SNPMiner Trials by Shray Alag

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Report for SNP rs3853445

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials

1 A Pilot and Feasibility Study to Determine if a Common Atrial Fibrillation Risk Locus Modulates Differential Response to Antiarrhythmic Drugs

In this pilot and feasibility study, the investigators will enroll patients with frequent symptomatic episodes of atrial fibrillation (AF) in a cross-over study testing two different classes of anti arrhythmic drugs (AADs). This pilot and feasibility study will provide preliminary data for a larger study in which the investigators will test the hypothesis that a common AF genetic risk allele modulates response to different AADs.

NCT02347111 Atrial Fibrillation Drug: Flecainide Drug: Sotalol
MeSH: Atrial Fibrillation
HPO: Atrial fibrillation Paroxysmal atrial fibrillation

Blood processing, DNA extraction, and genotyping: Blood samples will be drawn into ethylenediamenetetraacetic acid (EDTA) tubes and immediately refrigerated at 4° C. Plasma will be separated by centrifugation and stored at -80° C. DNA will be extracted from the buffy coat using a commercially available kit (Qiagen Puregene, Valencia, California) and stored at -20° C. Study participants will be genotyped for three common chr4q25 SNPs (rs2200733, rs17570669, and rs3853445) using Sanger sequencing.

Then we will create a second model that replaces the separate chr4q25 SNP terms for a combined chr4q25 risk score calculated by adding the beta-coefficients for the genotypes at rs2200733, rs17570669, and rs3853445 found in the first model.

Primary Outcomes

Measure: AF burden (Percent of time subject is in atrial fibrillation)

Time: 3 months

HPO Nodes

Paroxysmal atrial fibrillation
Genes 12