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Report for Clinical Trial NCT03968445

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Neuroinflammation After Myocardial Infarction - Imaging Substudy

The purpose of the study is to see if positron emission tomography and magnetic resonance imaging (PET/MRI) with an investigational drug called [18F]DPA-714 will show inflammation in the brain after a heart attack. This study may help physicians and researchers better understand the role of brain inflammation in heart disease and develop new treatments to protect the brain.

NCT03968445 Myocardial Infarction
MeSH: Myocardial Infarction Infarction
HPO: Myocardial infarction

1 Interventions

Name: [18F]DPA-714-PET/MRI

Description: [18F]DPA-714-PET/MRI

Type: Drug

Recent Myocardial Infarction undergoing elective percutaneous coronary intervention


Primary Outcomes

Description: The regional brain concentrations of [F-18]DPA-714, a PET imaging marker of neuroinflammation, will be compared between study participants who have recently been hospitalized for acute myocardial infarction (AMI) and a control group undergoing elective percutaneous coronary interventions (PCI).

Measure: TPSO-PET measurement of neuroinflammation after acute myocardial infarction

Time: 2 years

Purpose: Diagnostic

Allocation: Non-Randomized

Single Group Assignment


There is one SNP

SNPs


1 rs6971

English speaking with at least 8th grade education 4. High or mixed affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971.

Diagnosis of dementia 12. Low affinity binder for TSPO ligands based on genotyping for SNP rs6971.



HPO Nodes


HPO:
Myocardial infarction
Genes 79
IL12B TLR4 LDLRAP1 LDLR GTF2I GLA APOB STAT4 CCR1 BAZ1B IKZF1 TP53 SH2B3 CLIP2 ABCG8 CYP27A1 MYH9 CTNNB1 HLA-B AGPAT2 ELN FOS RFC2 ENPP1 CAVIN1 ERAP1 MEF2A MYH9 BCHE CAV1 MEFV LRP6 LMNA HLA-B LPL THOC2 CYP27A1 KLRC4 TET2 IL10 SCNN1B UBAC2 CEP19 HLA-B PIGA TBL2 CFTR RAF1 MPL BRAF C4A GTF2IRD1 IL12A-AS1 CALR IL12A IL23R JAK2 SCNN1A ABCA1 WRN JAK2 SCNN1G HGD PTPN11 MEFV BSCL2 CBS LIMK1 ABCA1 DYRK1B BRAF SLC2A10 SH2B3 PPARG PCSK9 FAS ABCG5 MLX ABCC6