SNPMiner Trials by Shray Alag


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Report for SNP rs2279238

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 The Role of Two Nuclear Receptors for Oxysterols as a Molecular Cause of Uterine Dystocia: LXR Alpha and LXR Beta

Despite the fact that a link between cholesterol and the myometrium has been clearly established, no study investigating aspects of cholesterol metabolism and uterine dystocia currently exists. This study is a pilot study whose aim is to test the hypothesis that an association between uterine dystocia and single-nucleotide polymorphisms (SNPs) in the genes coding for the LXRs.

NCT01107158 Uterine Inertia Dystocia Biological: Whole blood sampling
MeSH: Dystocia Uterine Inertia

The polymorphisms of interest are the following SNPs: rs3758673, rs3758674, rs12221497, rs11039155, rs2279238, rs7120118, rs35463555, rs1052533, rs2248949, rs41432149, rs1405655, rs4802703.. Inclusion Criteria: - Patients undergoing C-section for a dystocia: 2 to 3 hours of stagnation in labor progress are observed (ie no increasing dilation, and uterine contractions less that 3-5 per 10 minutes) in spite of measures taken to overcome dystocia (oxytocin injection and artificial breaking of waters) - the child is alive - the child does not have apriori known malformations that could interfere with a vaginal birth - foetus in cephalic position - full term pregnancy (>= 37 weeks of amenorrhea) - single birth - patient has signed consent - patient is affiliated with a social security system Exclusion Criteria: - vaginal birth - programmed C-section - C-section is chosen because the fetus has a cardia rhythm problem, and there is no stagnation in the labor process - multiple pregnancy - the child is in a breech position - premature birth (<37 weeks amenorrhea) - in utero fetal death - fetal malformation known before birth that could interfere with a vaginal birth - non french-speaking patient (impossible to correctly inform the patient) - patient under guardianship Inclusion Criteria: - Patients undergoing C-section for a dystocia: 2 to 3 hours of stagnation in labor progress are observed (ie no increasing dilation, and uterine contractions less that 3-5 per 10 minutes) in spite of measures taken to overcome dystocia (oxytocin injection and artificial breaking of waters) - the child is alive - the child does not have apriori known malformations that could interfere with a vaginal birth - foetus in cephalic position - full term pregnancy (>= 37 weeks of amenorrhea) - single birth - patient has signed consent - patient is affiliated with a social security system Exclusion Criteria: - vaginal birth - programmed C-section - C-section is chosen because the fetus has a cardia rhythm problem, and there is no stagnation in the labor process - multiple pregnancy - the child is in a breech position - premature birth (<37 weeks amenorrhea) - in utero fetal death - fetal malformation known before birth that could interfere with a vaginal birth - non french-speaking patient (impossible to correctly inform the patient) - patient under guardianship Uterine Inertia Dystocia Dystocia Uterine Inertia null

Primary Outcomes

Description: The polymorphisms of interest are the following SNPs: rs3758673, rs3758674, rs12221497, rs11039155, rs2279238, rs7120118, rs35463555, rs1052533, rs2248949, rs41432149, rs1405655, rs4802703.

Measure: The multi-loci genotype of the target DNA sequence.

Time: Day 1


HPO Nodes