Excess weight is a major risk factor underlying leading causes of death globally, including cardiovascular disease, type 2 diabetes, and some cancers. Among participants assigned to the same lifestyle intervention arms in prior weight loss randomized controlled trials, large inter-individual differences in weight loss success have been observed, ranging from >50lbs of weight loss to >10lbs of weight gain. Both genetic and non-genetic factors underlying differential adherence and weight loss success are poorly understood.
Name: Lower carbohydrate dietDescription: Focused on limiting dietary carbohydrates, eating healthy fat and protein sources, and engaging in physical activityType: Behavioral
Participant chooses- Lower carbohydrate diet Randomized- Lower carbohydrate diet
Name: Higher fiber dietDescription: Focused on increasing dietary fiber, lowering fat intake from animal sources, and engaging in physical activityType: Behavioral
Participant chooses- Higher fiber diet Randomized- Higher fiber diet
Name: Physical activity focusedDescription: Focused on aerobic and resistance exercise, while following dietary guidelines
Participant chooses- Exercise focused Randomized- Exercise focused
There is one SNP
Primary aims include: a.) to confirm whether AG/GG individuals at MTIF3 rs1885988 lose more weight on lifestyle interventions; and b.) to test the performance of a randomized controlled trial vs. self-selection study design in terms of weight loss, drop-outs, and adherence.