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Report for Clinical Trial NCT03262363

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Interaction of Polymorphism rs35652124 With Curcumin Supplementation on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function in Patients With Early Diabetic Nephropathy

The increase in the prevalence of diabetes mellitus (DM) is one of the greatest public health challenges worldwide. Epidemiological studies have shown that DM is the leading cause of chronic kidney disease (CKD) in patients initiating renal replacement therapy. In our country, diabetes accounts for about 60% of all incidents of dialysis. On the other hand, CKD is currently considered a noxious disease because patients not only have the likelihood of progression to end-stage renal disease (ESRD), but because these renal alterations are associated with an increased risk of cardiovascular complications and premature death for the same cause. Most studies have focused on traditional risk factors (poor diet, physical inactivity and obesity) for the development and progression of renal damage, and less information exists on non-traditional factors such as oxidative stress and mainly, the low antioxidant response that characterizes both DM and nephropathy. In addition, there is a great variation in the susceptibility to and progression of kidney disease between different populations that is not explained by the presence of traditional factors and that could be triggered by genetic variations and its interaction with other components related to the environment and lifestyle. Fortunately, there is sufficient scientific evidence that early detection and modification of negative lifestyle factors can not only delay or halt the progression of the renal function decline to ESRD but can also significantly reduce the incidence of cardiovascular disease leading to premature death in most of these patients. Therefore, it is suggested that this risk may be determined by the interaction of lifestyle factors with the presence of susceptibility alleles, which may vary from one population to another. It is now known that hyperglycemia causes a state of oxidative stress and inflammation that can be counteracted by diet supplementation with some natural antioxidants such as curcumin. It has been shown that this molecule has multiple pharmacological properties: antioxidant, anti-inflammatory, cardioprotective, renoprotective, among others. In clinical trials a positive effect of curcumin has been seen in the treatment of diabetes and its complications. This has generated a relative optimism in the search for new curcumin treatment targets where oxidative stress is of great relevance, as is the case with CKD. However, there are still doubts about its efficacy as an adjuvant in the prevention of CKD. Additionally, the role played by interindividual variability in genes involved in the mechanism of action of curcumin is still incipient, more studies in this knowledge area are necessary.

NCT03262363 Chronic Kidney Diseases Diabetes Mellitus, Type 2 Polymorphism
MeSH: Kidney Diseases Renal Insufficiency, Chronic Diabetic Nephropa Diabetic Nephropathies Diabetes Mellitus, Type 2
HPO: Abnormality of the kidney Chronic kidney disease Nephropathy Type II diabetes mellitus

2 Interventions

Name: Curcumin/NFE2L2 A>G

Description: The administration will be orally and the patient will be instructed to take two capsules per day for one week, one in the morning 15 minutes before breakfast and another at night 15 minutes before dinner, accompanied by a cup of 240 mL of pure water. It will be indicated to continue with their usual medical treatment.

Type: Combination Product

Curcumin/NFE2L2 A Curcumin/NFE2L2 A> Curcumin/NFE2L2 A>G

Name: Placebo/NFE2L2 A>G

Description: The administration will be orally and the patient will be instructed to take two capsules for 24 weeks, one in the morning 15 minutes before breakfast and another in the evening 15 minutes before dinner, accompanied by a 240 mL cup of pure water. They will be advised to continue their usual medical treatment.

Type: Combination Product

Placebo/NFE2L2 A Placebo/NFE2L2 A> Placebo/NFE2L2 A>G


Primary Outcomes

Description: mRNA and active protein NRF2

Measure: Change from Baseline expression Gen NFE2L2 at 3 months

Time: Baseline at 3 months

Description: mRNA and active protein NRF2

Measure: Change from Baseline expression Gen NFE2L2 at 6 months

Time: Baseline at 6 months

Description: Superoxide dismutase, hemoxygenase 1, Glutathion peroxidase using the ELISA technique

Measure: Change from Antioxidant capacity at 3 months

Time: Baseline at 3 months

Description: Superoxide dismutase, hemoxygenase 1, Glutathion peroxidase using the ELISA technique

Measure: Change from Antioxidant capacity at 6 months

Time: Baseline at 6 months

Description: Glomerular Filtration Rate (Serum creatinine) and Albuminuria (Albumin/Creatinine Ratio)

Measure: Change from Renal Function at 3 months

Time: Baseline at 3 months

Description: Glomerular Filtration Rate (Serum creatinine) and Albuminuria (Albumin/Creatinine Ratio)

Measure: Change from Renal Function at 6 months

Time: Baseline at 6 months

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs35652124

Interaction of Polymorphism rs35652124 With Curcumin Supplementation on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function in Patients With Early Diabetic Nephropathy.

Curcumin on NFE2L2 Gene Expression, Antioxidant Capacity and Renal Function According to rs35652124 in Diabetic Nephropathy The increase in the prevalence of diabetes mellitus (DM) is one of the greatest public health challenges worldwide.

Inclusion Criteria: - With T2DM according to the American Diabetes Association - With any time of T2DM evolution - With CKD stage 1-3a according to the K/DIGO guidelines Exclusion Criteria: - Incomplete evaluations - That they have not been attached to the assigned intervention with an established frequency of <80% - Decide to withdraw from the study Inclusion Criteria: - With T2DM according to the American Diabetes Association - With any time of T2DM evolution - With CKD stage 1-3a according to the K/DIGO guidelines Exclusion Criteria: - Incomplete evaluations - That they have not been attached to the assigned intervention with an established frequency of <80% - Decide to withdraw from the study Chronic Kidney Diseases Diabetes Mellitus, Type 2 Polymorphism Kidney Diseases Renal Insufficiency, Chronic Diabetic Nephropa Diabetic Nephropathies Diabetes Mellitus, Type 2 Aim: To evaluate the interaction between rs35652124 polymorphism and curcumin supplementation on the levels of NFE2L2 gene expression, antioxidant capacity and renal function in patients with early diabetic nephropathy (EDN).

Once they have signed the written consent they will be cited for the first blood sample collecting (5 mL) to be used for genomic DNA extraction and genotyping for the rs35652124 polymorphism.



HPO Nodes


HPO:
Abnormality of the kidney
Genes 1660
GPC3 UBR1 FAT4 GLI3 IL17RA SOX9 STRA6 CASP10 PIGL PLCE1 SDCCAG8 KRT17 GLI1 SDHD COL4A4 LRP4 NDUFB10 LMNA FAT4 FGF8 WAS TXNL4A ROR2 CTU2 REN ENPP1 PLG LRP5 HSD11B2 GBA RAB23 AXIN2 DYNC2LI1 WDR19 SPRY2 ASXL1 PNPLA6 PIGV TBX1 NPHP4 TMEM67 CFH BLK MYO1E ZFPM2 SPINK5 HIRA GBE1 ALG9 WDR60 CFHR5 MCTP2 BUB1B LHX1 BCOR HLA-DPB1 KAT6B PET100 MEFV SF3B4 SSR4 IL10 PYCR2 CDK6 WDR73 SLC36A2 YAP1 PIK3C2A B3GLCT FCGR2A COG6 B9D2 IGF2 OGG1 ITGB4 HPRT1 IFT27 NUP205 COQ8B CWC27 RNU4ATAC LDLRAP1 GTF2I CCNQ SLC25A22 RPGRIP1L ZNF687 COA8 FAM20C RPS26 ACVRL1 VPS33B COPB2 GABBR2 RECQL4 CYP4F22 DLL1 ITGA2B ND4 CCR6 ND2 DCHS1 C1R BBS7 KLLN OCRL SIX3 PEX6 TRNE CD81 CHD7 CRB2 BRCA1 WDR35 ETFB MARS1 FLNB DVL1 LETM1 MAP2K2 HRAS WT1 NDUFB8 NEK8 GREB1L KCTD1 CEP41 ARID1B LRIG2 SERPINF2 GATA3 CC2D2A SDHB GPC4 XDH LDLR AR SAA1 MET ALG9 CLDN10 DUSP6 PACS1 SDHD EFEMP2 SMARCC2 AGGF1 MAP2K1 PIGA ESCO2 ITGA3 HNF1A CFI ALG1 RAD51C DNAJB11 DGKE MINPP1 APOA1 TTR KIF14 AFF4 FLNA ZAP70 WDR34 GLA MYH11 NDUFAF1 DYNC2LI1 KCNJ11 HYLS1 VHL ATP6 TTC21B RAD51C DDX59 RMRP FGA COL5A2 VAMP7 NDUFB3 APOB CCR1 SON PDE6D GP1BA KCNQ1OT1 STRA6 FANCD2 GAS1 KMT2D FAM20A ATRX RFC2 FAM20A WIPF1 TRNT CLDN19 PTH1R SLC37A4 TBC1D20 SRY TRNQ PTPN22 TRNN IL17F MEFV FIBP SCARB2 FANCI RPGRIP1L GP9 UMPS MKKS NSD2 MAP3K1 BSCL2 VANGL1 MAD2L2 PTPN22 SEMA3A SLC3A1 TMEM216 SCN2A OFD1 SMARCAL1 WDR4 UMOD GPR35 FGF10 FANCA COL4A4 HLA-DPA1 CD96 SLX4 STIL CEP290 TAPT1 CEP55 SIX5 MKS1 SCNN1A CEP83 FLNA BBS2 OSGEP PLVAP KMT2D LAMB2 PPP2R3C SMC1A TSC1 MICOS13 HNF1B TP53 FUT8 WT1 ZNF592 RFWD3 TMEM67 NPHP1 HLA-DRB1 BRAF BUB1 LPIN1 ELN TACR3 LRIG2 ITGB3 EMP2 PDSS2 NDUFV1 FREM2 SMOC1 LIPN PLD1 SLC2A2 FGFR3 ACSL4 PTPN11 SHANK3 KANSL1 ALPL SDHB PALB2 MYMK HNF1A KAT6A UMOD GPKOW SLC30A9 TREX1 WDR4 SNAP29 CCDC141 WASHC5 ND3 NPHP3 INS HPSE2 TSC2 NDUFS7 BUB1 CENPF SHH ERAP1 CEP290 COPA PEX12 EYA1 ANLN ZIC2 PLG SOX10 BRAF DLC1 ITGB3 FCGR2B ALMS1 NLRP3 ITGA8 PDX1 GANAB KDM6A NARS2 PQBP1 BBIP1 EVC CTLA4 AVPR2 TRNS1 H19 H19 BRCA2 AIRE NDUFS3 SDCCAG8 AKT1 CCND1 PBX1 HLA-DRB1 PGAP3 GPC4 ACP5 ARX CDC73 MAGI2 PEX16 ND1 IFT27 AHI1 OCRL RAB3GAP1 BBS1 TMEM127 TCF4 ARID2 NPHP1 PEX2 PIK3CA FRAS1 PIK3CA RAB3GAP2 CASR ETFDH WDR19 SF3B4 APPL1 FLII ACTN4 C1QA C4A FKRP AGPAT2 IQCB1 USP9X FANCC COLEC11 NIPAL4 WRN MEFV PKHD1 ZNF423 NTNG1 KIF1B TRNT1 PEX13 MMUT UBE2T DACT1 PEX1 DZIP1L ND5 SBDS ADGRG2 ABCG8 B2M RAI1 GATA4 LAGE3 NLRP3 BRCA2 ANOS1 IQSEC2 PKD1 SLC6A19 CYB561 WT1 CASR NUBPL MYLK TCTN3 TMEM216 TMEM231 STXBP1 NPHP4 CC2D2A IRF2BP2 KCNA1 KEAP1 SEC63 WT1 KYNU ERCC4 KCNJ5 OCRL FLNA VIPAS39 SOX4 PAX6 GLI3 CDKL5 SCNN1G SCNN1B FOXF1 INPP5E YAP1 RPGRIP1L POU6F2 CAMKMT NDUFA11 SIX5 SLC4A4 H19-ICR PORCN SLC7A7 TRIM28 CDKL5 GP1BA SI PUF60 GLIS2 GDF6 FIP1L1 NDUFS2 PIGW BMPER TMEM107 MAP3K7 COL5A1 TMEM216 AMMECR1 TBC1D24 COX20 IFT43 COG7 FANCI FAH SEC24C IL2RG CCND1 NUMA1 H19 NRAS FLI1 FGFR1 CA2 PAFAH1B1 CACNA1D NAA10 MKKS SOX11 REST TDGF1 HMGA2 GALNT3 PEX14 CORIN FANCA PRDM16 FOS BBS10 ARL3 GEMIN4 NDUFAF3 PIEZO2 TRIP11 HBB CAV1 STS FANCB RARB TBX15 MMUT ANTXR1 POLR3A BCOR SMAD4 UMOD LCAT EDNRB NOTCH2 SEMA3E ADAMTS13 PRKCSH AMMECR1 FASTKD2 SIX1 NDUFA6 SPP1 ALG8 GCM2 RPGRIP1 ATP7B CEP63 PEX1 KCNE5 ALDOB TRIM28 RPGRIP1L SNAI2 CCN2 FGFR2 TMEM231 GRHPR CPT2 FKTN LEMD3 PTPN22 COX1 COL14A1 ZEB2 WT1 CFTR KCNQ1OT1 C4A COQ7 TMEM237 CLDN19 FANCC EVC2 NDUFB9 LPIN2 RREB1 PDSS2 STK11 HESX1 PLAGL1 APC MYT1 CCDC22 GRHPR SCO1 SLC4A1 GDF3 RET PIGY TRIM32 PRKCD GSN PHYH COX10 TMEM126B DYNC2H1 FLT1 ADA BUB1B KNL1 CPLANE1 IFT43 CDC73 CLCNKB TREX1 PRTN3 COL3A1 FXYD2 FLNA BMPER MBTPS2 APC APC2 MME FOXI1 DYNC2H1 BBS9 WNT5A NDUFA1 NSD1 PEX7 NPHP4 TRNW RPL11 FLNB ND6 ABCC8 WDR35 FANCB TRNV ND4 INF2 GNAS WASHC5 SLC49A4 NDUFAF3 COL4A1 APRT ITPR3 ETFA ARHGDIA TACO1 SEC61A1 HNF1B CLCN5 TBX1 NEUROD1 ACTG2 NADK2 MSH3 GTF2IRD1 RAI1 SALL4 PML CACNA1S IFT140 GATA3 C1QBP NBN MAPKBP1 SPECC1L ADCY10 BMP4 PLCD1 SETD5 HPRT1 TMEM237 F10 MLH1 MUC1 AMER1 KIAA0753 TP53RK MAP3K7 NDUFAF4 HMGA2 HS6ST1 KDM6A CLCN5 FBXL4 ROR2 USP8 PGAP2 WNT4 KANK2 GLIS3 WDR34 CAVIN1 BNC2 GBA CFI SIX1 ZFP57 KCNJ11 FANCE FANCM MAX CASR RNF139 RAF1 NCAPD3 MAGED2 ZNF423 FLNA CFI HNF1B PGM3 AAGAB IL12A CYP11B2 ELP1 VHL FLCN SLC37A4 DZIP1L PIGN NCAPG2 SLC22A12 FH CLCNKB LRP5 CRTAP RBM10 NDUFB11 NDUFAF3 FAT4 IFT172 LRP2 DYNC2H1 TFAP2A INF2 STAT3 PTPN22 TRIP13 AKT1 ALOXE3 SGPL1 DHDDS SDHC TTC37 CTNS WDR35 GP1BB C1QB PDX1 EXT2 NUP107 SPART RRM2B OCLN ENPP1 FANCE COL4A3 PEX5 KCNJ10 PIGL RTTN MYO5B CYP27A1 BAP1 PAX2 PYGM WDR19 SETBP1 DCLRE1C RNU4ATAC FBN1 IL7R CEP290 PIGO COL4A5 PIK3CA NOD2 ADCY10 TMEM260 POR SLC2A9 MITF DYNC2LI1 NSD1 SLC35A2 TRNL1 WDR19 ITGB4 WAS SHH SMC1A NUP133 PGK1 NDUFS8 RET STAT4 GRIA3 IKZF1 HIC1 MYH9 KCNJ10 CACNA1D PCK2 RAD21 PEX19 HABP2 KLHL7 H19 CDC42 UBR1 HNF4A SCO2 ATP1A1 CPLANE1 ROBO2 TRAF3IP1 CDH23 WT1 NR0B1 ELP1 HSPA9 SLC3A1 POR KCTD1 DKC1 NUP133 ND3 IRAK1 GRIP1 MMUT ABCC6 MEFV UQCC2 SON KCNAB2 PTPRJ POLE ATRX B9D2 HOXA13 RBM8A PHF21A ATRX ARID1B CLPB HNF1B WDR34 RIPK4 TP63 HPSE2 NUP160 TRIM37 MBTPS2 STX3 AGPAT2 PORCN COQ2 FRAS1 LZTFL1 FH TGIF1 HMBS PHGDH C8ORF37 SALL1 WDPCP SCNN1B SLC25A11 PRKCD BBS4 COQ2 PIGA TMEM67 YY1AP1 NR5A1 CYP24A1 DICER1 CA2 IFT172 PMM2 NPHP3 GCK TTC21B DSTYK HGD PAH WDR73 GNAO1 ACTG1 NDUFAF5 SALL4 MKS1 NDUFV2 ALOX12B LAMB2 PREPL PAX2 WFS1 PPM1B INSL3 TRNL1 CEP290 HOXD13 COX8A EYA1 ALDH18A1 WDR19 WT1 WNT4 KAT6B PUF60 TCTN2 TRNF TBL1XR1 CLCN5 EP300 COX14 LIPT2 GLI2 ARX SLC1A1 DCC STRADA WT1 SLC6A20 PEX5 PTEN LEMD3 SNRPB C1QC BRCA2 GREB1L NOTCH3 CDKN1C ARVCF MST1 CFH TMEM237 B9D1 AQP2 PIGV TMEM127 SDHA IGF2 SULT2B1 CHST14 JMJD1C TFE3 PGAM2 ND5 FGF17 APC HSD17B4 NF1 CEP55 SDR9C7 TMEM138 SUFU ZIC3 SLITRK6 VDR TTC37 SHPK KIAA0586 TP53RK SMARCA4 NFIA BUB1B PEX2 BCS1L AIP HNF4A MOCS1 BCS1L MNX1 SDHB MEN1 XPNPEP3 CRB2 ERCC4 RMND1 LAGE3 VHL HNF1A FANCD2 NODAL XRCC4 ND1 NPHP1 CCNQ FGFR3 CHD4 PKHD1 ZIC3 KIF14 ITGA2B CTLA4 POMT2 PEX11B SDHD KRAS RAI1 ITGA8 INVS NPM1 SLX4 USP8 DVL3 CCDC141 NPHS1 DDX59 ACTG2 COL1A1 CHRM3 MDM2 IL6 HSPG2 FGFR1 BBS10 ABCC8 RERE MSH6 CCBE1 WDR60 PGM3 CEP135 MKKS BBS5 FANCL CLCNKA COX3 FOXF1 RBM10 IGF2 NUP93 SLC12A1 MASP1 POMT1 CDC73 PHEX INVS HLA-B MAFB COX2 ARX SOX9 DNAJC21 FAS BBS12 FREM2 OSTM1 IFT140 BTNL2 GPC3 SLC34A3 DNA2 TRIM8 PEX3 GDNF ACTB PTEN ZBTB16 GPC4 DICER1 PIK3CA ABCC6 PPARG KITLG SLC9A3R1 BCOR STAT5B NLRP3 SF3B4 COQ6 G6PC3 CSPP1 COL7A1 PHYH NPHP1 EPG5 SETD2 REN LIG4 MKKS POU3F4 STOX1 RFWD3 HYMAI NRIP1 HLA-B RAP1A CDK4 CPT2 GSN PCK1 ATN1 ALX4 FGFR3 SIK1 CEP164 SLC25A20 PIGL STAT4 ABCA12 XYLT2 CCBE1 FLNA AP2S1 PEX3 CFH RET PIGY LZTFL1 STAT1 KISS1R CASP10 RAD21 TRIP13 MYD88 GLA B3GLCT NOTCH2 FAN1 GLMN BSND RAP1B CC2D2A CLDN16 TMCO1 TNXB FGF20 THOC6 ENPP1 GCK ELN SMARCAL1 DNASE1L3 MCM5 FLCN MAX PALB2 MKS1 PKD2 CD46 DIS3L2 MITF TBCK RPL26 LMX1B PTPRO HDAC8 SPRY4 HOGA1 IL23R PIK3CA JAM3 ANOS1 NOTCH2 ND6 COG1 KYNU PROKR2 ADA ATP7A LMNA DLST ZAP70 UFD1 F2 EIF2AK3 STAT3 CC2D2A TMEM67 TGM1 APOE APOE WDPCP GNA11 RYR1 LMNB2 KCNJ10 SERPINH1 SDHAF2 RBM8A SOX9 CASK OFD1 APC PEX13 ESCO2 EHMT1 SASS6 TMEM231 TTC8 DMP1 CD2AP GCM2 TMEM70 TRRAP EYA1 KCNH1 TPRKB FAS DCDC2 TP63 TCTN2 SDHC APOL1 VPS33A LDHA DCC G6PC PRKAR1A THBD CISD2 TTC8 DCHS1 CHRM3 B9D1 AVPR2 RPS19 LRP4 NEK8 TFAP2A ARMC5 SLC12A3 FGFR2 TCTN3 PIK3R2 KMT2A CEL TP53 ARL6 MAP11 PAX1 TMEM216 TRIP13 AKT1 TMEM126B DPH1 SMARCB1 VAC14 TTC21B C8ORF37 TNXB SCARB2 PC DIS3L2 HNF4A NPHS2 NPHP3 WT1 COL4A3 TRNK WDR19 ADAMTSL1 PNKP UBAC2 AKT3 IL17RD RAG2 CTNNB1 NPHP1 CFTR CTNS ASPM AGT SARS2 RECQL4 ERCC8 MMACHC EBP PRKCSH CSPP1 FLCN STXBP1 TBC1D24 TMEM67 NIPBL CDON LYZ CDKN1C RASGRP1 FLRT3 CEP290 CENPJ BICC1 NSDHL DHCR7 TMEM231 NUP85 CTNNB1 CLCNKB WNT4 RPGRIP1L PEX19 ALG8 FGFR3 SOX10 FN1 DISP1 COX6B1 LMOD1 TPRKB TBC1D8B NOD2 CTH MFSD2A FANCF TBX18 ND2 KLF11 TAF13 SURF1 OPLAH IFIH1 WNT4 CILK1 MLXIPL BRAF CLIP2 DHCR24 POU6F2 SERPINA1 FLCN LARGE1 SH2B1 AGXT CDK5RAP2 CEP290 SHANK3 REST PGK1 NDUFS2 SDCCAG8 PRSS1 MSH2 SRP54 IFT172 TBL2 ALMS1 DNASE1 PLEC DMRT3 KRAS SLC17A5 NPHP3 CSPP1 IL12A-AS1 NABP1 TSC1 FH FANCG MEOX1 TCN2 DSTYK SFTPC PDE6D SLC29A3 B4GAT1 COMT CD151 SLC26A1 CLEC7A MCPH1 SKI WWOX HPRT1 GPC3 SRCAP WDR62 SLC7A7 IFT122 TBX22 APRT CLCN5 SPECC1L FLCN TRNH PEX10 ARID1A PIEZO2 PHC1 NUP107 CASR GP1BB CHN1 MAFB TRNL1 SOX17 BBS1 CPT1A KMT2A RAD51 FREM1 NDUFS1 GABRD FREM1 GP1BB SKIV2L WDR11 OSGEP MRPS22 DIS3L2 KIAA0753 NDUFS4 TRPC6 CD96 SC5D SDCCAG8 FANCB PAX4 SLC26A4 VHL NSMF NEK1 TRNS1 NPHP1 CAD OFD1 XRCC2 FOXC2 PEX10 FIG4 PCSK9 FBLN5 INTU GNA11 ANKS6 NIPBL WT1 COL4A1 IFT80 KCNJ1 HAAO VHL NDUFS6 HPRT1 HNRNPU ATP6V0A4 LMX1B CIT CDC73 TRNW PRCC YWHAE CDKN1B KYNU C1QA GDF6 TIMMDC1 TSC2 KLRC4 KIF1B DICER1 FOXRED1 ADAMTS3 PLG USP9X GLI3 RBBP8 WT1 POGZ WNT3 RSPO2 IFT80 CEP290 FANCB TMEM216 SMARCE1 FASLG PAX2 CREBBP SLC7A9 NDUFAF2 CTRC LTBP4 XYLT1 SPINK1 C3 PRDX1 WDR73 ERCC6 FGFR1 ANTXR1 TMEM67 DPF2 BAZ1B EHMT1 COA8 BSCL2 SLC34A1 INS KIF7 PROK2 NUP133 ABCC8 SMS NXN RERE IQCB1 DACT1 DLL4 ATRX CPT1A FGFR2 AQP2 IL17RC PIGQ ATP6V1B1 TMEM107 SMC3 FN1 CC2D2A CFB PTPN11 ARNT2 CPT2 ITGA2 RARA EP300 HELLPAR PMM2 PEX7 GNB1 MECP2 FOXG1 C3 IFNG MDH2 PIGP PRODH TRNK IRF5 ENG CTNS TALDO1 NPHP3 SLC4A1 ALDOB JAG1 DEAF1 NEUROD2 MAFB TSC1 EIF2AK3 H19 IGF2 OFD1 KCNQ1 ACE LMX1B GNB1 TRIM32 ANKLE2 PTCH1 PEX26 BUB3 COL25A1 AMMECR1 NAA10 SLC34A1 TRAF3IP2 TCTN3 WFS1 TRAF3IP1 LIG4 CEP120 ZNF148 SRY FEZF1 PREPL DNASE1L3 FAM149B1 FLNA HMOX1 SETBP1 MOCOS CEP164 FOXH1 MBTPS2 RAB18 HNF4A PIGN H19 HOGA1 CCND2 BBS12 TMEM138 ABCG5 CFHR1 GDF2 TSC2 KCNJ11 SOX18 NUP107 DHODH FUZ RAG1 TREX1 ERBB3 LMNA LMNB2 PEX1 SRC ARL6 PIGT FOXP3 ITGA6 PPP1R15B HDAC4 INPP5E SLC5A2 CHD7 PDGFRB ARL6IP6 CEP120 NSUN2 TRNS2 TMEM67 MED25 SLC34A1 TBX3 NELFA NPHS1 CAV1 HPS1 FOXE1 LIMK1 FGFR2 CCDC28B CFHR3 BBIP1 SC5D PTCH1 FAS PEX12 DHCR7 AGXT TMEM231 ND1 TLR4 PIGN PROKR2 SLC12A3 CD109 NRAS TBX1 CDKN1B CHD7 AGTR1 FGF8 SNRPB WNT3 FGFR2 MGME1 KLLN SLC3A1 PEX6 PPP3CA KIF14 SEC23B GPC3 CD46 ADA2 HRAS SEMA3E PRPS1 SALL1 CHD7 BRIP1 FANCL BBS4 COL4A3 SDHB CEP152 CIT CEP57 TBX1 PLCD1 CPT2 LEMD3 PIK3R2 MOCS2 IARS1 ABCC6
Chronic kidney disease
Genes 119
SOX18 SLC7A7 IFT122 TMEM67 UMOD NPHP4 SGPL1 TMEM67 NUP160 CTNS CORIN NPHP3 NUP133 NUP107 LZTFL1 LAGE3 NUP107 STOX1 INF2 PLCE1 SDCCAG8 IQCB1 COL4A3 WT1 APRT ARHGDIA XPNPEP3 SEC61A1 GSN HNF1B ANLN PAX2 NUP85 WDR19 TMEM231 CLCN5 NPHP4 OCRL DCDC2 OSGEP KYNU TRPC6 NPHP1 CEP290 IFT172 COL4A5 FN1 NOD2 APOL1 REN GATA3 MAPKBP1 NEK8 TPRKB WDR19 TBC1D8B INVS SPRY2 LAMB2 PAX2 NPHP4 CTNS MUC1 COL4A4 CFH TP53RK MYO1E ALDOB CEP290 JAG1 FAN1 WT1 SAA1 CFHR5 CLCN5 TMEM126B GLIS2 MAGI2 CEP83 CLDN16 CLDN19 TTC21B CLCN5 AHI1 SH2B1 AGXT CEP290 BNC2 LAMB2 NUP93 TRAF3IP1 NPHS2 NPHP3 COL4A3 PKD2 INVS NPHP1 WDR19 TMEM67 NPHP1 RAD51C DNAJB11 DGKE WDR19 ACTN4 TRAF3IP1 IFT140 IQCB1 MMUT DSTYK DZIP1L SARS2 FLT1 NUP205 CEP164 COQ8B IFT43 TTC21B CD151
Nephropathy
Genes 104
HPRT1 COL7A1 WDR73 TMEM67 HNF1A NUP107 TP53RK RPGRIP1L AGPAT2 INS B2M ABCC8 VPS33B NLRP3 FOS FAM20A MAFB LYZ COL4A1 WIPF1 KCNJ10 WT1 SCNN1B CEP290 CAV1 CLDN19 INPP5E SEC61A1 LAGE3 NEUROD1 TPRKB RPGRIP1L UMOD SCARB2 CC2D2A NOD2 WAS TTC21B VIPAS39 IFT140 PAX4 SLC26A4 CISD2 BSCL2 PDX1 PAX6 DYNC2LI1 SCNN1G PRODH WFS1 KLF11 WDR4 WDR19 WAS TMEM231 BLK CEL HIC1 SAA1 MAFB MYH9 SCNN1A WDR60 TMEM237 GCK OSGEP WDR34 CAVIN1 LMX1B YWHAE HNF4A WT1 MEFV KCNJ11 IFT172 ALG1 TMEM216 WDR19 ADA2 APPL1 ZNF423 APOA1 TTR CEP120 NUP133 IFT140 WT1 NPHP1 TMEM237 IFT80 CCND1 DYNC2H1 GLA TREX1 MMACHC PPARG CD151 EIF2AK3 PAFAH1B1 FGA TMEM138 PRDX1 CC2D2A FOXI1
Type II diabetes mellitus
Genes 182
SNRPN USH2A PDE6A IDH3A LIPC SNORD116-1 GTF2I GCGR C8ORF37 BAZ1B PCARE TRNH RP1 PRPF6 LMNA IPW IFT88 PDE6B ZNF408 ABCC8 RGR TTC8 PROM1 PDX1 AR ND4 NPAP1 HGSNAT NEK2 RFC2 CA4 KLF11 SEMA4A BEST1 TRNL1 RHO IDH3B MKRN3 SCAPER PPARG PCNT PEX10 TUB XRCC4 SNRNP200 SLC2A2 CEP19 CRB1 ABCA4 EYS MAPK8IP1 TRNQ TCF7L2 POLR3A RP9 GTF2IRD1 TRNE FBN1 PRPF4 AKT2 ZNF513 ARL6 TRNS2 RDH12 CRX STUB1 ARL3 NEUROD1 KLHL7 RBP3 SPINK1 NR2E3 ALMS1 TRNS1 KCNJ11 LIMK1 INSR HNF1A ARL2BP BRAF RPE65 AHR PWRN1 GLRX5 PRPF31 MAK PNPLA6 PRCD RLBP1 HNF1B AHI1 IMPDH1 TRNK AGBL5 TRNL1 TULP1 DHX38 GPD2 HMGA1 ATM NDN COX1 FAM161A NRL DHDDS CDHR1 MAGEL2 MKRN3-AS1 CLIP2 CTNNB1 AIP TRNF SLC12A3 IFT140 SLC30A8 RP2 POLA1 ND1 REEP6 IMPG2 ELN PWAR1 LIG4 RETN BLM PDX1 CNGA1 TRNW COX3 IRS1 INSR ROM1 BBS2 PRPF3 GCK KIZ TBL2 COX2 WFS1 GCK PRPH2 LRAT ABCC8 SNORD115-1 PRPF8 SPATA7 ENPP1 GUCA1B MEN1 IRS2 MERTK POMGNT1 HNF4A WRN ND6 HNF1A PTPN1 PPP1R3A CERKL CLRN1 PAX4 SLC7A14 KIAA1549 MC4R IGF2BP2 PDE6G ARHGEF18 SAG MOG AMACR TOPORS MTNR1B CLCNKB ND5 PLCD1 OFD1 FSCN2 IFT172 HERC2 CYP19A1 RPGR CNGB1