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Report for Clinical Trial NCT01936480

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Genetics of QT Response to Moxifloxacin

The purpose of this study is to assess the ability of common genetic variants in aggregate to predict drug-induced QT prolongation in healthy subjects using moxifloxacin.

NCT01936480 Cardiac Arrhythmias
MeSH: Arrhythmias, Cardiac
HPO: Arrhythmia

2 Interventions

Name: Moxifloxacin 400mg once time

Type: Drug

Moxifloxacin group

Name: Placebo

Type: Drug

Placebo Group


Primary Outcomes

Description: We will measure the QT interval on ECG up to 6 hours after administration of moxifloxacin or placebo

Measure: QT interval duration

Time: 6 Hours

Purpose: Prevention

Allocation: Randomized

Crossover Assignment


There is one SNP

SNPs


1 rs12143842

For example, SNP rs12143842 is a C/T SNP; for each copy of the T allele the QT interval is 3.50 msec higher such that individuals with the TT genotype have a QT interval 7 msec higher than those with CC genotype and individuals with the CT genotype have a QT interval 3.5 msec higher.



HPO Nodes


HPO:
Arrhythmia
Genes 585
SCN4B ANK2 RPL18 COX3 ATP6 SCN5A ABCG8 ATP6 ND1 TNNT2 GPD1L TNNI3 ND5 AGPAT2 TRNS1 CACNA2D1 CRELD1 MTFMT EYA4 TET2 HMBS SLC40A1 TMEM43 ND2 SCNN1B TAB2 SLC25A11 COX2 TMEM43 EMD TRNQ HMGCL MYL3 LAMA2 ECE1 MTO1 TRPM4 KCNE1 ENPP1 HTRA2 RRAS2 SCN5A FGFR3 SCN5A MYH6 SLC2A10 CPT2 RPL15 COX3 GYG1 SCNN1G LARS2 ADA2 MECP2 RPS7 SCN5A MYH7 TRNL1 PLN TRPM4 CAV3 MYPN SLC19A2 GBA TMEM43 MEN1 TOP3A CDH23 CLIP2 MYPN BMP2 TRNF KCNE1 NDUFS2 LMNA PEX5 HCN4 SDHC NPPA EP300 CTNNA3 FHL1 SGO1 EFEMP2 GPX4 KCND3 CYTB MFAP5 RYR2 PCCB HLA-DPB1 DMD KCNE3 TLL1 MEFV TNXB CACNA2D1 MYLK2 KCNJ18 TRDN LZTR1 CASQ2 ACTN2 TBL2 CPOX ALG10B RYR1 TGFB3 PPOX ND5 COX1 NKX2-5 SCN1B ND4L FH RPL31 CACNB2 CIZ1 TMEM127 MYH7 TBX5 RPS26 PEX13 SDHA NEXN PEX12 RPS27 COX1 JUP ISCU LMNA ND5 KCNJ2 SMAD3 SCN4A SLC25A20 DES GPC3 BVES LDLRAP1 GTF2I RPL11 BMP2 RYR2 TWNK LMNA DNMT3A TRNH GNAQ FOXC2 NDUFB11 PEX6 KCNH2 KCNQ1 CASR FOS LMNA PEX1 SCN2B PAX8 TRNK TRNL1 PCCA SDHB NAA10 POLG CAV1 KCNQ1 CPT1A TBX3 VHL ND1 DTNA SCN5A CALM3 USP18 TRNE PEX10 KCNH2 ACAD9 HMBS CSF2RB KCNQ1 DSC2 ND1 TAZ COQ9 ACADVL EMD TRNS1 KCNE2 TDP2 CACNA1S SCN5A CACNA1C SDHD GATA1 PRDM16 ACTC1 SCN5A FOXC2 KCNJ18 PCSK9 FBLN5 SDHB RAF1 KCNQ1 DPP6 GPC4 PSMB8 CPT2 TRNL1 PTPN22 HSPG2 LDLR PTPN11 COX1 VHL GDAP1 RPL5 TRNC TECRL SOS2 CLIC2 KCNJ5 DSP ACTC1 TRPM4 GATA6 SCN10A JUP RRAS CAV3 HCN4 SDHD TRNW COX3 PLN EFEMP2 MRAS TTPA GNAI2 TSHR GYG1 TRDN KYNU SCN1B AKAP9 RPL35 GJA1 DSP KIF1B COX2 TTR RET RRM2B TAB2 RPS19 KCNJ5 PHYH DST SNTA1 BTNL2 DES GTPBP3 SCN3B SCN9A ND5 SOX10 HADHA GDNF NDUFB11 GABRA3 GLA AKAP9 KAT6B KCNA5 CALM1 PTEN SNTA1 SYNE2 MGME1 VHL CREBBP CLCNKB SCN2B PRTN3 CAV3 TPM3 PPARG GATA5 DNAJC19 RIT1 BMP2 ND6 ND4 ERCC6 RPL35A HJV APOB BAZ1B PEX7 CALM1 TNNI3 KRAS RASA2 SYNE2 HNF1A LMNA KCNJ8 KCNQ1 TMEM70 SOS1 ND4 MYOZ2 MYH7 LMNA RFC2 KCNE5 COL4A1 WIPF1 GATA4 PHOX2B HADHB RAF1 HLA-B CPT1A SLC19A2 GSN FBP1 PEX6 XK TWNK TRNQ SDHD GJA5 SLC25A20 GTF2IRD1 CRLF1 ND6 CACNA1S ABCA12 SCN3B FLNC PTPN11 RET GPD1L BSCL2 MRPS14 SPECC1L CASQ2 IFNG DMPK TRNV KCND3 LAMP2 NPPA RET KCNJ2 MDH2 NAA10 FMO3 RPL26 TRNK HFE NUP155 ABCC8 NR2F2 CALM2 HLA-DPA1 KCNE1 CACNA1C GLA TPM1 GNB5 ATP6 RBM20 LMNA TRNW TSC1 COQ4 FBXL4 GNB5 CLCF1 SCNN1A LDB3 TTN CPOX KCNE2 RPS10 ELN CAV3 TGFBR2 TTN CAVIN1 MAX TSC1 LRP6 CYTB ABCC9 HCN4 SLC25A4 HCCS SDHD MAX RAF1 FHL1 CSF2RA BRAF TCAP ND6 PKP2 TSPYL1 SRY PSMB8 PEX5 AKAP10 HCCS TSPYL1 PEX26 ND4L ELN ND6 ELP1 SCN4B PKP2 KYNU CSRP3 CACNA1C ACADL HLA-B PIK3CA ACADM KCNQ1 DLST TP53 TRNF CAVIN1 PEX3 SDHB BRAF DMD BRAT1 CYTB ABCG5 CACNA1S RPS15A TSC2 TRDN SALL4 ACADVL PTPN22 AKT1 GAA GNA11 PRKAG2 RYR1 DSG2 TNNI3K TRNS2 MYH7 SDHAF2 TECRL POLG2 KCNE2 TSC2 LMNA ANK2 UCP2 RPS29 TNNC1 CALM2 PRKAG2 RAF1 GPX4 SCN5A A2ML1 NOS1AP NKX2-5 TMEM70 LMNA CALM1 KCNJ2 PEX2 CALM2 PRKAG2 KCNE3 GJA1 ND4 TRNS2 SYNE1 SDHC TBX3 TRDN SLMAP GJA5 FHL1 LIPT1 LIMK1 PEX11B CLIC2 GATAD1 KCNH2 CTLA4 BANF1 SCN5A TRPM4 SCN10A KCNK3 CACNA1S RPL27 SLC12A3 POLG2 CASQ2 KCNH2 WAS JPH2 PGM1 COX7B SCN1B PPA2 RYR2 HLA-DRB1 CACNA1D CALM2 COX3 IKZF1 RPS24 ATRX KCNQ1 HFE SCN5A DAXX SLC12A3 ND1 GLUL HNF4A TAB2 KCNQ1 KCNJ2 JUP TPM2 MGME1 PEX14 TANGO2 TMEM127 PEX1 TGFBR1 ELP1 FLAD1 CACNB2 PEX16 ZMPSTE24 RANGRF ABCC9 COX7B HRAS ND2 MYL2 HBB ABCC6 PEX19 TSR2 WIPI2 SCN1B KCNJ11 NRAS LMNA NDUFB11 RPS17 MYL4 ERCC8 KIF1B SCN9A MYBPC3 CNBP CALM1 CPT2 RPS28 FBP1 DSP KCNE1 NKX2-5 ABCC9 SMAD3