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Report for Clinical Trial NCT03518294

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

NASH Fitness Intervention in Thrombosis Trial (NASHFit)

Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States. The most advanced forms of NAFLD are associated with increased liver-related mortality and lower overall survival. The current standard of care for NAFLD is lifestyle changes through diet and exercise. The human genome and regulation of gene expression is influenced by physical activity. NAFLD is a prothrombotic state with derangements in all three phases of hemostasis leading to clinically important clotting events. Exercise can improve coagulation in healthy persons. In this proposal, we seek to begin a line of work to answer the question "Can lifestyle changes effectively mitigate the increased risk of clotting in patients with NAFLD?" focusing initially on the at-risk population genetically susceptible to advanced disease.

NCT03518294 Liver Diseases Blood Disorder Digestive System Disease
MeSH: Liver Diseases Gastrointestinal Diseases Thrombosis Hematologic Diseases Digestive System Diseases
HPO: Abnormality of blood and blood-forming tissues Abnormality of the gastrointestinal tract Abnormality of the liver Decreased liver function Elevated hepatic transaminase

1 Interventions

Name: Aerobic Exercise

Description: Subjects in the aerobic exercise group will be supervised to exercise 30 minutes, 5 times per week at a moderate intensity. Formal exercise instruction and supervision will be provided by ACSM certified fitness professionals at the Penn State University Fitness Center. Aerobic exercise can be completed on either the treadmill, exercise bike, rowing machine or the elliptical machine.

Type: Behavioral

Aerobic Exercise


Primary Outcomes

Description: The primary outcome of interest is change in fibrinolysis as measured by PAI-1 level immediately following completion of the exercise program.

Measure: PAI-1 level

Time: 5 months

Secondary Outcomes

Description: hemostatic marker

Measure: Change in von williebrand factor (vWF)

Time: 5 months

Description: hemostatic marker

Measure: change in p-selection

Time: 5 months

Description: hemostatic marker

Measure: change in protein S

Time: 5 months

Description: hemostatic marker

Measure: change in factor VIII

Time: 5 months

Description: hemostatic marker

Measure: change in fibrinogen

Time: 5 months

Description: hemostatic marker

Measure: change in antithrombin

Time: 5 months

Description: hemostatic marker

Measure: change in protein C

Time: 5 months

Description: fibrosis marker

Measure: change in adiponectin

Time: 5 months

Description: genotyping subjects (GG, GC and CC genotypes)

Measure: Patatin like phospholipase-3 (PNPLA3) rs738409 polymorphism

Time: 5 months

Description: hemostatic marker

Measure: Change in PAI-1 stratified by PNPLA3 genotype

Time: 5 months

Description: measured by magnetic resonance imaging proton density fat fractionation (MRI-PDFF)

Measure: change in % hepatic fat

Time: 5 months

Description: hemostatic markers

Measure: correlation between VO2 max and hemostatic markers

Time: 5 months

Description: quality of life

Measure: health related quality of life (HRQOL) change

Time: 5 months

Description: fibrosis

Measure: change in hepatic fibrosis stage

Time: 5 months

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs738409

Patatin like phospholipase-3 (PNPLA3) rs738409 polymorphism.

Patatin like phospholipase-3 (PNPLA3) rs738409 polymorphism (GG, GC and CC genotypes) plays a crucial role in the development of NAFLD.



HPO Nodes


HPO:
Abnormality of blood and blood-forming tissues
Genes 1848
PIEZO1 TNFRSF11A HBA2 BIRC3 PRKAR1A KIT COL5A1 ATRX CYP11B1 CASP10 PIGL F2 TET2 ATRX LMBRD1 LAMA3 SLC40A1 KIT GLI1 PROC HMCN1 PEPD EPB41 CASP10 NBAS NGLY1 ABCA1 NEDD4L WAS MARS1 REN ENPP1 PLG LRP5 GBA TREX1 DYNC2LI1 RPS14 TNFAIP3 TINF2 TYROBP ADAMTS2 NPC2 CYP7B1 BLK KCNJ11 CYB5A HIRA SLC19A2 GP1BA RNASEH2C ANKRD26 SLC22A4 CD3G BUB1B TAF1A DOCK8 GDF2 HLCS SPTA1 SMPD1 BCOR HLA-DPB1 NDUFS1 PET100 BCR APP JAK2 SSR4 IL10 IFNG SLC17A5 MLLT10 BCL11B NOTCH3 BMPR1A CALR RAG2 CDAN1 FCGR2A NDUFAF2 COG6 SUFU RUNX1 ACP2 IFNG ITGB4 SDHC HPRT1 ISCU COL5A1 MTTP SMAD3 TGFBR1 CD247 MET IGH GFI1B ATP6V0A2 COA8 DNMT3A VWF RPS26 ACVRL1 VPS33B GATA1 FOXE3 NCF1 TAL1 RECQL4 SMAD4 TPP2 RNU4ATAC ITGA2B SDHA SH2B3 PRKACG PDGFB PIGM ERCC4 C1R RMRP ALG6 WIPF1 CD81 F7 ADAMTS2 NOS3 GATA6 CHD7 SMAD4 SRP72 DOCK8 FLI1 BRCA1 TAZ SLC2A1 TERT HBA2 NDUFB8 HBB GATA1 TMPO MTOR MTHFR CR2 HAVCR2 SERPINF2 MYH6 SDHB AKR1D1 CD59 NHLRC2 MPI DCLRE1C GLB1 TMPRSS6 KRIT1 STK4 NEBL SAA1 NDUFA12 EWSR1 COG4 ACTN1 MYORG SDHD EPHB2 MRAS AGGF1 GTF2E2 SMAD3 ESCO2 TGFB1 GPI PDGFRB RNASEH2A CEBPE TGFBR2 DGKE MTFMT APC ABCB7 ITGB3 FCGR2C KIT F9 ABHD5 RAD54L GFI1 SPATA5 GLA SLC30A10 MAP2K2 NDP PIK3R1 CTSK STIM1 KLF1 VHL COL7A1 CST3 SFXN4 HBB DPM2 SLC25A13 RAD51C RMRP ANK1 KCNJ11 CD40 DLD LRP5 ATM COL5A2 RPL35A PSEN1 BCL10 LPP CCR1 ERCC2 GP1BA HBA1 JAK2 ACAD9 TFR2 FANCD2 ATP6V0A2 IREB2 KIF15 SOS1 NEXN STT3B F11 ATRX CTRC TGFBR2 PTPN11 HPS3 HBA1 PTEN RS1 WIPF1 NDUFS3 TNFRSF1B LBR SLC37A4 CXCR4 KIT TNFRSF13B CYSLTR2 CORO1A TRNQ PTPN22 TRNN CD55 ALG12 MEFV CCM2 SCARB2 FANCI GP9 NT5C3A UMPS WAS CD247 ANKRD1 GFI1B AK2 MAD2L2 RFXANK ELMO2 CARD11 PTH1R ACTC1 MYH11 SMARCAL1 JAGN1 LYST MSH2 GPR35 FANCA NSMCE2 CYBC1 HLA-DPA1 LBR ANKRD11 SLX4 RAG2 KRT14 DPM1 CLCN7 FARSB RNASEH2A SPARC CISD2 DNAJC21 TGFBR2 ADA PLVAP AKT1 KMT2D NOTCH1 GCLC TNFRSF1A IL7R IL10 FUT8 RFWD3 TMEM67 NPHP1 BRAF CYP7B1 ACAT1 RFX5 ITGB3 MTRR MLH3 MLF1 PRSS1 POLE ACSL4 FARS2 RASA1 MTAP VPS13B CUBN ALPL IGHM SDHB CFTR PALB2 COL3A1 GFI1 GBA HNF1A F5 MMADHC ATP7A FECH ABCD4 ACD ITGB3 HRG ZNF469 TREX1 NCF1 LPIN2 GGCX CD3E BUB1 TBXAS1 EFL1 SGCG MCM4 ERAP1 CLCN7 MSH6 GNAQ COPA HAVCR2 NOTCH1 PEX12 SH3GL1 F13A1 SPINK1 IGH DOCK6 HABP2 LRRC8A TERT RPS27 RNF43 ITGB3 RARA GSS HBG2 FCGR2B TNNC1 NCF2 NLRP3 PDX1 TNFRSF13C ERCC3 WAS EVC CTLA4 MYPN CD79A BLOC1S6 CCND1 ZBTB20 TRNS1 BRCA2 AIRE NCF2 TERC CCND1 HLA-DRB1 HBB RPS24 NR1H4 KRT5 MVK ACP5 TXNRD2 DAXX NUP214 TET2 TINF2 ACAD8 MVK EOGT KRT14 DNAJC19 MTHFD1 PEX16 ND1 PIK3R1 OCRL ADAR PIK3R1 MPL PRLR TMEM127 MYH9 TCF4 GNAS HBA2 SEMA4A A4GALT FCGR2C WDR19 APPL1 RUNX1 ACTN4 C4A PSAP BMPR1A B4GALT1 NFKB1 FANCC SRC MEFV RPS17 KRT14 RIN2 VCL KIF1B GBA MVK TRNT1 PLN MMUT UBE2T KLHDC8B FGA RANBP2 GTF2H5 SPINK1 SBDS FERMT3 CYP2C9 COX15 ARPC1B SPINK5 NLRP3 COG4 FHL2 RNF168 SGCD ZBTB24 NTHL1 PEX12 GINS1 TERT HYOU1 CASR NPHP4 IRF2BP2 MMACHC FANCG SEC63 CSF3R BAP1 ERCC4 CDKN2A LRP5 PLOD1 PDE11A PLAT KLF1 TCIRG1 PARN BCR HSD3B7 COL7A1 IFNGR1 PKLR RPL15 RFXAP TRMU SLC4A4 RPS17 SDHB ASAH1 SLC7A7 GP1BA SLCO2A1 DNMT3A HLA-B ORAI1 DHFR STEAP3 FIP1L1 SLC4A1 SPTA1 CALR BAP1 LAMTOR2 PRF1 SERAC1 KCNN4 ABCC8 LCK NPM1 ITK TAL2 IFIH1 TNXB COL5A1 AMMECR1 COX20 ATP7A FANCI FAH JAK2 PHKG2 GALC TNFRSF13C SEC24C RPL31 TGFB2 ITGA2 IL2RG CCND1 NUMA1 FUCA1 ATR FLI1 APP MMP1 CA2 CACNA1D SPTB KRAS SMPD1 TUBB1 SPTA1 VHL CAPN5 RPL11 HBB-LCR GP1BA PEX14 TBX2 EPB42 GYPC SMARCB1 CORIN DOCK2 FANCA LAMB3 CD79B AMN LYST ABCB7 GNAQ DTNBP1 PDGFRA SLC30A10 GBA GBA LMAN1 GNAS HBB PROC STS FANCB FECH MMUT DBH PFKM RFT1 KRIT1 KRAS SMAD4 TACO1 AP3B1 LCAT NLRP3 GATA2 SEMA3E ATM RPL5 ADAMTS13 AMMECR1 PACS2 FASTKD2 HBB SPP1 PRF1 ATP7B GCNT2 SPTB ARHGEF1 CASR KCNE5 ALDOB CD3D CYB5R3 F13B BEST1 BCL10 PSMB4 CPT2 GCLC PTPN22 PDCD10 COX1 COL14A1 SP110 TERT NUMA1 CFTR C4A NDUFA13 PRKACA CD27 FANCC IDH2 SLC46A1 EVC2 RFT1 LPIN2 TCAP TGFB2 FOXN1 RREB1 RNU4ATAC STK11 SCN11A APC TET2 SDHA BTK PDGFRA SCO1 CD81 RET PANK2 PRKCD ATP6AP1 COX10 NLRP1 HBG2 PHGDH PTPN11 TNFSF12 KAT6B FLT1 ADA EGLN1 KRAS CLCNKB PRTN3 COL3A1 SLC39A13 FGB DNAJC19 RIT1 KIT KRT5 GP1BB LDB3 DDX41 NDUFA4 NPHP4 CLPX F13A1 RPL11 NUP214 NFKB2 CLCN7 TARS1 ND4 MYH7 GNAS TERT DLL4 CALR NDUFAF3 PLEKHM1 COL4A1 LMBRD1 THRA GBA TACO1 IRX5 ATOH7 SEC61A1 TNFSF11 SLC19A2 KLF1 IDH2 TBX1 NEUROD1 THPO PML PANK2 ANK1 GATA2 NPM1 NDUFS7 CACNA1S G6PD LAT SOS1 LYRM7 ANGPTL6 GFI1 NBN TNNI3 LARS1 APP GATA1 USB1 FAS HPRT1 TBXA2R F10 TAZ MLH1 MUC1 HPGD COL3A1 FGG GNB1 PROS1 ACD KDM6A ALG2 FBXL4 FYB1 NPC1 CPOX USP8 GLB1 CYP11B2 IL10RA ABCC9 EXTL3 TET2 JAK2 GBA FGFR2 CFI COL1A2 WRAP53 GP6 TALDO1 HBB SRD5A3 KCNJ11 PIGT ABL1 FANCE COL3A1 FANCM MAX PRKG1 IGHM RAF1 FLNA F12 CFI PGM3 CYP4F22 AAGAB IL12A PSMB8 PDHA1 TNFRSF1B PSEN2 PDGFRB PNP APOE CR2 TMEM165 LAMC2 BRAF FAT4 F8 CD19 SALL4 UROD TNFSF11 PTPN22 AKT1 SLC2A10 SGPL1 CYBA TTC37 JAK2 PSMB9 GP1BB KRT14 TERC EXT2 F13B TRAC TSR2 PFKM OCLN HBB NLRC4 FANCE LYST HBG1 TBXAS1 ABCG8 TGFB3 CYP2A6 APOB TRNW FAM111A NDE1 DCLRE1C TPM1 IL7R COL4A5 NOD2 ARFGEF2 NDUFA10 IL2RG RAG1 PIK3CA DNM2 TCF4 TERC NDUFV1 GNA14 GALT SLC2A1 STAT1 ANK1 FANCF SLC25A38 AKR1D1 WAS PGM1 IL2RA PGK1 LIPT1 ATM CRYAB STAT4 IKZF1 ATRX SLC35C1 SH2B3 MYH9 SH2D1A CCND1 VPS13A CDC42 UBR1 ADA2 SCO2 CYP26C1 NDUFA9 ASXL1 ALAS2 HLA-DRB1 C15ORF41 RPS14 GATA2 CDH23 NBN EPCAM NHP2 MMADHC CBLIF SRP54 DKC1 TPI1 RECQL4 CD28 GLB1 IRAK1 DGUOK MMUT BLOC1S3 ENG TGFBR3 ABCC6 TSR2 PTEN NCF4 NRAS PHKA2 FERMT1 MAN2B1 FLT3 SERPINF2 MMP1 PICALM PIK3CD APOA1 CP LAMB3 IVD GNE ATRX STIM1 IKBKG TERT SAMHD1 RBM8A DNMT3B PHF21A NFKB2 TMTC3 MPL RPL18 CLPB FLNA ETV6 TP63 RTEL1 OPA1 CTC1 TREX1 PROS1 STAT3 RMRP SF3B1 CFTR SERPINE1 COL4A1 DOLK SLC25A11 XRCC4 PRKCD HBB CCM2 COQ2 PIGA CFHR1 MPL LRP5 HMGCL TNFRSF4 CA2 FZD4 TERC PMM2 HTRA2 KIT RAB27A CBS PLA2G4A GUCY1A1 VKORC1 WFS1 RPS7 IL2RB COX8A MMAB ALG8 NUTM1 DIAPH1 RBM20 TP53 LEP PUF60 TRNF CYBA TBL1XR1 EP300 COX14 GNA11 F5 TF COL7A1 TINF2 RBPJ THBD ICOS CLDN1 KIF11 PEX5 BPGM PLAU LZTR1 SLC4A1 SLC46A1 PTPRC FGB RYR1 PLEC RPS28 ARVCF CLCN7 NBN MST1 CFH SLC11A2 FGG TMEM127 CD28 HAX1 MRPS7 CD8A AMACR RAF1 SDHA CHST14 JMJD1C ND5 ELANE HELLS APC FLI1 HPS5 STAT3 ADAM17 TTC37 RHAG ATP7B BLNK SHPK CYB5A BLNK FOXP1 MAT2A F7 BUB1B PEX2 GNAQ PMS2 MSH6 ACTN2 MPLKIP AIP POMP CPA1 ITGB2 BCS1L LRBA DNMT3B EFL1 VHL RPSA RUNX1 FANCD2 DES USP18 CLCN7 BRD4 XRCC4 MSH2 NPHP1 SNX10 JAK2 MAP2K1 COL17A1 ALAD AK1 APOE NDUFAF5 SMPD1 ITGA2B IDH1 CTLA4 SCN10A PEX11B SDHD GATA1 NPM1 RPS20 SLX4 USP8 PRKAR1A PROC JAK2 MPL SRD5A3 FOXP3 COL1A1 PSMB8 FGA MTR HPS4 HBA1 CSRP3 MSH6 CCBE1 OTULIN PGM3 SCN9A FANCL FLNA HLA-DRB1 COX3 FLNA TP53 RBM10 STN1 SDHD CIITA GSS WRAP53 TET2 HLA-B RAC2 COX2 DNAJC21 FAS TINF2 EPAS1 RPS29 LIG4 OSTM1 MAP1B IFT140 RPS19 SSR4 GP1BA BTNL2 SPTA1 CRIPT SDHA GDNF STAT3 ACVRL1 SPTA1 PTEN DLL4 ZBTB16 FOXRED1 GNAS ABCC6 COX4I2 RB1 RNASEH2B STAT5B NLRP3 NHP2 GATA1 G6PC3 COL7A1 LIG4 NF1 YARS2 COL1A1 AK2 RASA2 SLC35A1 MS4A1 LIG4 PUS1 NRAS APOE STOX1 RFWD3 GGCX PADI4 UROS HBA1 ANO6 RAF1 NOP10 LIPA RFXANK STXBP2 TRNT1 HLA-B HBD HBG1 NHP2 GSN PCNT VWF HOXA11 ALX4 BMPR1A NDUFS4 XK PIGL STAT4 CYB5R3 GBA F9 XYLT2 EPG5 HSPA9 TET2 SLC29A3 ABCC2 PEX3 ATP11C NAXD BRCA1 GATAD1 BMPR2 ELANE EPO CFH ITCH RET SBDS KLKB1 RPL26 HOXA11 BCR STAT1 SLC35A1 CASP10 TERT TRIP13 MYD88 GLA CYCS GP9 ACVR1 COLGALT1 HAMP PTEN CD244 TNXB RPS10 GCK SMARCAL1 COL4A2 CIITA BCL2 ZNF341 MAX PALB2 PUS1 TGFB3 LEPR RAG2 CD46 SLC27A4 IKBKG ETHE1 PDGFB LAMTOR2 RPL26 ITGA2B RAG1 CBFB BLM UMPS INHBA CASK CALR IL23R VPS13B SNX10 SLFN14 PIK3CA CTLA4 ND6 STT3B WT1 COG1 STEAP3 ADA ATP7A LMNA KCNQ1 DLST ZAP70 LOX UFD1 F2 EIF2AK3 TCF3 STAT3 RAG2 TAZ NBN EPO RPS15A NAGS TCIRG1 RYR1 SDHAF2 F13A1 FADD CXCR4 RBM8A NF2 CARD11 ATP6V1A LMNA FLT3 PEX13 RPS29 F10 CTC1 SDHB NF1 KIF1B PNPO CD70 MPL TPMT MPL FAS ICOS HBB NSD1 PLEKHM1 TFAM SH2B3 SDHC VPS33A CYP4V2 G6PC PRKAR1A THBD MPDU1 CISD2 SLC4A1 C1R RNASEH2B RPS19 ARMC5 PDE4D DPAGT1 CAPN3 CEL MYC TP53 ALDOA PLOD3 CBS FGB RAG1 CEBPA SCARB2 LBR HNF4A GPX1 UBE2A ACTA2 KRAS RAC2 UBAC2 TINF2 CD4 PDCD10 RAG2 CTNNB1 RFXAP HBB MAD2L2 PET100 PRF1 COL1A1 FKBP14 SRSF2 SARS2 ERMARD PNPO FGA FGA MMACHC MYD88 PRKCSH TET2 CTRC RTEL1 EPOR RRM2B KIF23 GATA1 TONSL JAK2 RHOH DCLRE1C ERCC6L2 MECOM EPHB4 RPL35A TBC1D24 MSN NIPBL NFKB1 NFIX JAK2 SF3B1 TYMP F2 COL5A2 DSG2 GREM1 ARF1 FAM111A RFX5 SBDS HBB RASGRP1 NOP10 GATA2 ENG SURF1 C1GALT1C1 IRAK4 HBA2 MECOM SLC19A3 MPL PEX19 AEBP1 CLPB HBA1 CBL FKBP14 LBR RRAS2 FN1 GPC1 IL2RG PSTPIP1 BMPR1A HBB KRT5 COX6B1 ENG TBCE ATP6V1E1 MFAP5 FANCF NRAS LARS2 KLF11 ADA2 GCDH SURF1 RPS7 IL12B FOXN1 IFIH1 PLOD1 SMAD4 MDM2 USB1 MYH7 LIG4 PRDM5 AGXT SAMD9 ABCD3 SCN5A PGK1 NDUFS2 CIITA SEC23B PRSS1 MSH2 SRP54 APP CLN3 XPR1 CFHR3 STX11 FGG DNASE1 PLEC SLC17A5 IL12A-AS1 THPO NABP1 TSC1 HBG1 FH FANCG PHGDH DNAJC21 TCN2 SPTB RPS26 SLC39A13 GATA1 CD3E ELANE RPS27 TCF3 SLC29A3 MYBPC3 F9 COMT SAR1B CD151 AGA ABL1 BMS1 POLG KRT1 STIM1 BCL11B PLEC SLC7A7 ITGA2B CST3 SERPINC1 MGAT2 MYSM1 TRNH SLC20A2 PEX10 IDH1 MPL ALAS2 GP1BB APP DMD SRP54 NHEJ1 TRNL1 SLC25A15 ALAS2 CP MAGT1 RAD51 TNFRSF13B PRLR TREM2 GP1BB SBDS SKIV2L VPS13A ACAD9 PRF1 TTC7A SC5D FANCB JAK3 CHIC2 DDOST PAX4 RTEL1 VHL NLRP12 TRNS1 TDP2 BRAF CAD IL7R XRCC2 CD19 FTCD CYBB RIN2 PTPN11 KIT KCNJ1 PLEC HSD3B7 SMAD4 RPL5 SOS2 BRCA2 TCF4 RRAS SERPINC1 TRNW F11 UNC13D DOLK C1QA RPL35 TSC2 KLRC4 KIF1B P2RY12 IKZF1 ADAMTS3 EPB42 DKC1 STK11 ELANE SAMD9L RPL15 NLRC4 RPS15A FASLG CREBBP GATA2 CTRC XYLT1 PPCS HBG2 SPINK1 ETHE1 C3 PRKAR1A PRDX1 KCNJ5 RPL18 FBN1 KRAS ARHGAP31 PRSS2 COA8 ECHS1 NBEAL2 FASLG INS ABCC8 TBXAS1 PTPN22 AASS TCIRG1 NEU1 VKORC1 SLC2A1 ATRX BAG3 RHAG RPL27 FAN1 CBL HK1 CTNNB1 BMPR1A CFB ERBB3 SALL4 PTPN11 PARN ITGA2 RARA FGG RNF113A HELLPAR PMM2 ABCC6 TEK ICOS TNFSF12 CHEK2 FZD4 GLRX5 MDH2 FMO3 TTC7A PRSS2 ENG PCCB TALDO1 TET2 HPS6 SLC4A1 AGK ALDOB PKLR TNFRSF13B MYC COG8 PTF1A COL1A2 RPS10 SAMD9L BCL10 HBB POT1 NDUFS2 VPS45 ABHD5 WAS PTEN TGFB1 SIK3 PEX26 BUB3 AMMECR1 HLCS RAD54B SLC4A1 DNM1L MYLK SLC2A1 WFS1 LIG4 NFKBIL1 ADAR DNASE1L3 CAP2 PLEC MPO ELN DKC1 HMOX1 SETBP1 TTN COL7A1 AP3D1 PKLR ETV6 PMS1 TCN2 FGB ATP7A TEK FIG4 F5 CFHR1 GDF2 ITGB4 AHCY CARD9 RASGRP2 HMGCL CYBB NDUFA2 RAG1 TREX1 MLH1 COL4A1 CTPS1 CDCA7 TNNT2 LMNB2 TF SDHC RAG1 PEX1 FKTN CD79A TFRC C1S PRDM16 PIEZO1 FOXP3 KIT A2ML1 CD3D PROS1 MMAA NDUFAF6 ARL6IP6 CTLA4 NSUN2 CTLA4 XIAP TRNS2 LIPA BCL6 EPB41 NDUFV2 HBA2 RHBDF2 IGLL1 FBN1 HPS1 UNC119 ARHGAP26 JAK2 RAG1 ERF SH2B3 CFHR3 PARN GALT SC5D FAS RPL27 TLR4 SF3B1 FDX2 PRKCD RPS24 LAMA3 KCNQ1 UBE2T C2 TERT SLC12A3 CD109 RHAG LAMC2 MCFD2 XIAP MPIG6B GGCX CHD7 IGH BLM SERPIND1 FH LAMA4 HADH RNASEH2C SMARCD2 B2M STING1 TGFBR1 CD36 PEX6 CD40LG ZMPSTE24 CD46 ITGB4 BRIP1 RAB27A ADA2 ABCB6 GATA1 NBEAL2 SAMHD1 MLH1 PRSS1 PMS2 ASXL1 MALT1 UROS BRIP1 FANCL TCIRG1 YARS2 ABCA1 MTRR PCCA CEP57 VWF TP53 TBX1 RPS28 KCNE1 NDUFS8 SMAD3 MLX
Abnormality of the gastrointestinal tract
Genes 2002
GPC3 ALG13 LETM1 CACNA1A NFKBIA UBR1 FAT4 NONO CPLANE1 RNASEH1 ORC1 ALS2 QDPR MYPN CHRNE F2 MSX1 TERT LMNB1 KIT ORC4 SDHD BAP1 YWHAG C2CD3 GDNF SLC18A3 GBA NGLY1 NEDD4L POLG FGF8 PSAP WAS SCN3A PTCH2 ENPP1 PLG TRMT10C CDKN2C LRP5 TWIST2 INPP5E AXIN2 TREX1 GABRG2 SPG7 ASXL1 POLG TNFAIP3 COMP PPM1D PIGV TYROBP DDC NPC2 CYP7B1 BLK PTDSS1 SPINK5 HIRA GBA SPG7 GBE1 MEN1 CEP57 GP1BA WDR60 AP1S1 NRXN1 CD3G BUB1B DOCK8 EXT2 SEMA3C NECTIN1 SMPD1 HLA-DPB1 KAT6B MYH7 MEFV SF3B4 JAK2 SSR4 IL10 ATXN3 BMPR1A RAI1 PIK3C2A B3GLCT COG6 PODXL IGF2 CLCN4 STN1 ITGB4 SDHC SH2B1 IL12RB1 COL5A1 MTTP RNF6 NONO TMPRSS6 LONP1 KIT GTF2I CDC45 MID2 CCNQ GFI1B IGF2R RPGRIP1L RET MATR3 SLC6A5 ACVRL1 GABBR2 NCF1 RECQL4 PMS1 DLL1 SLC52A3 ITGA2B ND4 CHRND CCR6 DACT1 GATA6 ALDH18A1 DCHS1 TBX3 JUP ERCC4 C1R MED17 RMRP SIX3 PRKN TRNE TWIST2 F7 ADAMTS2 SDHB GATA6 CHD7 SMAD4 BRCA1 FLNB MAP2K2 PANK2 NDUFB8 KCNC3 GREB1L TRAK1 HFE KLHL7 POT1 AKR1D1 GPC4 TBP MPI TTBK2 MATR3 TOP3A WWOX MED12 CDH1 DLG1 HESX1 KIAA0586 KCNA2 SAA1 L1CAM PFN1 EWSR1 EDN3 COG4 SCN4A KIAA0319L SLC52A2 PACS1 EFEMP2 DYSF AGGF1 POLR3A ATP1A3 MAP2K1 CNKSR2 POLR3A FGF12 TGFBR2 TWNK RAD51C FBXO7 FBLN5 MINPP1 LRRK2 KCNK9 APC FCGR2C WWOX AFF4 ZAP70 NTRK2 SEC23B SOX10 WDR34 GLA MYH11 SETD5 TCOF1 KCNJ11 SLC30A10 MAP2K2 GATA6 COL7A1 ATP6 CLTC SLC25A13 RAD51C DDX59 POGZ SLC6A8 SYNJ1 COL5A2 IL1RAPL1 MID1 FRG1 CCR1 SON GP1BA PAX3 STRA6 SYT14 GAS1 TMEM70 ATRX RFC2 APC PTEN WIPF1 KIF1A PIK3CA EDN3 DNAJB6 CSPP1 TP53 SLC37A4 TNFRSF13B TERC TRNQ SDHD MTTP CD55 IDS ATXN7 SCARB2 FANCI GP9 MKKS RET CDK4 BSCL2 VANGL1 MAD2L2 SMAD7 BRCA2 AGTR2 RFXANK SOX5 NOD2 PRKAR1A RET WDR4 GPR35 FANCA CYBC1 ABL1 HLA-DPA1 LBR TARDBP ANKRD11 NUP214 SLX4 MTOR PANK2 MKS1 FARSB OSGEP CISD2 DNAJC21 PLVAP CDH1 KMT2D NOTCH1 PPP2R3C SMC1A TP53 EDNRB TNFRSF1A SMG9 SOX10 TP53 SLC25A4 LBR RFWD3 HLA-DRB1 B3GALT6 CYP7B1 BUB1 CCR6 PIK3R5 TSPYL1 ACTA1 ELN SLC10A2 RFX5 ATXN10 ATXN8 ITGB3 MLH3 HTRA2 PALB2 SLC2A2 SKI MFF RNASEH1 MLH3 ATP13A2 SHANK3 CAVIN1 KIF5A KANSL1 IGHM CHEK2 MCM6 TNPO3 DGAT1 HNF1A SLC13A5 F5 KAT6A ATP7A ABCD4 ACD AKT1 ITGB3 ITGB4 NCF1 SNAP25 WASHC5 ND3 POLG2 GUCY1A1 PLXND1 BAAT CD3E BUB1 CENPF EFL1 SLC9A6 MRPS34 AFG3L2 PDGFRA ERAP1 SYP PRNP MSH6 APC SRCAP NOTCH1 PEX12 SPINK1 IGH ZIC2 DOCK6 PLG PIGO SLC25A24 PAX3 SOX10 DMD LRRC8A BRAF RNF43 BIN1 DLC1 ITGB3 MEGF10 EXOC6B POLR1C SPG11 HNRNPH2 VAC14 NCF2 FTSJ1 ATXN1 PDX1 KIAA0556 CACNA1A PQBP1 SNAI2 CTLA4 CD79A FTL H19 BRCA2 AIRE NCF2 POLG2 MECP2 APC AKT1 KLHL40 HLA-DRB1 PGAP3 RELA GPC4 MVK HNF1A CHAMP1 DAXX TET2 EOGT CDC73 MITF PEX16 ND1 MUTYH PIK3R1 GABRA5 OCRL BBS1 AXIN2 TCF4 ADD3 FLAD1 OTC PTPN3 CHMP1A VAMP1 SEMA4A PIK3CA FRAS1 APPL1 FLII REV3L C4A FKRP FA2H SOX2 BMPR1A USP9X NFKB1 FANCC WRN CNTNAP2 MEFV WNK1 GYS2 PKHD1 RHBDF2 TRAPPC11 PHOX2B NTNG1 NEB ATP6V1A GBA RB1 CDH11 UBE2T SLC35A2 TUBB6 DACT1 FGA SIK1 ND5 SBDS PNLIP RECQL4 ERCC2 ARPC1B SPINK5 RAI1 PARS2 POU2AF1 BRCA2 IQSEC2 ZBTB24 PKD1 NTHL1 PEX12 TERT PLEC ATXN8OS SLC52A3 HYOU1 MYLK PROKR2 TCTN3 ATP2A2 STXBP1 FGFR2 KEAP1 LAMA2 SEC63 WT1 USP9X ERCC4 KIFBP CDKN2A RELA HSD3B7 COL7A1 LAMC2 ERGIC1 FLVCR1 GLI3 PIK3CA RFXAP FOXF1 CDH1 L1CAM IL1B H19-ICR PITX2 PORCN SDHB SLC7A7 TRIM28 CDKL5 GP1BA SLCO2A1 SELENON CYP7B1 LINGO1 SI BMP2 BRCA2 HLA-B PAK1 PIGW LMOD3 IQSEC2 MEN1 NPM1 MAP3K7 TNXB COL5A1 JAK2 TMEM216 RET ASAH1 SNCAIP COG7 ADAR FAH PHKG2 TNFRSF13C SEC24C MYO9A CCND1 MYO1H CDKN2A SLC9A7 FLI1 CDKL5 DDHD2 ALDH18A1 MMP1 MYH8 ZNF81 PYROXD1 NAA10 SACS APC ASPA REST TDGF1 C12ORF65 IL1RN HMGA2 ASCC1 PEX14 SNCA CORIN GNS SERPING1 LAMB3 CD79B CHMP2B PRDM16 FOS PTF1A PHOX2B GNAQ GEMIN4 PIEZO2 B9D1 STUB1 CAV1 STS FANCB RARB STX1A LIPA ARMC9 BCOR KRAS BCOR SMAD4 EDNRB PRSS1 NOTCH2 SEMA3E IRF5 CEP41 TK2 SKIV2L MUTYH ATM TBCE SPP1 GBA JAK3 ATP7B CARS2 CDKN1A POLA1 PHOX2B CDC6 ALDOB TRIM28 SPINT2 ACTA1 F13B SNAI2 RAPSN CCN2 ADNP TMEM231 FKTN LEMD3 PTPN22 COX1 COL14A1 SP110 ZEB2 CNTNAP1 SLC25A1 SLC5A7 PCGF2 AHI1 NOTCH3 CFTR REEP1 KCNQ1OT1 MYOT TMEM237 SLC5A1 SLC46A1 LPIN2 BRIP1 TGFB2 RREB1 STK11 TGFBR2 TP63 AXIN2 SIN3A PLAGL1 CNTNAP1 APC TIMM8A MYT1 BTK CCDC22 DSP PDGFRA GDF3 CD81 TECPR2 SYT2 PANK2 FRMPD4 RRM2B PLAA FGFR2 C11ORF95 EIF4G1 PHGDH CHRNE PDGFRL TNFSF12 TPM2 FLT1 TSPAN7 BUB1B LMNB1 VPS35 TUBB4A CDC73 SKI PRTN3 COL3A1 TP63 APC MBTPS2 DYNC2H1 GP1BB NUP62 PCSK1 SDHC ZFYVE26 TRNW F13A1 RPL11 ND6 ZNF41 SUFU TBP NFKB2 WDR35 FANCB TRNV ND4 CAMK2B WASHC5 UBA5 PRKCG NDUFAF3 EDNRB PHOX2B SLC25A13 GBA DLG3 IRX5 DPP9 SIX6 SLC19A2 ADAMTS3 FOXG1 ASCL1 SERPING1 IDH2 AGRN TBX1 NEUROD1 ACTG2 MSH3 GTF2IRD1 VANGL1 CDKN2B SALL4 PRKRA PEX16 PANK2 ARX MSH6 LRRK2 MECP2 DNM2 GFI1 NBN TNFSF15 HDAC8 COL18A1 PITX2 DMPK MCEE USB1 MAPT SETD5 DDIT3 HPRT1 CHRND AGA F10 MLH1 AMER1 POLE HPGD ORC6 GRIN2D HMGA2 FGG CCDC47 KDM6A FBXL4 NALCN ROR2 NPC1 IFNGR1 MAP3K7 PGAP2 RPS6KA3 NEUROG3 GLIS3 IL10RA SMC1A EXTL3 CAVIN1 ATXN3 WNT2B SIX1 ZFP57 AXIN1 EPHX1 KCNJ11 VARS1 FANCE MYORG FANCM IGHM MITF ZNF423 FLNA TCF4 KLHL41 PIBF1 AAGAB IL12A ELP1 FLCN SLC37A4 ECM1 PIGN CR2 NCAPG2 MASP2 ARNT2 MET ARHGEF6 POLR3A DGUOK FAT4 LRP2 DYNC2H1 TUBB4A CD19 SALL4 ACADVL PTPN22 TRIP13 SLC2A10 CYBA AARS1 GBA2 SDHC TTC37 JAK2 NSD2 GP1BB MAGEL2 TERC EFTUD2 VPS13C SPART VCP HBB NLRC4 ENPP1 NEB LYST PIGL RTTN MYO5B CRKL CYP27A1 CPLX1 SOX10 SETBP1 PARN ATXN3 DCTN1 HIVEP2 STUB1 PIGO PIK3CA ARFGEF2 RFX6 PIK3CA PSTPIP1 SERPINA1 TCF4 RETREG1 KRAS IL6 EPCAM STAT1 SLC35A2 GDNF KLHL41 TRNL1 ITGB4 AKR1D1 WAS SHH SMC1A MCOLN1 IL2RA PABPN1 RET FBN1 STAT4 NEK9 IKZF1 ATRX CCND1 VPS13A RAD21 HABP2 KLHL7 H19 UBR1 ADA2 ATXN8OS NEB NAB2 SCO2 MAPK1 MYF6 EPCAM ELP1 HSPA9 SLC6A8 NHP2 SZT2 CBLIF SRP54 DKC1 TPM3 NOP56 NUP133 ACTL6B ST3GAL5 IRAK1 GRIP1 PLCG2 IRF1 ABCC6 PTEN NCF4 QDPR BCR PHKA2 FGFR2 FERMT1 KCNAB2 KCNB1 MMP1 IRF5 PTPRJ ARL13B FAT4 ATRX TERT DNMT3B ATRX TMTC3 MPL ARID1B PLAA GMPPA MGMT FLNA HNF1B ZFPM2 CYP27A1 ATXN3 RTEL1 OPA1 MBTPS2 GPHN STX3 EPCAM AGPAT2 PORCN CTC1 KLHL40 ADH1C FRAS1 FH TGIF1 HMBS ANTXR2 SLC18A3 NEK1 MPZ SALL1 RMRP CFTR TAF1 ZSWIM6 CFTR GABRA2 XRCC4 FOXC1 PRKCD RNF43 SDHB SNCA IRF2BPL PIGA TGFB1 ASCL1 ZMPSTE24 DICER1 ECE1 DNAJC6 AP1S1 PAH SFTPA2 WDR73 FBN2 PLA2G4A SLC2A10 SALL4 WFS1 CACNA1G IL2RB RRM2B TRNL1 HOXD13 EYA1 MPI STAC3 ALG8 KAT6B PUF60 TRNF NDUFA9 CYBA DOK7 EP300 ACD UCHL1 COL7A1 GLI2 EDN3 RBPJ DCC PEX5 HYLS1 CEP104 KIT PTEN SLC46A1 FGB SNRPB NEB REPS1 NOTCH3 CDKN1C BARD1 SPIB ARVCF BACH2 RLIM RAD51 MST1 TMEM237 PIGV SYT14 SLC25A22 VAMP1 AMACR IGF2 CHST14 JMJD1C F12 MEN1 RAD51 CEP41 ARHGAP29 ND5 MMEL1 HELLS FCGR2A SLC6A3 APC SLC5A7 POLG SUFU SHROOM4 ZIC3 STAT3 ADAM17 SOX2 TTC37 NRTN BLNK SHPK KIAA0586 TP53RK PEX2 GJB2 TPM2 PMS2 MAPT GNAS INPP5E FREM1 TCTN2 ERLIN2 ITGB2 C19ORF12 STAT6 MNX1 SDHB NGLY1 LRBA DNMT3B KRAS POLG EFL1 COL13A1 LAGE3 GDNF FANCD2 TMEM237 CACNA1B DLEC1 NODAL CARMIL2 MSH2 CCNQ SFTPC HMBS NEUROD2 CHD4 EDNRB SPRTN ZIC3 CLMP KRT18 ITGA2B VAPB WHCR POMT2 PEX11B KRAS RAI1 ITGA8 VAMP1 RPS20 LAMB3 SYNGAP1 FOXP3 DDX59 MEIS2 ACTG2 COL1A1 SYNJ1 POLG CHRM3 CTNNB1 MDM2 NEXMIF FGFR1 MECP2 FGA GABRB2 PSAP TPM3 ABCC8 BMP4 RERE MSH6 CCBE1 ATXN8 EDN3 PGM3 NEXMIF NDUFS3 FANCL FTL GLRA1 HLA-DRB1 COX3 FOXF1 FLNA RBM10 STN1 SLC6A9 DSP POMT1 SDHD ALDH18A1 WRAP53 NOP56 NUS1 RAD21 POLD1 HLA-B MAFB COX2 DNAJC21 FAS DCTN4 POLR1D FREM2 EEF1A2 RRM2B MAP1B BTNL2 SLC9A6 GPC3 SDHA POLG ACVRL1 FGFR2 DLL4 SPG21 SLC25A13 HRAS PIK3CA NECTIN1 ABCC6 PPARG SLC52A2 COX4I2 KITLG TWIST1 XRCC1 NEFH ATXN2 COL7A1 ACTG2 DHDDS OTX2 REEP1 AK2 SCN8A MS4A1 MYH3 KCNA2 EDNRB APC MKKS ATP11A PALLD STOX1 RFWD3 OPTN ARL3 PLA2G6 HYMAI TCTN1 NOP10 LIPA RFXANK UROD PLA2G6 TYMP HLA-B SLC52A3 CDK4 TARDBP NHP2 ATN1 BMPR1A TWNK PTS TGFBR1 POLR3B STAT4 MECP2 PTS DVL3 RPL10 KIF7 XYLT2 CCBE1 SOX10 AP2S1 ABCC2 PEX3 MACF1 ACTB MAPT ITCH SBDS CFC1 PIGY MYCN INTU STAT1 FGFRL1 CASP10 HLA-DRB1 RAD21 TRIP13 MYD88 B3GLCT CLMP DNM1 ALS2 GP9 AICDA GLMN COQ4 SERPING1 PTEN TNXB FGF20 GCK ELN CLCN4 PYCR1 CIITA FLCN KLF6 PALB2 SNCA GRHL2 SYT1 TGFB3 ELN HCCS PSPH DIS3L2 ATP6 MITF ITGA2B BLM INHBA SLC19A3 HDAC8 HTT IL23R POLG NBN GRHL3 HCCS TAF1 UPB1 NOTCH2 MSH2 ND6 SLC39A4 SETX FOXG1 WT1 TJP2 MC1R ATP7A MYO5B IRF6 HLA-B ATP1A3 KBTBD13 ACTA1 CLCN1 ZAP70 EPRS1 UFD1 EIF2AK3 NBN ATP1A3 MSR1 CC2D2A ECE1 CAMTA1 LIFR TMEM67 FLVCR1 ATP8B1 SERPINH1 CXCR4 RBM8A TGM6 LRP12 AP3B2 LRP2 APC PEX13 ARX PDP1 TAF1 CTC1 SCN9A SDHB NF1 MAPT ACTA2 ARV1 DMP1 ALS2 DGUOK TPRKB CDH11 SOX2 GRM1 FAS NDUFAF2 AAAS TXN2 G6PC CHAT CISD2 DCHS1 POLR3B CHRM3 ATXN7 C1R BRCA1 RPS19 CFTR TFAP2A HCN1 APC F5 COX7B STAG1 KMT2A CEL MYC TP53 TBK1 CCN2 CBS POLE AKT1 WNT7A POLG FGB IRF6 VAC14 ABCA3 LBR DIS3L2 TGFBR2 MRE11 HNF4A FAH ALS2 TANGO2 AR TRNK EDN3 RAC2 UBAC2 TINF2 ERLIN2 ITGA6 CNKSR2 CTNNB1 RFXAP HBB NPHP1 FREM1 CXORF56 KLHL41 PMS2 DDHD2 ERMARD TGFBR2 RECQL4 MYMK RAB39B AMACR ADCY6 PRKCSH TBK1 CDKN1B CTRC PTEN CSPP1 PTCH1 RRM2B KIF23 GATA1 JAK2 PPP2R5D HCFC1 DCLRE1C MTMR14 TIMM8A TBC1D24 DNAJC13 NIPBL CDKN2B TYMP GREM1 ARF1 CDON RFX5 RAD51D FUS RASGRP1 NOP10 SCN3A CEP290 MUSK SOD1 ENG DHCR7 COLQ PTRH2 MYO9A CTNNB1 SCN4A WNT4 RPGRIP1L UBA5 PEX19 FGFR3 SMC3 TBCD GPC1 BMPR1A DISP1 ENG LMOD1 SNAI2 FANCF ND2 DKK1 CRYAB KLF11 C9ORF72 DDOST EDN3 SURF1 ABCB1 OPLAH IL12B PLOD1 SLC9A3 SMAD4 SLC6A19 ACOX2 SEC23A CLCA4 MLXIPL BRAF MDM2 TOP3A CLIP2 DHCR24 POU6F2 UBTF SFTPA1 CTBP1 TRIP4 UBB LARGE1 ABCB4 LIG4 SH2B1 SHANK3 PAK3 BRAF SAMD9 NDUFS2 CIITA COQ2 PRSS1 MSH2 MMP21 SRP54 GMPPA TBL2 FGG PLEC EMC1 PTCHD1 SH3KBP1 STXBP1 NPHP3 TRMT5 IL12A-AS1 IARS2 RARS1 TSC1 MKS1 FANCG MEOX1 ARID2 NDUFS1 FXN TRAPPC11 PSEN1 ASCC1 TCF3 SLC29A3 GUCY2C DLX4 MED12 F9 SEMA3D LAMB2 COMT SAR1B CDKN2A SKI POLG GPC3 GJB6 SRCAP TRAPPC12 NUP88 TWNK SPECC1L FLCN HFE TRNH PEX10 IDH1 FCSK PIEZO2 RAD51C FGFR1 GP1BB CHN1 APP FGFR3 PACS1 SRP54 TRNL1 CEP120 AAAS KRAS KMT2A RAD51 FREM1 UBQLN2 TREM2 GABRD FREM1 GP1BB SKIV2L POLD1 VPS13A B4GALNT1 ARSA NR4A2 OSGEP CAV1 CD96 EDNRB TTC7A FANCB JAK3 DDOST CACNA1G PINK1 PAX4 POLG RTEL1 MECR NEK1 FARS2 IL21 SETX TRNS1 CHAT TK2 RNF125 CTHRC1 NDUFA6 ASXL1 MLH1 CTNND1 XRCC2 FIG4 FBLN5 PNKD TERT GNA11 RIPK4 CYBB NIPBL VAMP1 HPCA WT1 ARX ATXN1 IFT80 KIT MAPT SAR1B HSD3B7 PITX2 CEP120 SMAD4 HNRNPU KIT PLP1 BRCA2 TCF4 TRNW CHCHD10 F11 SLC6A3 TGFB1 AHI1 C1QA GDF6 TSC2 IL12A KLRC4 ALG3 ADAMTS3 PLG SCN4A USP9X DKC1 GLI3 SMAD4 STK11 LMNA PRPS1 ELANE POGZ ERLIN2 WNT3 RSPO2 FANCB GDNF DNAJB6 NDUFB11 EBF3 FASLG CREBBP RPS6KA3 CTRC LTBP4 XYLT1 ALDH18A1 PMPCA SPINK1 WDR73 SDHC HOXB1 PRPH BAZ1B EHMT1 ARHGAP31 PRSS2 INS ANTXR2 SQSTM1 PMP22 WFS1 MED12 ABCC8 NXN TCIRG1 SPG7 RERE DACT1 DLL4 CHRNG MSH3 NEFH ATRX KCND3 GDAP2 UBE3B FGFR2 FAN1 NECAP1 SMC3 CC2D2A IRGM GLUD2 BMPR1A GCH1 FLNA SALL4 MUTYH ARNT2 PARN ITGA2 EP300 ISL1 ABCC6 TEK SQSTM1 TERF2IP ICOS MECP2 TNFSF12 CHEK2 FOXG1 PDE8B TWNK FUS MKS1 PCNA TTC7A TRNK IRF5 MYRF ENG CTNS MNX1 RIPK1 CASP10 CYFIP2 LCT NPHP3 RPL10 GMNN PHOX2B JAG1 TNFRSF13B DEAF1 COG8 BCL10 UPF3B KCNQ1 TMEM67 PTCH1 SCN4A PEX26 BUB3 RET COL25A1 PARK7 ACTA1 COG4 PIEZO2 GRIN2D DNM1L SLC1A2 PLEC SMO MSX1 WFS1 LIG4 TP53 RAD50 MAPT TSPYL1 IL10RB TPM3 ACTA1 HGSNAT SETBP1 MSH2 NALCN COL7A1 MLH1 RTEL1 FOXH1 MBTPS2 COLQ USP27X HNF4A PIGN H19 FMR1 FMR1 PMS1 TBX4 ATP7A TMEM138 TJP2 TEK FIG4 GDF2 AHCY NUP107 SLC30A2 CYBB DHODH BDNF TK2 GLRB RYR1 KY FUZ BRCA1 MLH1 ACTB SLCO1B1 MUC5B CDCA7 LMNA SDHC ATXN8OS MTM1 GDI1 SDHD PEX1 SRC CHEK2 RYR1 FGFR2 PIEZO1 FOXP3 ITGA6 RET EXOSC9 HDAC4 INPP5E EP300 PDGFRB CEP120 NSUN2 TGFB1 MYOT AFG3L2 TRNS2 BMPR1A LIPA TBX3 GNAO1 TPM3 NPHS1 RHBDF2 IGLL1 CAV1 DAB1 HPS1 CHCHD10 FOXE1 SIN3A LIMK1 NUP62 MYOD1 ABCB11 ERBB2 LAMA3 FGFR2 CCDC28B TRIP4 FAS CACNA1A DHCR7 DPYS SPG21 ND1 TLR4 ACOX1 PIGN PRKCD LAMA3 CASP8 HFE CDH1 CD109 LAMC2 NCF4 NRAS XIAP ZNF711 PPP3CA ATXN2 CDKN1B PRKRA FLNA WNT3 TP63 MGME1 GIGYF2 B2M KLLN ATAD1 COL13A1 KCNK9 PEX6 SEC23B FGFR1 SMO FAM13A COX7B HRAS SEMA3E PRSS1 GPIHBP1 NRXN1 SALL1 PALB2 CHD7 BRIP1 FANCL NDUFB11 YARS2 SOX3 CHRNA1 GFPT1 SLCO1B3 SDHB TBC1D23 CEP57 VWF TP53 KRT8 ACSL4 TBX1 GJB1 CHRNA1 SNCA SMAD3 KIFBP TTC7A MLX
Abnormality of the liver
Genes 1378
CLDN1 GPC3 LETM1 MPL PIEZO1 UBR1 TNFRSF11A CLPB IL17RA HNF1B CCDC115 CYP27A1 CTSC TRIM37 BTK AGPAT2 CASP10 ATP8B1 SDCCAG8 HMBS TREX1 POU1F1 C8ORF37 RMRP SF3B1 WDPCP PAX8 KIT CFTR XRCC4 PRKCD NDUFB10 LMNA ATP8B1 TMEM67 KRT8 PCSK1 HMGCL NSMCE2 PEPD CA2 EPB41 NBAS NGLY1 UQCRB TERC IFT172 ABCA1 PMM2 NPHP3 PSAP AP1S1 MARS1 TTC21B TRMT10C CDKN2C LRP5 GBA NDUFAF5 TREX1 CBS WDR19 SUMF1 KRT17 MKS1 PNPLA6 NDUFV2 TINF2 TBX1 IL2RB NPHP4 NPC2 TMEM67 CYP7B1 CEP290 HOXD13 COX8A MMAB BLK MPI PHKB WDR19 ALG8 HIRA TRIM37 GBA CYP7A1 GBE1 ALG9 WDR60 GNPTAB RNASEH2C AP1S1 NRXN1 LMNA CYBA PEX5 KCNH1 LHX3 COX14 ATPAF2 SLC22A5 NDUFS7 TF GDF2 MPC1 SMPD1 PNPLA2 LHX1 PCCB RBPJ PET100 ICOS CTSA CLDN1 PEX5 KMT2E AP1B1 DUOX2 BPGM LZTR1 ASS1 SLC4A1 PTPRC TBX19 HAMP BMPR1A CDKN1C SPIB PIK3C2A ARVCF CALR ATP6V1B2 RAG2 CDAN1 ABCA1 ITCH B3GLCT MST1 COG6 SLC11A2 B9D2 IGF2 CD28 IDUA MRPS7 PEX13 SCYL1 AMACR IGF2 PEX12 JMJD1C IL12RB1 MEN1 MMEL1 FCGR2A NAGA FLI1 HSD17B4 SLC25A20 KRT6B CYP19A1 TTC37 RHAG CD247 RNU4ATAC TNFRSF1A ATP7B TMPRSS6 MET LDLRAP1 GTF2I HADHA BLNK SHPK KIAA0586 IGF2R COA8 PEX2 BCS1L PMS2 ACVRL1 VPS33B IYD UGT1A1 CPA1 HNF4A NCF1 BCS1L TPP2 RNU4ATAC STAT6 PCCA ND4 NGLY1 POLG ND2 ERCC4 PSAP EFL1 PDGFB PIGM ERCC4 RMND1 MIF TSHR BBS7 FANCD2 ALG6 USP18 MRPL3 PEX6 CLCN7 PEX10 ND1 NOS3 MSH2 GATA6 HMBS SMAD4 SNX10 SPRTN PKHD1 BRCA1 ZIC3 WDR35 ALDH7A1 ETFB PEX10 DUOXA2 ACADVL LETM1 TERT KRT18 APOE SMPD1 WHCR FGFR2 PEX11B INVS RPS20 PRKAR1A CR2 HFE MPL SRD5A3 HAVCR2 CC2D2A AKR1D1 HNRNPA2B1 SLC25A13 NHLRC2 COX15 GPC4 MPI DCLRE1C PSMB8 CTNNB1 DDRGK1 LDLR SGSH KRIT1 BTNL2 SAA1 ASL ALG9 PEX16 BTK MSH6 EWSR1 C4B WDR60 HPD COG4 PSAP MKKS BBS5 FANCL ALG13 MYORG HLA-DRB1 FOXF1 MRAS STN1 AGGF1 LHX4 PIGA TGFB1 GPI WRAP53 RNASEH2A TGFBR2 DNAJB11 DNAJC21 FAS APOA1 ZAP70 DCTN4 APC OSTM1 RRM2B C1S IFT140 DPM2 DGUOK BTNL2 GPC3 ABHD5 SOX10 HADHA PEX11B PEX3 SDHA WDR34 TARS2 NDUFAF1 ACVRL1 DYNC2LI1 DLL4 SLC30A10 GATA6 CTSK KLF1 SLC25A13 ATP6 PIK3CA ALG1 DPM2 PPARG COX4I2 TBX19 SLC25A13 RAD51C RMRP FGA ANK1 SLC5A5 NHP2 DLD G6PC3 CSPP1 HJV NDUFB3 APOB SON RASA2 HBA1 MS4A1 SLC25A15 APC LIG4 ACAD9 TFR2 PALLD APOE SOS1 STOX1 RFWD3 RFC2 CTRC LIPE MCCC1 UROS HBA1 HADHB RAF1 NOP10 LIPA RFXANK STXBP2 UROD TNFRSF1B HLA-B SUMF1 TP53 HBG1 SLC37A4 NHP2 FBP1 PCK1 XK TWNK SDHD SLC25A20 TRNN CD55 IDS IL17F MEFV SLC39A8 LTBP3 FANCI GBA RPGRIP1L PRPS1 PSAP DCDC2 HLA-DRB1 NSD2 PEX6 TET2 BSCL2 SLC29A3 ARSA MAD2L2 ABCC2 PEX3 COG2 ATP11C ABCB11 RFXANK LRPPRC SFTPC TMEM216 CFH ITCH PRKAR1A SBDS LYST LZTFL1 PEX14 GPR35 INTU FANCA STAT1 NSMCE2 CYBC1 LBR FGFRL1 CD96 SLX4 CASP10 RAG2 RPGRIP1L TERT MYD88 UGT1A1 IDUA NOTCH2 DPM1 FAN1 CEP55 CLCN7 HAMP BTD CC2D2A MKS1 CEP83 FARSB RNASEH2A BBS2 GCK ELN DNAJC21 CIITA BOLA3 PALB2 GCLC HADHA MKS1 IL7R PKD2 MICOS13 NAGLU SLC25A4 CD46 LBR TMEM67 DIS3L2 MOGS CYP7B1 PNPLA2 ACAT1 CASK ELN UQCRC2 RFX5 SNX10 IL6 COG8 MLH3 JAM3 NDUFV1 CTLA4 CLCN7 ABCB4 PRSS1 WT1 PPARG STEAP3 ADA TG LMNA PLIN1 XYLT1 ZAP70 UFD1 CAVIN1 EIF2AK3 CFTR CC2D2A TNPO3 TWNK GBA NAGS TMEM67 HNF1A F5 TCIRG1 APOE ATP7A FECH WDPCP ATP8B1 NCF1 ND3 NPHP3 RBM8A POLG2 TSC2 NDUFS7 OFD1 LMNA EFL1 UCP2 PEX13 SLCO1B1 MCM4 ESCO2 CLCN7 CTC1 SDHB MSH6 APC CEP290 PLPBP NOTCH1 PEX12 CYC1 CD70 CASR DOCK6 PLG TMEM70 KCNH1 ARSA LRRC8A FAS ICOS DCDC2 RNF43 PLEKHM1 TCTN2 TFAM VPS33A UGT1A1 HBG2 G6PC TTC8 ALMS1 NCF2 PDX1 GLB1 LIPT1 TNFRSF13C B9D1 PEX5 GANAB CARS2 BBIP1 PEX11B FADD CD79A SLC4A1 BRCA1 RNASEH2B TRNS1 TRNE H19 NEK8 BRCA2 CFTR AIRE NCF2 POLG2 APC F5 NDUFS3 APC TERC DPAGT1 CCND1 HLA-DRB1 CEL MYC PROP1 ALDOA GPC4 NR1H4 ARL6 MVK TRHR DDRGK1 HNF1A CBS DAXX TET2 MVK EOGT DNAJC19 PEX16 TTC21B C8ORF37 IFT27 PIK3R1 TERT SCARB2 LBR PC ADAR HNF4A FAH PEX14 IL36RN TANGO2 BBS1 PEX2 POLG2 NPHP3 PEX1 TCF4 HBA2 PIGS SLCO1B3 TRNK ACOX1 NPHP1 PEX26 PTPN3 WDR19 PEX2 SEMA4A MFN2 TINF2 ETFDH APPL1 GNPTAB PSAP RAG2 AGPAT2 RFXAP HBB USP9X NFKB1 FANCC KCNJ11 IL2RG CNTNAP2 LMNA GYS2 PKHD1 RECQL4 ERCC8 GBA AMACR KRT18 HMGCS2 MYBPC3 GUSB VCP PEX13 SP110 PRKCSH CDKN1B TET2 CSPP1 MMUT UBE2T FBP1 RRM2B KIF23 JAK2 PEX1 IER3IP1 DZIP1L SPINK1 ND5 GUSB SBDS PEX1 FERMT3 ABCG8 LYRM4 B2M JAK2 DPM3 NLRP3 POU2AF1 BRCA2 TYMP LYZ PKD1 PEX12 BSCL2 RFX5 IDUA HBB RASGRP1 NOP10 HYMAI HYOU1 CASR ENG DHCR7 HBA2 IFT172 NUBPL PTRH2 CEP19 KCNN3 CC2D2A TMEM199 RPGRIP1L PEX19 ADK SEC63 WT1 SURF1 ERCC4 HNRNPA1 VIPAS39 RRAS2 BCS1L KLF1 GPC1 TCIRG1 RELA COX6B1 HSD3B7 CPT2 COX15 TSHR IFNGR1 CPT2 PKLR PLAGL1 FANCF ND2 SDHA HEXB NRAS RFXAP KLF11 MECP2 INPP5E TRMU NDUFA11 IFIH1 H19-ICR ASAH1 SLC7A7 TRIM28 SLCO2A1 CLCA4 MLXIPL CLIP2 BMP2 BRCA2 DMD DPM3 POU6F2 DHFR CTBP1 STEAP3 PARS2 SERPINA1 NDUFS2 SPTA1 PRF1 ABCB4 INSR LIG4 CEP290 PAX8 ABCD3 KCNN4 TMEM107 SDCCAG8 CIITA SEC23B MUC5B PRSS1 NPM1 ITK MSH2 SEC63 SRP54 IFIH1 XPR1 IFT172 SLC13A5 STX11 JAK2 TBL2 ALMS1 KRT6A COX20 ABCG8 BSCL2 SLC17A5 NPHP3 TRMT5 COG7 FAH PHKG2 ABCC2 POMC TNFRSF13C SEC24C FANCG IDUA IL2RG PEX26 GALNS SLC40A1 FUCA1 TRAPPC11 TSFM SPTB CD3E GNE TCF3 SLC29A3 PEX3 COMT CA2 SAR1B AGA CDKN2A CLEC7A SKI SPTB POLG KRAS GPC3 SMPD1 REST SPTA1 SLC7A7 AKT2 IFT122 PEX14 SPECC1L FAM111B EPB42 GYPC HFE GPD1 SLC20A2 PEX10 CORIN GNS ALAS2 CD79B PEX6 PRDM16 FOS BBS10 PDGFRA SLC30A10 NDUFAF3 MPV17 HADHA GBA IL1RN GBA BBS1 GNAS HBB SLC25A15 CAV1 XRCC4 CPT1A PEX13 FANCB KRAS STX1A FECH RAD51 SCYL1 TNFRSF13B MMUT LIPA NDUFS1 GABRD ANTXR1 ADAMTSL2 GP1BB PEX14 POLR3A COG1 SKIV2L VPS13A PFKM RFT1 KRAS ARSA SMAD4 PPARG DIS3L2 INPPL1 NDUFS4 ACAD9 AP3B1 NOTCH2 NLRP3 GATA2 TTC7A SC5D AKT2 SKIV2L JAK3 DDOST ADAMTS13 PRKCSH PAX4 RTEL1 VHL FASTKD2 HBB NEK1 NDUFA6 ALG8 RPGRIP1 ATP7B NPHP1 INSR IL7R OFD1 SPTB CDKN1A CASR PEX1 XRCC2 CD19 PEX10 ALDOB TRIM28 PCSK9 RPGRIP1L ANKS6 CYBB PSAP TPO PSMB4 CPT2 LIPE WT1 APOC2 IFT80 PTPN11 KIT ARSB SP110 AGL HSD3B7 NDUFS6 ASAH1 PEX19 SOS2 CFTR KCNQ1OT1 NKX2-5 CD27 PEX12 RFT1 RRAS NDUFB9 LPIN2 RREB1 GCGR TGFB1 PEPD UNC13D RNU4ATAC STK11 DOLK LONP1 TIMMDC1 APC IL12A BTK BCS1L PDGFRA SCO1 FOXRED1 PHKG2 CD81 EPB42 DKC1 SMAD4 STK11 PRKCD ACSF3 C11ORF95 ATP6AP1 IFT80 COX10 CEP290 NLRP1 TMEM126B HBG2 NLRC4 COX10 DYNC2H1 PDGFRL TNFSF12 KAT6B FLT1 TMEM216 ADA FASLG IFT43 NDUFAF2 TREX1 CTRC DNAJC19 BMPER SPINK1 RIT1 BBS9 ERCC6 NDUFA1 MPV17 TMEM67 BAZ1B POLG KRAS TRNW LACC1 GALK1 ARHGAP31 COA8 ND6 BSCL2 HNF1A CIDEC FASLG INS NFKB2 WDR35 ABCC8 TRNV NEU1 RERE IQCB1 PLEKHM1 DLL4 ACADM SLC25A13 RHAG ETFA TRMU SLC26A4 GBA TACO1 CPT1A TNFSF11 HNF1B IL17RC FAN1 TBX1 UGT1A1 NEUROD1 RBCK1 GTF2IRD1 CDKN2B HK1 CTNNB1 POLD1 G6PD IFT140 ERBB3 C1QBP PARN LARS1 ALG11 ARSA HELLPAR PMM2 TNFSF15 LCAT ICOS TNFSF12 DMPK GLRX5 USB1 NAGA FAS IL21R TTC7A SLC39A4 AGA FBN1 PYGL MYRF PRSS2 ENG MLH1 ABCC8 CTNS PCCB PEX3 TALDO1 HPGD NDUFAF4 NPHP3 SLC4A1 ALDOB CCDC47 JAG1 COG5 PKLR TNFRSF13B COG8 MRPS16 TSC1 ALG2 FBXL4 EIF2AK3 FUCA1 NPC1 CPOX GLB1 NEUROG3 KCNQ1 GLIS3 VPS45 ABHD5 EXTL3 WDR34 CAVIN1 PTEN TRIM32 GBA FGFR2 CFI PEX26 TALDO1 HBB AXIN1 SRD5A3 KCNJ11 UGT1A1 COG4 IDUA FANCE FANCM IGHM SLC2A1 TRAF3IP2 PEX6 HJV TRAF3IP1 HNF1B TP53 POU1F1 CEP120 SLC22A5 PSMB8 TNFRSF1B SLC25A19 DNASE1L3 PEX26 PDGFRB SLC37A4 HMOX1 HGSNAT SETBP1 CR2 ACADL CEP164 TMEM165 HADH SFTPA2 MET AP3D1 ACADM LRP5 HNF4A H19 NDUFB11 EARS2 PEX3 PMS1 BRAF ATP7A BBS12 IFT172 TJP2 KRT16 ABCG5 DYNC2H1 GDF2 AHCY CD19 ACADVL GUCY2D HMGCL DLD TNFSF11 CYBB GNMT TRIP13 SLC40A1 GAA CYBA DHDDS ABCB4 RAG1 TREX1 TTC37 JAK2 MLH1 PSMB9 NSD2 WDR35 SLCO1B1 LMNA LMNB2 SDHC TERC CAV1 RAG1 PEX1 OCLN HBB FOXP3 CIDEC PLIN1 LYST PEX5 BCHE A2ML1 INPP5E ABCG8 CD3D CYP27A1 COG2 MMAA CPLX1 TRNW PEX2 SETBP1 CTLA4 DCLRE1C HESX1 TGFB1 CTLA4 XIAP IL7R LIPA TMEM67 NOD2 NELFA IL2RG RFX6 EPB41 RAG1 TRAPPC11 SLC25A1 RHBDF2 IGLL1 PIK3CA POMC LMNA SERPINA1 LIMK1 GALE TSHB ABCB11 DYNC2LI1 NDUFAF1 GALT SLC2A1 CCDC28B GALT ANK1 SC5D SLC35A2 TRNL1 PEX12 WDR19 DHCR7 AKR1D1 PGM1 IL2RA TMEM231 ND1 BLVRA NDUFS8 ACOX1 ATM FDX2 MRPL44 IKZF1 PRKCD ATRX CASP8 HFE MYH9 SH2D1A PEX16 PCK2 PEX19 H19 ADA2 RHAG HNF4A NAB2 XIAP CDKN1B CHD7 LPL FH ALAS2 C15ORF41 TRAF3IP1 HADH RNASEH2C EPCAM SLC25A19 PEX16 PEX6 NHP2 CD40LG ZMPSTE24 PHKA2 RAB27A SRP54 DKC1 TPI1 TUFM CD28 ND3 GLB1 DGUOK MMUT GPIHBP1 PEX19 HADHB NCF4 NRAS PALB2 BRIP1 AUH PHKA2 TCIRG1 YARS2 BBS4 ABCA1 GFM1 SLCO1B3 KCNAB2 PCCA MAN2B1 IRF5 APOA1 KRT8 CP TBX1 GNE CPT2 NDUFS4 GCDH TERT SAMHD1 IARS1
Decreased liver function
Genes 225
UBR1 ND5 MPV17 POLG TRNW CCDC115 COA8 F13A1 ND6 SLC25A15 ACAD9 AGPAT2 PORCN TRNV POU2AF1 STT3B NDUFAF3 TRNT HADHB NOP10 LIPA GBA HLA-B TACO1 NHP2 PCK1 COQ2 CEP164 SLC25A20 TMEM199 TRNN RPGRIP1L PEX19 ADK PEX16 NHLRC1 NBAS IFT172 ALG8 MARS1 CACNA1S TRMT10C GPC1 PARN PEX6 BSCL2 LARS1 COX6B1 TNFSF15 PEX3 COG2 HSD3B7 CPT2 USB1 ND2 ITCH IL21R LARS2 DDOST TRMU GPR35 ENG CYP7B1 SURF1 COX8A NHLRC1 MPI ALG8 SLC7A7 ALDOB CCDC47 GBE1 JAG1 NPC1 FARSB PARS2 SERPINA1 COX14 CAVIN1 SMPD1 ABCD3 NDUFS2 PEX26 TALDO1 PET100 NPM1 PEX5 MEFV MICOS13 COG4 COX20 CYP7B1 COG7 FAH SPIB UQCRC2 PHKG2 MST1 MRPS7 SCYL1 AMACR IL12RB1 HADH ACADM MMEL1 EIF2AK3 PEX2 CC2D2A TJP2 TNPO3 TMEM67 GDF2 ATP7B IFT122 DLD F5 PTPN22 FECH RYR1 PEX14 COA8 TTC37 PEX2 JAK2 PEX10 ND3 FADD ACVRL1 MTM1 TERC PEX1 FOS SLC30A10 OCLN PEX13 BCS1L CTC1 ND4 SLC25A15 CAV1 INPP5E PEX12 CPT1A CYC1 FECH SCYL1 RMND1 LIPA VPS13A USP18 SMAD4 XIAP ACAD9 TFAM RTEL1 FASTKD2 ALMS1 LIPT1 NDUFB8 GANAB ATP7B FADD PEX11B GALT TRNS1 GALT PEX10 SC5D TRNL1 AKR1D1 F13B AKR1D1 MPI ND1 BLVRA HLA-DRB1 NR1H4 RNU12 SP110 PEX26 IKZF1 ATRX EPM2A ALG6 DAXX SH2D1A PCK2 PEX19 PEX16 COG4 SCO2 PEX10 FH FAH HADH POLG2 TCF4 TRNK WRAP53 OTC IL12A PEX6 ALG1 ALG9 TINF2 SCO1 DKC1 OSTM1 DGUOK BTNL2 COX10 HADHA PHKA2 GFM1 MOGS IRF5 ATP6 PEX13 PPARG CPT2 NDUFS4 TERT EPM2A DLD IARS1
Elevated hepatic transaminase
Genes 272
IER3IP1 SBDS MPV17 CLPB POLG HNF1B CCDC115 MS4A1 BSCL2 HNF1A ACAD9 TFR2 AGPAT2 NFKB2 DPM3 PALLD STOX1 TYMP TREX1 ACADM SLC25A13 HLA-B CPT1A SLC37A4 FBP1 HNF1B IFT172 TWNK ATP8B1 SDHD SLC25A20 RBCK1 TMEM199 HMGCL RPGRIP1L ADK NBAS NGLY1 PMM2 RPGRIP1L POLD1 MARS1 DCDC2 VIPAS39 TRMT10C C1QBP GPC1 BSCL2 LARS1 ALG11 HELLPAR PMM2 HSD3B7 CPT2 TREX1 ICOS TNFSF12 GLRX5 CFH PYGL TRMU GPR35 TMEM67 CYP7B1 NSMCE2 SLC7A7 DPM1 JAG1 FAN1 RNASEH2C COG5 TNFRSF13B COG8 MRPS16 NRXN1 BMP2 HAMP BRCA2 FBXL4 DMD DPM3 CC2D2A FARSB RNASEH2A SLC22A5 ABCB4 CAVIN1 GDF2 ABCD3 PNPLA2 CFI LHX1 PRSS1 SRD5A3 MICOS13 SRP54 IFIH1 COG4 SLC25A4 CD46 ALMS1 HJV HAMP CYP7B1 HNF1B TP53 PNPLA2 COG7 SLC22A5 FAH UQCRC2 RAG2 PHKG2 TNFRSF13C MST1 COG8 COG6 ABCB4 TRAPPC11 CR2 STEAP3 AMACR TMEM165 ACADM HNF4A SAR1B CAVIN1 HSD17B4 EIF2AK3 CDKN2A SLC25A20 CC2D2A POLG TWNK TMEM67 AHCY ATP7B CD19 HADHA ACADVL DLD F5 KIAA0586 GNMT DHDDS ABCB4 TREX1 JAK2 GPD1 PSMB9 CORIN WDR35 POLG2 ALAS2 VPS33B RAG1 FOS OFD1 SLC30A10 OCLN FOXP3 BCS1L MPV17 NGLY1 GNAS SLC25A15 POLG CAV1 INPP5E CPT1A ERCC4 CYC1 KRAS COG2 ALG6 VPS13A USP18 MRPL3 NOS3 ACAD9 TFAM SC5D DDOST G6PC TRAPPC11 SERPINA1 LIPT1 BRCA1 RNASEH2B ALDOB SRD5A3 SLC35A2 AKR1D1 POLG2 AKR1D1 PGM1 PSMB8 PSMB4 CPT2 DPAGT1 ACOX1 ATM NR1H4 MRPL44 SP110 AGL HSD3B7 IKZF1 PRKCD ATRX HFE CBS ASL MYH9 DAXX PEX16 MVK PEX19 CFTR DNAJC19 ADA2 HNF4A COG4 C8ORF37 LBR ADAR ALAS2 HADH RNASEH2C TANGO2 DOLK POLG2 TCF4 RNASEH2A PHKA2 DNAJC21 PHKG2 CD81 RRM2B SMAD4 DPM2 AGPAT2 ACSF3 DGUOK HBB NFKB1 ATP6AP1 HADHB ABHD5 PALB2 CNTNAP2 PHKA2 YARS2 GYS2 TNFSF12 FLT1 SLC30A10 SLC25A13 CTRC PEX13 DPM2 PPARG SLC25A13 GNE CPT2 CSPP1 SPINK1 RRM2B KIF23 SAMHD1 DLD IARS1