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Report for Clinical Trial NCT01664962

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Search for Genetic Basis of Vulvodynia

The purpose of this study is to investigate the possibility of an association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).

NCT01664962 Vulvodynia
MeSH: Vulvodynia


Primary Outcomes

Description: the possibility of an association between Localized Provoked Vulvodynia (LPV) that is both severe and primary and polymorphic markers/single nucleotide polymorphisms (SNPs) in and around the genes encoding heparanase (HSPE-1), Vanilloid Receptor VR1 (TRPV1), and Nerve Growth Factor (NGF).

Measure: Genetic association of Vulvodynia

Time: four years

Time Perspective: Cross-Sectional

Case Control


There are 8 SNPs

SNPs


1 rs11099592

Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow: 1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population 2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.


2 rs11102930

3. NGF gene: A novel T to C SNP in the promoter region at position -198 (rs11102930) and rs6330 which was found to be associated with anxiety-related personality traits and has been suggested to may affect intracellular processing and secretion of NGF.


3 rs222747

Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow: 1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population 2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.


4 rs4364254

Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow: 1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population 2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.


5 rs4693608

Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow: 1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population 2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.


6 rs6330

3. NGF gene: A novel T to C SNP in the promoter region at position -198 (rs11102930) and rs6330 which was found to be associated with anxiety-related personality traits and has been suggested to may affect intracellular processing and secretion of NGF.


7 rs6856901

Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow: 1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population 2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.


8 rs8065080

Eight polymorphic SNPs in the three different genes suspected to be involved in LPV has been examined as follow: 1. HSPE gene: Four polymorphic SNPs: rs4693608, rs11099592, rs6856901 and rs4364254 that were found to be informative in the Ashkenazi Jewish population 2. TRPV1 gene: Two polymorphic SNPs: rs222747 and rs8065080.



HPO Nodes