SNPMiner Trials by Shray Alag


SNPMiner SNPMiner Trials (Home Page)


Report for Clinical Trial NCT01924052

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

CGRP Induced Migraine Attacks in Patients With High and Low Genetic Load

The investigators hypothesized that migraine without patients with many genetic loci associated with migraine (high genetic load) would be more sensitive and get provoked more migraine attacks by calcitonin gene-related peptide (CGRP) compared to patients with few genetic loci associated with migraine (low genetic load).

NCT01924052 Migraine Without Aura
MeSH: Migraine Disorders Migraine without Aura
HPO: Migraine Migraine without aura

1 Interventions

Name: CGRP

Description: Calcitonin-gene-related-peptide (CGRP)

Type: Drug

Migraine patients with high genetic load Migraine patients with low genetic load


Primary Outcomes

Description: The difference in incidence of migraine-like attacks between patients with high genetic load and patients with low genetic load using verbal rating scale (VRS).

Measure: CGRP induced migraine attacks in patients with high and low genetic load

Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP

Secondary Outcomes

Description: The difference in area under the curve (AUC) for headache intensity scores (0-12 hours)

Measure: CGRP induced migraine attacks in patients with high and low genetic load

Time: Change from baseline in headache intensity at 12 hours after the start of infusion of CGRP

Allocation: Non-Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs13208321

One of the genetic loci (rs13208321) is located in a gene (FHL5) that is associated with the regulation of cAMP-responsive elements.



HPO Nodes


HPO:
Migraine
Genes 181
TWNK COL5A2 RPS15A GDF2 RPL35A AMACR RPL11 RPL18 SRPX2 RNASEH1 CCR1 SLC2A1 SLC1A3 GP1BA FGFR3 TREX1 ND1 OPA1 MLH1 TRNH COL4A1 PMS2 TRNS2 TRNS1 GP1BB POLG2 ACVRL1 PRRT2 KCNQ2 KCNA1 ND4 HTR1A KCNQ3 SCN8A RPS29 ERAP1 TRNK TRNL1 MSH6 ATP1A2 POLG COX2 ENG FAN1 TWNK TRNQ TRNQ GRIN2A PRRT2 SLC1A3 KRAS SMAD4 TRNS2 ND6 MSH2 NLRP3 GP9 GATA2 CACNA1A PIK3CA SLC2A1 RELA SCN8A TRNS1 FGFR2 CACNA1A APP GATA1 RPS20 TRNV TWNK CACNA1A RPL15 COX3 SMARCB1 FAS RPL26 RPL27 ADA2 RPS7 GCDH RRM2B ENG COL1A1 POLG IL12B TRNL1 PGK1 TLR4 SCN1A SLC6A19 SCN2A COX1 MYD88 PRRT2 STAT4 MVK VHL RPS24 TRNW PEX11B NFIX RPL5 TRNC HLA-B TRNF NOTCH3 ND1 RPS10 PDGFB SH2B1 PDGFRB TRNW COX3 GABRG2 NF2 NDP PGK1 GPR101 CACNA1A CYTB TNFRSF1A EPCAM CSNK1D APP TWIST1 RPL35 ESR1 SLC25A4 KLRC4 ADAMTSL1 IL10 MYORG TNF COL5A1 TGFBR2 SEMA4A DNM1L UBAC2 TWNK HLA-B PRRT2 COX2 ADA2 NOTCH3 C4A BMPR1A NOP56 EDNRA IL12A-AS1 RRM2B IL12A IL23R RPS19 ACSF3 C11ORF95 RPL31 TSR2 MLH3 ND5 NLRC4 ND6 MEFV AIP RPS26 ACVRL1 RPS17 RPS27 COX1 TREX1 ND5 COL3A1 TRNF POLG RPS28 CACNA1A FGFR3 PMS1 STIM1 SMAD3 MLX
Migraine without aura
Genes 4
CSNK1D ESR1 EDNRA TNF