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Report for Clinical Trial NCT03211507

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Idiopathic Pulmonary Fibrosis Job Exposures Study

A case-control study to investigate whether job exposures are an under-recognized cause of idiopathic pulmonary fibrosis (IPF) using an interview to collect information about previous jobs and a blood test to investigate genetic susceptibility.

NCT03211507 IPF Idiopathic Pulmonary Fibrosis
MeSH: Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis Fibrosis
HPO: Pulmonary fibrosis

2 Interventions

Name: Computer-assisted telephone interview

Description: Occupational history

Type: Other

Case Controls

Name: Genetic analysis

Description: To include analysis of known susceptibility markers

Type: Genetic

Case Controls


Primary Outcomes

Description: estimated using logistic regression for any vs no asbestos exposure and adjusting for age and smoking status

Measure: Association between asbestos exposure and IPF

Time: 2 years

Secondary Outcomes

Description: estimated using logistic regression for categories of cumulative exposure and adjusting for age and smoking status

Measure: Dose-response relationship between asbestos exposure and IPF

Time: 2 years

Description: MUC5B rs35705950 and asbestos exposure odds ratio.

Measure: Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.

Time: 2 years

Time Perspective: Prospective

Case-Control


There is one SNP

SNPs


1 rs35705950

Gene-environment interaction (for MUC5B rs35705950 and asbestos exposure) odds ratio.. MUC5B rs35705950 and asbestos exposure odds ratio..



HPO Nodes


HPO:
Pulmonary fibrosis
Genes 80
HLA-DPA1 RCBTB1 PSMC3IP HLA-DRB1 PTPN22 CASP10 POLR3H TERT HLA-DRB1 SP110 HPS4 CLCA4 CCN2 ASAH1 FAM111B TINF2 SFTPA1 MUC5B ATP11A ABCA3 TERT RNF168 KIAA0319L TERT TERT MUC5B RASGRP1 PLEC HLA-DPB1 NUP107 NOP10 NKX2-1 CCR6 THOC2 PRKCD NHP2 DPP9 STX1A RTEL1 TERC HLA-DRB1 DSP FAS DKC1 DCTN4 NR5A1 PARN FAM13A FAS CCR6 TGFB1 CAV1 AP3B1 TERC SFTPC IRF5 BTNL2 CAV1 ALMS1 TERT HPS1 SFTPA2 STN1 SPIDR FASLG CTLA4 RTEL1 SFTPC SFTPA2 BMP15 PARN PRTN3 MRPS22 TINF2 CFTR RNF168 IRF5 FSHR CCN2 TERC