SNPMiner Trials by Shray Alag


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Report for SNP rs1799724

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

There is one clinical trial.

Clinical Trials


1 Subclinical Atherosclerosis: Biomarkers of Early Disease

Subclinical atherosclerosis is the atherosclerotic process identified before clinical symptoms and thus it can be a useful marker of future cardiovascular events. It can be evaluated by many methods. This study included the diagnosis of subclincal atherosclerosis by four different methods: coronary calcium score, carotid doppler ultrasound to quantify intima media thickness and carotid plaques, exercise stress test and ankle brachial index. Clinical data, anthropometric measures (body mass index, abdominal circumference), markers of inflammation (high sensitive - C reactive protein, TNF alfa and Lipoprotein Associated Phospholipase A2), fat tissue function (leptin, resistin and adiponectin), glucose metabolism (fasting plasma glucose, glycated hemoglobin and insulin) and genetics markers of atherosclerotic process were evaluated as biomarkers of subclinical atherosclerosis in a uneventful population.

NCT02487615 Primary Prevention
MeSH: Atherosclerosis
HPO: Atherosclerosis Type IV atherosclerotic lesion

Genotyping of DNA at the following rs2383206, rs10757274, rs10757278, rs1051931, rs16874954 and rs1799724 and RNA of PLA2G7 (2-ΔCT), TNF-α (2-ΔCT), LEP (2-ΔCT), LEPR (2-ΔCT).

Blood sample was also stored for DNA (rs2383206, rs10757274, rs10757278, rs1051931, rs16874954 and rs1799724) and RNA PLA2G7 (2-ΔCT), TNF-α (2-ΔCT), LEP (2-ΔCT), LEPR (2-ΔCT) extraction and analyses.

Primary Outcomes

Description: Subclinical atherosclerosis evaluation by quantifying intima media thickness by Doppler

Measure: Carotid intima-media thickness (cIMT)

Time: Four Weeks

Secondary Outcomes

Description: Subclinical atherosclerosis evaluation by Coronary Artery Calcium by CT

Measure: Coronary artery calcium score

Time: Four weeks

Description: Subclinical atherosclerosis evaluation by brachial ankle index (BAI) by blood pressure measurement

Measure: Brachial Ankle Index

Time: Four weeks

Description: Myocardial ischemia investigation by treadmill exercise test

Measure: Ischemia induced by exercise stress test

Time: Four weeks

Description: Blood samples for Adiponectin, resistin, leptin, tumor necrosis factor alpha (TNF-α), lipoprotein associated phospholipase A2 (Lp-PLA2) dosing

Measure: Adiponectin, resistin, leptin, tumor necrosis factor alpha (TNF-α), lipoprotein associated phospholipase A2 (Lp-PLA2)

Time: Four weeks

Description: DNA and extraction from leukocytes

Measure: Genotyping of DNA at the following rs2383206, rs10757274, rs10757278, rs1051931, rs16874954 and rs1799724 and RNA of PLA2G7 (2-ΔCT), TNF-α (2-ΔCT), LEP (2-ΔCT), LEPR (2-ΔCT)

Time: Four weeks


HPO Nodes


Atherosclerosis
Genes 88
SMPD1 LDLRAP1 LDLR ACTA2 CYP7A1 ANTXR1 GLB1 FBN1 APOE APOB MAT2A ABCG8 ZNF687 LMNA AGPAT2 NPC1 LMNA GGCX FOS GGCX AGXT LMNA FOXE3 CAVIN1 SERPIND1 SMAD4 TGFBR2 SMPD1 APOB SMAD3 MYH11 CAV1 LMNA ACTA2 ABCG8 TNXB CYP27A1 COL3A1 ZMPSTE24 TGFB3 PRKG1 MYLK CEP19 LMNA ALMS1 LDLRAP1 CSF2RA APOA5 NOTCH3 ESR1 LCAT ABCA1 KCNJ5 MYH11 CSF2RB ENG TGFBR3 TGFB2 SC5D ABCC6 WRN ENPP1 HGD ANGPTL6 ELN XYLT2 LMNA ABCA1 BSCL2 LIPC PPARG SMPD1 LMNA LCAT MFAP5 ABCA1 BANF1 LMNA LOX MYH11 ABCC6 PPARG LOX XYLT1 PCSK9 NPC2 TGFBR1 ABCG5