This study is part of a series of studies that will explore how the mind and the brain work to cause episodes of uncontrollable shaking in people who have no known underlying brain or medical disorder. The study is conducted at NIH and at the Brown University Rhode Island Hospital. Healthy volunteers and people with functional movement disorders (FMD) or non-epileptic seizures (NES) who are 18 years of age or older may be eligible for this study. Patients with NES have 3 teaspoons of blood drawn. The blood is tested for two genes that are normally found in healthy individuals to see if they are found more frequently in patients with uncontrolled shaking. Patients with FMD have blood drawn for testing and also undergo functional magnetic resonance imaging (fMRI) to look at how the brain functions while the subject performs a specific task. MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues. During the scan, the subject lies on a table that can slide in and out of the scanner, a metal cylinder. The scan lasts about 60 to 90 minutes, during which the subject may be asked to lie still for up to 10 minutes at a time and to perform tasks, such as identifying the gender of faces shown on a screen. Healthy volunteers may have blood drawn for genetic testing or fMRI or both.
Description: fMRI BOLD signal change focusing on regions of interest during fear learning taskMeasure: fMRI BOLD signal change focusing on regions of interest during fear learning task Time: throughout protocol
Description: fMRI BOLD signal change focusing on regions of interest during emotional valence taskMeasure: fMRI BOLD signal change focusing on regions of interestduring emotional valence task Time: throughout protocol
Description: Structural grey matter brain data (VBM)Measure: Structural grey matter brain data (VBM) Time: throughout protocol
Description: Percent BOLD signal change during interoceptive attention relative to exteroception control condition in dorsal mid-insulaMeasure: Percent BOLD signal change during interoceptive attention relative to exteroception control condition in dorsal mid-insula Time: throughout protocol
There is one SNP
Exploratory objectives are to investigate in CD patients: - The frequency of several gene polymorphisms that are implicated in stress and affective disorder, including 5HTTLPR S/S (serotonin receptor), COMT (catechol-o-methyltransferase enzyme), Val/Met BDNF (brain-derived neurotrophic factor) and FKBP5 rs1360780 genotypes, as well as other polymorphisms or mutations to be determined later.