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Report for Clinical Trial NCT02633475
Developed by Shray Alag, 2020.
SNP Clinical Trial Gene
Association Between Interleukin-10 Promoter-1082A/G Polymorphism With Idiopathic Recurrent Miscarriage Risk of Chinese Han
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han. A total of 100 women with IRM and 100 control women with a successful pregnancy will be included in this study. Then genotyping will be performed.
NCT02633475 Abortion, Spontaneous MeSH: Abortion, Spontaneous Abortion, Habitual
HPO: Spontaneous abortion
1 Interventions
Name: IL-10 polymorphism
Description: The IL-10 genotype will determined by polymerase chain reaction (PCR) amplication and restriction length fragment polymorphisms.Type: GeneticCASE: patients with IRM CONTROL: women no miscarriage
Primary Outcomes
Description: Identification of genetic polymorphisms that are associated with idiopathic recurrent miscarriage
Measure: genetic polymorphisms associated with idiopathic recurrent miscarriage Time: within one year (plus or minus 1 month) after surgerySecondary Outcomes
Description: To explore the differential indexes in the routine blood test and blood coagulation test between patients with idiopathic recurrent miscarriage and healthy women, such as: WBC, NEU, LYM, RBC, HB, RDW, MCV, PLT, MPV, PDW, PCT, Fib, D-dimer.
Measure: Indexes in the routine blood test and blood coagulation test Time: During pregnancy and three months after miscarriageTime Perspective: Cross-Sectional
Case-Control
There is one SNP
SNPs
1 rs1800896
The IL-10 polymorphism -1082A/G (rs1800896), which is located in the promoter region of the IL-10 gene, was reported to be implicated in the abnormal expression of IL-10 in IRM by some studies.