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Report for SNP rs1906591

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Detection of Occult Paroxysmal Atrial Fibrillation in Cryptogenic Stroke Patients or TIA Using an Implantable Loop Recorder and Correlation With Genetic Markers.

Atrial fibrillation (AF) is the significant risk factor of ischemic stroke with incidence about 20% of all ischemic strokes. The undiagnosed AF in cryptogenic stroke patients could be present but not revealed by rutinne ECG.

NCT02216370 Cryptogenic Stroke or TIA Atrial Fibrillation
MeSH: Stroke Atrial Fibrillation
HPO: Atrial fibrillation Paroxysmal atrial fibrillation Stroke

Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261.

Primary Outcomes

Description: Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 chromosome 4q25, polymorphism rs1906591,rs10033464 and ZFHX3 chromosome 16q22, polymorphism rs2106261

Measure: Documented Atrial Fibrillation after episode of cryptogenic stroke / TIA Documented genetic mutation PITX2 and ZFHX3

Time: 12 months

Secondary Outcomes

Measure: Time to documented Atrial Fibrillation Reccurent stroke or TIA Stroke Secondary Prevention Therapy changes within 12 months Neuroimaging Changes ( brain CT/ MRI)

Time: 12 months

Other Outcomes

Measure: Follow-up of patients with implanted ECG monitor REVEAL XT incidence of atrial fibrillation, stroke or TIA

Time: 3 Years


HPO Nodes


Stroke
Genes 165
NAGS GDF2 MPL VHL GTF2I CST3 FBN1 SON BAZ1B SLC2A10 MAT2A PRKAG2 TREX1 ND1 SNAP29 TRNH COL4A1 TRNS2 ACAD9 TRNS1 CRELD1 ACVRL1 DPM3 GUCY1A1 CPS1 ND4 GNAQ LMNA RFC2 FOXE3 APP SMAD4 TGFBR2 TPP2 COL4A1 TRNK TRNL1 PRNP GATA4 HBB MYH11 COX2 HTRA1 SLC19A2 ENG TGFB3 PCNT CCM2 PIGA MMUT TRNQ TRNQ MPL MPL GTF2IRD1 SMAD4 TRNS2 ND6 PMM2 MYH11 SMAD4 GYS1 PRKCH ANGPTL6 SCN5A XYLT2 HSD11B2 ACTG1 TRNS1 CBS LIMK1 APP MFAP5 GUCY1A1 DYRK1B MTHFR TRNV SH2B3 COX3 MYH11 ALOX5AP NOS3 ENG NR2F2 TRNL1 ADA2 COX1 SLC19A2 MYD88 GLA JAG1 MLXIPL TP53 TRNW CLIP2 TRNC KRAS TRNF TET2 NOTCH3 ADA2 ND1 NR3C1 GATA6 NPPA ELN RFT1 SMARCAL1 AGXT FLNA TRNW COX3 JAK2 CYP11B1 CYTB F2 SMAD3 APP ACTA2 TNXB OTC APP COL3A1 TET2 ZMPSTE24 PRKG1 MYLK ASS1 TBL2 COX2 WFS1 THPO ELN PIK3C2A CALR JAK2 ENG TGFBR3 TGFB2 ND5 TTR F5 ND6 MECP2 ELN GLA ACTB ACVRL1 COX1 MYBPC3 APP TREX1 ND5 CST3 KCNQ1 COL3A1 ABCC6 ZAP70 TRNF HTRA1 LOX XYLT1 STIM1 JAK2 TGFBR1
Paroxysmal atrial fibrillation
Genes 12
KCNJ5 SCN5A CSRP3 KCNA5 KCNJ2 SCN2B MYL4 ABCC9 TBX5 KCNE2 SCN1B PRKAG2