS20 BRCA1 XRCC2 KCNJ18 GALT H19 MPL HAVCR2 TRIM28 BRCA2 GDNF FAS COL1A1 WT1 HLA-DRB1 TLR4 PTPN22 HSPG2 COX1 STAT4 IKZF1 CNTNAP1 ATRX ABCC8 STAR DAXX MRAP CCND1 TET2 POLG EWSR1 CDC73 GJA1 EDN3 ND1 CENPJ NAB2 IGH LPIN2 FANCL SLC52A2 HLA-DRB1 TRNW HLA-DRB1 COX3 GIGYF2 SDHD PIK3R1 B2M EPCAM TCF4 PLAGL1 TGFB1 PRNP KLRC4 PLK4 KIF1B TGFBR2 SEMA4A SCNN1B UBAC2 BTK HLA-B COX2 CFTR SDHB ATR TTR GNPTAB PLA2G6 C4A RET SMAD4 SCNN1A ERCC2 UNC80 BTNL2 FANCC PTEN MALT1 SCNN1G PALB2 BRIP1 RB1 EIF4G1 MEFV GABRA3 CUL4B PTEN ZBTB16 KCNJ11 VPS35 COL6A1 PRTN3 RAD51C UBE2T RRM2B STAT5B SLC6A8 JAK2 MLX