Despite large efforts trying to improve diagnostic and therapy of sepsis have been made over the last decade (e.g. initiation of the Surviving Sepsis Campaign, defining evidence based sepsis therapy bundles) the mortality of septic shock remains high and causes high socioeconomical burden of disease. The purpose of this pilot study is to evaluate the design and conduct of a projected full scale clinical trial.
Description: Circadian regulation by expression of clock genesMeasure: Assessment of circadian regulation Time: These parameters are measured during intensive care unit stay, for a maximum of 3 days
Description: Quality of life is measured by SF-36 questionnaireMeasure: Quality of life Time: Up to 3 and 6 months
Description: Cognitive function is measured by Repeatable Battery for the Assessment of Neuropsychological StatusMeasure: Cognitive function Time: Up to 3 and 6 months
Description: Ncounter neuroinflammation and micro rna panel are analysedMeasure: Multiplex-Genexpression analysis Time: These parameters are measured during intensive care unit stay, for a maximum of 3 days
Description: Nagalase Enzyme activity is expressed in nmol/min per Milliliter. Analysis is evaluated with the perioperative Nagalase results of 10 patients in the clinical trial Phydelio (EudraCT-No 2008-007237-47).Measure: Nagalase enzyme activity Time: This parameter is measured at the beginning of the investigation
Description: Venous return will be assessed after ICU admission by venous return pressure gradient (dVR)Measure: Venous return Time: This parameter is measured at the beginning of the investigation
There is one SNP
Furthermore, polymorphisms such as rs7221412, a common polymorphism near period homolog 1 (PER1), was associated with the timing of activity rhythms and also showed a suggestive time-dependent relationship with both cerebral cortex and monocytes PER1 expression and an association with time of death (Lim ASP et al., 2012).