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Report for SNP rs8111699

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Pharmacogenetics of Metformin Action in PCOS

1. The polycystic ovary syndrome is the major cause of infertility in the United States. Metformin has been shown to increase frequency of ovulations in PCOS, and is used in clinical practice to treat infertility, but some women with PCOS do not respond to metformin treatment. 2. Knowing that a specific gene predicts the effect of metformin on ovulation would facilitate more efficient and effective treatment of infertility in PCOS.

NCT00703508 Polycystic Ovary Syndrome Drug: Metformin 500 mg tablet
MeSH: Polycystic Ovary Syndrome
HPO: Polycystic ovaries

Number of Responders/Non-responders for Each STK11 rs8111699 Genotype (C/G, C/C, G/G).

We hypothesize that women with the polycystic ovary syndrome (PCOS) who have the G/G genotype of single nucleotide polymorphism (SNP)_ rs8111699 in STK11 will exhibit a significantly greater response to metformin, in terms of ovulation, compared with women with either the C/G or C/C genotype.

Primary Outcomes

Description: Responders were defined as those that had a doubling of baseline ovulation rate estimated by self-report of menstrual history.

Measure: Number of Responders/Non-responders for Each STK11 rs8111699 Genotype (C/G, C/C, G/G)

Time: 9 months

Description: Ovulations were determined by measurement of daily urine pregnanediol-3-glucuronide or weekly progesterone levels over 6-9 months of study duration for each participant. The ovulation rate was calculated as the number of confirmed ovulation events per months of study participation.

Measure: Ovulation Rate Over Study Duration for STK11 Genotypes CC, CG and GG

Time: 9 months

Secondary Outcomes

Description: Bivariate fit (RSquare with P values) of ovulation rate post treatment by change in total testosterone and Matsuda Index for each of the 3 genotypes (G/G, C/G, C/C)

Measure: Determine in Which Genotype(s) Frequency of Ovulation Correlates With Improvement in Reduction in Total Testosterone and Insulin Sensitivity as Measured by the Matsuda Index.

Time: 9 months


HPO Nodes


Polycystic ovaries
Genes 81
SRY LIPE CYB5A NR0B1 INSR GTF2I ATM DMRT1 AKT1 BAZ1B HNF1A CLIP2 BSCL2 SRY LMNB2 SDHC MAP3K1 HSD3B2 CORIN LMNA AGPAT2 NR0B1 MMP2 ELN CBX2 FSHR FOS NR5A1 STOX1 RFC2 CAVIN1 ANTXR2 CYP11B1 CIDEC CYP17A1 STK11 PLIN1 GNAS SOX3 MMP14 KLLN CAV1 SDHD WT1 SEC23B PTEN PIK3CA POR TBL2 LMNA NR5A1 GTF2IRD1 SOX9 SOX9 LMNA PPARG ESR1 PTEN AGPAT2 MSX1 SOX9 AKT2 NR5A1 CYP17A1 LMNA BSCL2 ALMS1 PPARG LMNA FLT1 SDHB SRY LIMK1 POR PTEN PRKAR1A PPARG DHH SETD2 CYP19A1 AKT1