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Report for SNP rs4883264

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Association Between cd163 Gene Polymorphisms and Sepsis Among Chinese Han Population

CD163 is a member of the scavenger receptor cysteine-rich family (SRCR) is exclusively expressed on cells of the monocyte lineage.CD163 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. This study was designed to investigate whether CD163 genomic variations were associated with the prognosis of sepsis. We sequenced 30 sepsis patients with CD163 gene of seventeen exons by PCR sequencing. When analyzing the results of sequencing, we found five gene polymorphisms located in exon-2,exon-5 and exon-11, respectively. Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs3210140, two polymorphisms located in exon-5 are synonymous variations rs4883264 and rs4883263, the last two located in exon-11 are synonymous variations rs61729512 and rs150018775 . Five common polymorphisms (rs2234237,rs2234246) within the CD163 gene were detected in 200 patients with severe sepsis and in 200 healthy control subjects. This study was explored that whether or not polymorphisms detected within the CD163 gene may play a major role in the predisposition to prognosis of sepsis in a Chinese Han cohort.

NCT01504243 Sepsis
MeSH: Sepsis Toxemia
HPO: Sepsis

Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs3210140, two polymorphisms located in exon-5 are synonymous variations rs4883264 and rs4883263, the last two located in exon-11 are synonymous variations rs61729512 and rs150018775 .



HPO Nodes


Sepsis
Genes 74
ECE1 TGM1 NRTN BLNK CYBB ATP7A IKZF1 AK2 ALOXE3 CYBA FERMT3 RAG1 NCF1 LIG4 EDN3 CXCR4 PGM3 CD79B COG4 PIK3R1 CHD7 SEMA3C SERAC1 TFRC CYP4F22 SAMD9 FOXP3 WIPF1 MNX1 RET HYOU1 HLA-B MYLK BTK IGHM PLEC DCLRE1C LRRC8A RAG1 RAG2 IL7R ABCA12 CTNNB1 EDNRB IL2RG IL2RG NIPAL4 NCF4 IGLL1 LIPN MYH11 AK2 ITGB4 ADA LMOD1 ELANE SULT2B1 TCF3 CD79A IL7R ALOX12B SEMA3D GALT APC GDNF MMUT SDR9C7 NCF2 RMRP WAS ACTG2 CYBC1 NFKB2 G6PC3