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Report for Clinical Trial NCT03568773

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Influence of Polymorphysms in the Fto and Ppar Gen Genes, Systemic Inflammation and Oxidative Stress in the Magnitude of Weight Loss Induced by Intermittent or Moderate Continuous High Intensity Training Programs

The study focuses on the influence of polymorphism in the FTO genes rs9939609 and PPARᵧ Pro12Ala, oxidative stress and systemic inflammation on changes in body composition and rest metabolism induced by HIIT and continuous aerobic programs in obese or overweight individuals.

NCT03568773 Overweight and Obesity Chronic Disease
MeSH: Overweight Weight Loss Chronic Disease
HPO: Decreased body weight Weight loss

3 Interventions

Name: High-intensity interval training

Description: HIIT training is being conducted on a three-day weekly frequency on a stationary bike. The protocol consisted of two weeks of adaptation with 12 weeks of training that alternated between sprints ranging from 30 s to 60 s (> 95% VO2max), and active recovery ranging from 180 s to 120 s (30 W on the bicycle).

Type: Other

High-intensity interval training

Name: Aerobic exercise moderate intensity

Description: The aerobic training is performed in a walking or running mode, with three weeks of adaptation (2x / wk - 20 to 30 minutes / session, Type: Other

Aerobic exercise moderate intensity

Name: Control Group

Description: The control group is participating in lengthening classes to increase the adherence and control of the influencing variables. Classes are being held once a week for 60 minutes.

Type: Other

Control Group


Primary Outcomes

Description: The procedure used for analysis is done using a Dual Energy Radiological Absortiometry (DEXA) equipment. The measurement of the body fat and fat free mass percentage measure is obtained by means of a full body scan using the LUNAR PRODIGY DF + 14.319 Radiation (Madison, WI) brand device, following manufacturer's protocols. The body mass is evaluated by means of a balance (Sanny®, São Bernardo do Campo - São Paulo, Brazil), with the volunteer barefoot and in orthostatic position using a Toledo scale sensitive to 100 g. The stature is evaluated by a stadiometer with a tape calibrated at 0.1 of the same mark. Waist circumference and other body perimeters are measured with a 0.1 cm Anthropometric Tape (Sanny®, São Bernardo do Campo - São Paulo, Brazil). Weight and height data are used to calculate BMI using the equation adopted by the WHO: BMI = (Weight / (Stature) 2).

Measure: Body Composition. The changes are being evaluated.

Time: Before the intervention protocol and 48 hours immediately after the last exercise session.

Secondary Outcomes

Description: The metabolic rate was measured using a gas spirometry analyzer. After having fasted from 8:00 pm the previous day, the volunteers were referred to the laboratory shortly after the awakening and were invited to remain seated in a thermoneutral environment for 30 minutes. For the next 30 minutes, VO2, VCO2, VE and RER were monitored until variations of no more than 10% occurred when five-minute intervals were compared. Once this steady state was obtained, these variables were recorded for five minutes. The calculation of the resting metabolic rate is done according to Macdonald (1990).

Measure: Metabolic Rate of Rest. The changes are being evaluated.

Time: Before the intervention protocol and 48 hours immediately after the last exercise session.

Description: Collections of 10 ml of blood from the antecubital vein will be performed early in the morning, with fasting from 10 to 12 hours. The collections will be done 24 hours before, in the 6th week and after the intervention period. They will remain seated for 10 minutes for subsequent collection. Five milliliters of blood will be placed in EDTA-containing test tubes, protected from light and gently homogenized by inversion. The other 5ml will be placed in tubes without anticoagulants. They will then be centrifuged at 3,000 rpm for 10 min. The plasma or serum will be separated, placed in eppendorf tubes and refrigerated at -20 ° C until analysis. All analyzes will be carried out using a commercial kit of the Labtest brand (Minas Gerais-Brazil). The analyzes will be carried out on serum samples using commercial Labtest kits (Minas Gerais, Brazil), following the manufacturer's recommendations and on a Labmax 240 premium automatic analyzer (Lagoa Santa-MG, Brazil).

Measure: Lipid and Glycemic Profile. The changes are being evaluated.

Time: The collections will be done 24 hours before, in the 6th week and 48 hours after the end of the intervention.

Description: 10 ml of blood will be collected in the beginning of the morning, with fasting of 10 to 12 hours, being done 24 hours before, in the 6th week and after the intervention period. Five milliliters of blood will be placed in test tubes containing EDTA and protected from light and the other 5ml will be placed in tubes without anticoagulants and centrifuged at 3,000 rpm for 10 min. The plasma or serum will be separated, placed in eppendorf tubes and refrigerated at -20 ° C until analyzed by a commercial kit of the Labtest brand (Minas Gerais, Brazil). For this, 250 μl of sample will be added to KCl and incubated in a water bath (37 ° / 60 minutes). The mixture will be precipitated with 35% AA perchloric acid and centrifuged at 14,000 rpm for 10 minutes at 4 ° C. The supernatant will be transferred to eppendorfs and 400μl of 0.6% thiobarbituric acid is added and incubated at 95-100 ° C for 30minutes. The material will be read in a spectrophotometer at a wavelength of 532nm.

Measure: Oxidative stress (Malondialdehyde). The changes are being evaluated.

Time: The collections will be done 24 hours before, in the 6th week and 48 hours after the end of the intervention.

Description: 10 ml of blood will be collected in the beginning of the morning, with fasting of 10 to 12 hours, being done 24 hours before, in the 6th week and after the intervention period. Five milliliters of blood will be placed in test tubes containing EDTA and protected from light and the other 5ml will be placed in tubes without anticoagulants and centrifuged at 3,000 rpm for 10 min. The plasma or serum will be separated, placed in eppendorf tubes and refrigerated at -20 ° C until analyzed by a commercial kit of the Labtest brand (Minas Gerais, Brazil). The evaluation of the total antioxidant capacity will be performed through DPPH. For analysis, 100 μl of plasma will be added to 3.9 ml of vortexed DPPH solution, set to stand for 30 minutes and then centrifuged at 10,000 rpm for 15 minutes at 20 ° C. The supernatant will be used for spectrophotometer reading at 515 nm wavelength, using distilled white water. The result will be expressed as a percentage of antioxidant activity.

Measure: Oxidative stress (Total antioxidant capacity). The changes are being evaluated.

Time: The collections will be done 24 hours before, in the 6th week and 48 hours after the end of the intervention.

Description: 10 ml of blood will be collected in the beginning of the morning, with fasting of 10 to 12 hours, being done 24 hours before, in the 6th week and after the intervention period. Five milliliters of blood will be placed in test tubes containing EDTA and protected from light and the other 5ml will be placed in tubes without anticoagulants and centrifuged at 3,000 rpm for 10 min. The plasma or serum will be separated, placed in eppendorf tubes and refrigerated at -20 ° C until analyzed by a commercial kit of the Labtest brand (Minas Gerais, Brazil). The concentration of hs-CRP will be quantified by immunoturbidimetry in serum samples. Calibration will use the Calibra Calibrator from Labtest (Calibra Plus PCR-ultra - Ref-345). Absorbance will be obtained on the Labmax 240 premium automatic analyzer at 540 nm wavelength. The concentrations of hs-CRP will be determined by the commercial kit (Labtest, Minas Gerais, Brazil) according to the manufacturer's instructions.

Measure: Systemic Inflammation (Plasma ultra-sensitive C-reactive protein). The changes are being evaluated.

Time: The collections will be done 24 hours before, in the 6th week and 48 hours after the end of the intervention.

Description: 10 ml of blood will be collected in the beginning of the morning, with fasting of 10 to 12 hours, being done 24 hours before, in the 6th week and after the intervention period. Five milliliters of blood will be placed in test tubes containing EDTA and protected from light and the other 5ml will be placed in tubes without anticoagulants and centrifuged at 3,000 rpm for 10 min. The plasma or serum will be separated, placed in eppendorf tubes and refrigerated at -20 ° C until analyzed by a commercial kit of the Labtest brand (Minas Gerais, Brazil). The A1GPA concentration will be quantified by immunoturbidimetry using the commercial kit (Labtest, Minas Gerais, Brazil) as per manufacturer's instructions. Calibration will use the Calibra Calibrator from Labtest (Calibra Plus Protein - Ref-346). The absorbance will be obtained in the Labmax 240 premium automatic analyzer (Lagoa Santa-MG, Brazil), at wavelength 340nm.

Measure: Systemic Inflammation (Analysis of alpha-1-glycoprotein acid). The changes are being evaluated.

Time: The collections will be done 24 hours before, in the 6th week and 48 hours after the end of the intervention.

Description: Oral cell samples were collected through a mouthwash for 60 seconds of 5 ml of 3% sucrose solution. The resulting contents of the mouthwash were transferred to a 15 ml tube, which immediately afterwards was placed in a solution of TNE (17 mM Tris-HCl pH 8.0, 50 mM NaCl and 7 mM EDTA), diluted to 66% alcohol and autoclaved distilled water.After this, the extraction and genotyping process followed the recommendations of Saiki et al. (1985)

Measure: DNA Extraction and Genotyping

Time: The genetic collection will be made in the 6th week of the intervention.

Purpose: Treatment

Allocation: Randomized

Parallel Assignment


There is one SNP

SNPs


1 rs9939609

Influence of Genetic and Physiological in Weight Loss The study focuses on the influence of polymorphism in the FTO genes rs9939609 and PPARᵧ Pro12Ala, oxidative stress and systemic inflammation on changes in body composition and rest metabolism induced by HIIT and continuous aerobic programs in obese or overweight individuals.

Thus, the objective of the study is to analyze the influence of polymorphism in the genes FTO rs9939609 and PPARᵧ Pro12Ala, oxidative stress and systemic inflammation on changes in body composition and rest metabolism induced by continuous and continuous aerobic programs.



HPO Nodes


HPO:
Decreased body weight
Genes 1586
GPC3 ALG13 LETM1 UBR1 TGM1 NONO BIRC3 NACC1 ORC1 MYPN CYP11B2 NNT GRIN2A LMBRD1 INS GLI1 NDUFAF4 ORC4 SDHD NDUFB10 YWHAG MYH3 WDR4 NGLY1 SCN3A MARS1 TRMT10C TAC3 SELENON HSD11B2 TRAK1 DYNC2LI1 GABRG2 ASXL1 POLG CYP7B1 IGF1 PTDSS1 CYB5A CHEK2 ERCC5 HIRA GBE1 ALG9 CEP57 MCTP2 NRXN1 FLNA CD3G SGO1 ALDH18A1 SEMA3C SCNN1G BCOR HLA-DPB1 NDUFS1 PCLO MYH7 PET100 TRAIP RAB3GAP1 SSR4 IL10 ASS1 PSMD12 BMPR1A RAI1 MBTPS1 GPT2 MYH7 PIK3C2A MC2R CALR RAG2 B3GLCT NDUFAF2 COG6 JPH3 AGTPBP1 CLCN4 ITGB4 SDHC TPM2 TRPV4 TSHR NONO ACADS HERC2 CYP19A1 CD247 RNU4ATAC CYB5A SDHAF1 GTF2I CDC45 IGH MID2 CCNQ TXNRD2 SLC25A22 ATP6V0A2 COA8 RET VPS33B ERMARD NPAP1 RECQL4 MED12 SLC52A3 ND4 SDHA ND2 MED17 KCNJ6 SFTPB MRPL3 GATA6 FGFR1 BRCA1 TAZ CYP17A1 KRT14 ANOS1 LETM1 MAP2K2 NDUFB8 TRAK1 HAVCR2 SLC25A13 NHLRC2 COX15 MPI DCLRE1C TOP3A WWOX MED12 NDN KCNA2 COL1A2 MRAP NDUFA12 EWSR1 EDN3 COG4 TBL1XR1 SLC52A2 PACS1 COL6A2 POLR3A MAP2K1 TGFB1 CNKSR2 FGF12 TGFBR2 MTFMT ZAP70 TTR NTRK2 DSP HADHA RB1 GABRA3 SPATA5 NDUFAF1 TCOF1 KCNJ11 CDC45 GATA6 NDP TBR1 ATP6 CLTC DPM2 SLC25A13 NEUROG3 RAD51C RMRP SLC6A8 SYNJ1 DLD COL5A2 IL1RAPL1 BCL10 NDUFB3 CCR1 SON RTTN PDE6D STRA6 NSMF SLC25A15 FANCD2 ATP6V0A2 CPS1 KMT2D KIF15 TMEM70 STT3B RFC2 PTEN MCCC1 PKP1 NDUFS3 GATM LBR ATRIP TRNQ TRNN MCM9 ALG12 ATXN7 FANCI UMPS SCNN1B MKKS NSD2 CDON BSCL2 MAD2L2 AGTR2 ERCC3 ORC4 RFXANK COL6A2 HYMAI SCN2A NOD2 JAGN1 GPR35 FANCA ABL1 HLA-DPA1 NUP214 CD96 SLX4 RAG2 STAG2 KRT14 DPM1 TAPT1 PANK2 POLA1 FARSB FLNA DNAJC21 ADA JPH3 PPP2R3C SMC1A GHSR IL7R MICOS13 PRKACA SLC25A4 FUT8 SCNN1A CSF2RA NALCN CYP7B1 NSMCE3 ACAT1 ACTA1 ELN SLC10A2 RFX5 TIMM50 MTRR MLH3 NDUFV1 SMOC1 POLE SLC2A2 SKI TP53 VPS13B CAVIN1 KANSL1 ALPL IGHM SDHB CYP2R1 DGAT1 GBA SLC13A5 F5 WDR4 IGF1R RARS2 ND3 IPW POLG2 ERCC6 INS NDUFS7 BAAT EFL1 SLC9A6 ST3GAL5 DOLK DCTN1 ERAP1 SYP PRNP MSH6 KCNJ6 NOTCH1 PEX12 IGH DOCK6 ABCA3 SLC25A24 DMD LRRC8A BRAF MEGF10 POLR1C HNRNPH2 FTSJ1 KDM6A EVC CNTN1 CTLA4 CD79A AVPR2 BANF1 CDK10 TRNS1 SELENON H19 BRCA2 POLG2 NDUFS3 RIT1 AKT1 HLA-DRB1 IKBKB NSDHL NR1H4 ERCC5 DAXX TET2 MVK EOGT CDC73 PEX16 ND1 PIK3R1 SUCLA2 GABRA5 OCRL PDE8B PEX14 GNPAT PEX1 NKX2-1 TCF4 PEX2 SEMA4A PIK3CA FGFR1 FLII NDUFB8 GNPTAB PLA2G6 C4A NFIX UNC80 NFKB1 FANCC WRN IL2RG CNTNAP2 MEFV GYS2 PROKR2 CASK NEB ATP6V1A GBA MRPS2 EXT1 PMPCB PEX13 UBE2T GTPBP2 PEX1 ND5 SBDS CYP2R1 EIF2S3 BCOR COX15 RECQL4 ERCC2 DNA2 ARPC1B SPINK5 ERCC4 RAI1 PARS2 BRCA2 MCCC2 RNF168 IQSEC2 PEX12 TERT ERCC4 CASR NUBPL TCTN3 TMEM216 IRF2BP2 MMACHC KCNA1 LAMA2 ADK GRIA3 WT1 USP9X ERCC4 OCRL LRP5 VIPAS39 DNM1L PARN CASK HSD3B7 LAMC2 IFNGR1 CREB3L1 CDKL5 RFXAP MECP2 CAMKMT NDUFA11 ATP5F1A SLC11A1 SDHB ASAH1 SLC7A7 TRIM28 SELENON BRCA2 HLA-B NFU1 FIP1L1 NDUFS2 PROK2 DEGS1 PRF1 SERAC1 NDP IQSEC2 LCK MAP3K7 AHDC1 COL5A1 COX20 COG7 ADAR FANCI FAH KRT5 GALC TNFRSF13C SEC24C IL2RG CCND1 SIL1 NUMA1 ACSF3 SLC9A7 MIPEP RELB CA2 ZNF81 PRNP DCTN1 REST C12ORF65 HMGA2 PEX14 CORIN FANCA LAMB3 CD79B PEX6 PSAT1 PRDM16 ABCA12 LHX4 FOS PTF1A NDUFAF3 HADHA CYP17A1 GATA4 CAV1 FANCB RARB MMUT POLR3A GLYCTK COG1 RFT1 KRAS TACO1 MSX1 PRSS1 NOTCH2 GATA2 SKIV2L ATM RPL5 FASTKD2 NDUFA6 ALG13 GBA CACNA1S JAK3 INSR POLA1 PHOX2B CDC6 SLC25A24 COPB2 ALDOB CD3D CYB5R3 TRIM28 PSMB4 ARFGEF2 HPD GPR161 LEMD3 PTPN22 NR0B1 COX1 INSR SP110 CNTNAP1 STAR PCGF2 ACO2 COQ7 NDUFA13 CENPJ SLC5A1 FANCC SLC46A1 EVC2 RFT1 NDUFB9 LPIN2 NDUFB3 RREB1 TSHR MYL2 SIN3A PLAGL1 SCNN1B BTK NECTIN1 CFTR SCO1 HIBCH PDHA1 CD81 WDR60 RET FRMPD4 PLAA ALB COX10 NLRP1 ESR2 TMEM126B CDC6 ATP6V1E1 MAP3K20 EIF4G1 COX10 PHGDH PTPN11 TNFSF12 TPM2 FLT1 TSPAN7 ADA VPS35 MOGS CPLANE1 TUBB4A CLCNKB PRTN3 LARP7 DYRK1A ALOXE3 NDUFA1 NUP62 CSNK2A1 MPV17 RPS6KA3 NDUFA4 POLG TRNW ND6 ZNF41 HPD ABCC8 NFKB2 TRNV ND4 GNAS TERT UBA5 NDUFAF3 SLC25A13 LMBRD1 BPTF MSMO1 GBA CA12 TACO1 DLG3 ASCL1 TBX1 RBCK1 NADK2 GTF2IRD1 PEX16 PML ARX NDUFS7 LRRK2 MECP2 LAT LYRM7 UBA1 LARS1 PDE11A ATP6V0A2 FAM111A MCEE BMP4 SETD5 PIK3R1 AMER1 NDUFAF4 ORC6 GRIN2D CCDC47 ZFP57 ACD FBXL4 RPS6KA3 CAVIN1 JAK2 WNT2B CYP27B1 TALDO1 ZFP57 EPHX1 PPP1CB FANCE SDHD FANCM MAX IGHM SNAP29 KDM6A SLC22A5 KLHL41 IL12A PDHA1 PEX5 PEX26 EGFR PCNT ARID1B CYP11B2 PNP CR2 NCAPG2 TMEM165 ARHGEF6 ACADM RBM10 NDUFA13 SMAD4 IFIH1 NDUFB11 PEX3 TUBB4A CD19 IGHMBP2 ACADVL STAT3 PTPN22 TRIP13 AKT1 AARS1 DHDDS SDHC TTC37 RNF13 JAK2 PSMB9 NSD2 MAGEL2 PDX1 TRAC HIKESHI RRM2B OCLN NLRC4 FANCE DNA2 PEX5 RTTN RYR1 CPLX1 DCLRE1C SETBP1 FAM111A DCLRE1C MCCC2 IL7R NDUFA10 IL2RG CASP8 RAG1 PIK3CA AMPD2 LTC4S DNM2 NDUFAF5 TCF4 NDUFV1 KRAS IL6 GALT EPCAM SPR MAP2K1 SLC35A2 GDNF TRNL1 AKR1D1 SMC1A LIPT1 NDUFS8 ATM FBN1 DNAJC3 MBL2 STAT4 GRIA3 IKZF1 ATRX MKRN3-AS1 PEX7 CCND1 KCNJ10 RAD21 PEX19 GTF2E2 KLHL7 UBR1 ZNF335 NEB NAB2 SCO2 CPLANE1 NDUFA9 HLA-DRB1 MC2R CYP27B1 CDH23 EPCAM SLC6A8 PRNP PEX16 KISS1 SLC3A1 MMADHC SZT2 BCAP31 POR TMPRSS15 SRP54 NR3C2 ND3 ACTL6B ST3GAL5 DDB2 DGUOK MMUT PTEN AUH B3GALT6 SON KCNAB2 KCNB1 CUL4B ITGA7 NDUFS4 GCDH OBSL1 DNMT3B NFKB2 NUS1 CYP11A1 MPL PLAA SNCA AGPAT2 NDUFV2 HMBS ANTXR2 WDR11 SALL1 RMRP ZSWIM6 CFTR GABRA2 SLC25A11 SUCLA2 TIMMDC1 SNCA TGFB1 PCSK1 HMGCL YY1AP1 CYP24A1 IGF1 FZD4 PMM2 GCK SYNE1 OTUD6B WDR73 FBN2 GNAO1 HTT ACTG1 NDUFAF5 CBS CENPE ERCC4 SDHA NDUFV2 PREPL IRF6 FTO PPM1B DHCR24 IL2RB COX8A MMAB CEP152 GRIA4 ALG8 TRIM37 POLR1A GNPTAB PUF60 TRNF TBL1XR1 PEX5 EP300 COX14 ATPAF2 PNPLA6 KISS1R RBPJ STRADA PEX5 TRMT1 AP1B1 OTC PTEN SLC46A1 PTPRC ROBO1 ST3GAL5 SNORD115-1 NSUN2 ARVCF MST1 AQP2 TMEM127 MRPS7 PEX13 AMACR SDHA IGF2 PEX12 JMJD1C ACTB ND5 SLC25A3 HCFC1 AVP FCGR2A FLI1 HSD17B4 GPT2 TTC37 ATP7B HADHA NRTN BLNK KIAA0586 FOXP1 BUB1B HSD11B2 PEX2 TPM2 HLA-DRB1 PMS2 POMP NNT DUSP6 BCS1L STAT6 NGLY1 LRBA POLG ERCC4 ARCN1 EFL1 VHL EXOSC8 AUTS2 FANCD2 CACNA1B PEX10 CARMIL2 ND1 MSH2 SHROOM4 SPRTN POC1A MAP2K1 ZIC3 CLMP ALAD CENPJ STT3A NDUFAF5 SMPD1 WHCR GJB3 PEX11B SDHD KRAS RAI1 NPM1 AARS1 MYH3 RPS20 LAMB3 USP8 SYNGAP1 MPL COL1A1 PSMB8 HSPG2 NEXMIF PRKAR1A MECP2 GABRB2 MTR THRB ASL ABCC8 OTULIN PGM3 FANCL CLCNKA HLA-DRB1 COX3 RBM10 SLC12A1 SDHD UBE3B NUS1 HLA-B COX2 ARX SOX9 DNAJC21 TINF2 LIG4 POLR1D EEF1A2 RRM2B ERCC2 SSR4 BTNL2 SLC9A6 SLC34A3 CRIPT TRIM8 ACTB PTEN DLL4 ZBTB16 FOXRED1 HRAS HACD1 ERCC3 PPARG COX4I2 STAT5B G6PC3 SNORD116-1 AIMP1 DHDDS AK2 SCN8A MS4A1 MYH3 KCNA2 LIG4 LMNA PUS1 IGF2 PALLD STOX1 RFWD3 HYMAI HADHB LIPA RFXANK CDT1 TYMP HLA-B VDR RAP1A BMPR1A NDUFS4 TWNK SIK1 MECP2 SLC39A8 ORC1 GNRH1 PRPS1 PTS GJB4 EBP KIF7 EPG5 TET2 FLNA ADAT3 MRPS14 PEX3 BRCA1 LRPPRC SUGCT HLA-DQB1 ITCH SBDS FGFRL1 DNM1 COL6A3 BSND ACVR1 RAP1B CLDN16 ELN PYCR1 KMT2A MCM5 CIITA BCL2 FLCN PALB2 GMNN NAGS TGFB3 ORAI1 RAG2 PUS7 DIS3L2 ATP6 ETHE1 HDAC8 IL23R VPS13B SNX10 HCCS COG8 ANOS1 NOTCH2 B3GALT6 ND6 SLC39A4 STT3B WT1 COG1 TJP2 ADA DLST KBTBD13 DDX3X ZAP70 EPRS1 UFD1 EIF2AK3 STAT3 NEB NBN ECE1 NAGS TCIRG1 ATP8B1 B4GALT7 SDHAF2 LRP12 CASK ATP6V1A AP3B2 LMNA PEX13 EHMT1 KIF1B PNPO ARV1 SARS1 TFAM SDHC PRKAR1A MPDU1 UFC1 KRT1 CHRM3 CARS2 PEX11B SELENON BRCA1 AVPR2 RPS19 NAT8L ATP6V1A ARMC5 HCN1 SLC12A3 COX7B AHCY KMT2A MAGEL2 TMEM216 TMEM126B POLG VAC14 RAG1 KCNJ11 PWAR1 CYP11A1 AGPS PNPT1 TRNK ACOX1 PNKP XPA UBAC2 COL1A1 SDHB ATR RAG2 CNKSR2 FGF17 SCNN1A RFXAP ATP6V0A2 PET100 CTNS CXORF56 SMARCA2 STAMBP SARS2 PNPO MYMK RAB39B NDUFS2 XPC MMACHC EBP CSPP1 RTEL1 RRM2B JAK2 HCFC1 DCLRE1C COL12A1 STXBP1 DNAJC13 LYRM4 NFIX RBBP8 JAK2 TAF13 TYMP RFX5 PROKR2 MKRN3 GCK SCN3A SURF1 DHCR7 PTRH2 KCNA4 SLC19A3 DPP6 MPL CLCNKB UBA5 PEX19 TRIT1 HBA1 SURF1 MTO1 KDSR BCS1L GPC1 STT3A TSHR BMPR1A KRT5 COX6B1 SPRY4 ATP6V1E1 NOD2 FANCF CERS3 GJA1 ND2 SDHA DDOST PDX1 SURF1 IL12B MLXIPL BRAF CDH23 CLIP2 ASXL3 DHCR24 POU6F2 UBTF CTBP1 PDX1 INSR AGXT PAK3 SAMD9 AARS2 ELAC2 GNRHR NDUFS2 CIITA HS6ST1 SRP54 TP53 KCNJ18 TBL2 PLEC PTCHD1 DPYD STXBP1 SLC17A5 TRMT5 IL12A-AS1 THPO NABP1 FH FANCG DNAJC21 LMNA NDUFS1 HESX1 PNPLA1 AUH SFTPC SLC39A13 CD3E TCF3 SLC26A3 SEMA3D COMT SAR1B CDKN2A SKI POLG ERCC2 SLC7A7 CCDC8 TACR3 MGAT2 TRNH PEX10 PIEZO2 NDUFB11 EMG1 TP53 TRNL1 HUWE1 SLC25A15 KRAS KMT2A RAD51 NDUFS1 GABRD GP1BB SKIV2L VPS13A OSGEP KIAA0753 NDUFS4 ACAD9 CD96 CSF2RB EDNRB JAK3 DDOST IL21 TRNS1 BRAF ASXL1 IL7R GK XRCC2 KCNJ18 FIG4 TP63 INTU NIPBL RIN2 WT1 KCNJ1 SAR1B HSD3B7 ANKLE2 NDUFS6 SMAD4 ASAH1 GJA1 ATP6V0A4 COL6A1 CIT PLP1 BRCA2 TCF4 TRNW TGFB1 TIMMDC1 KLRC4 PLK4 KIF1B FOXRED1 ALG3 SMAD4 RBBP8 ACSF3 TTN XYLT2 COL6A1 CREBBP SIX2 NDUFAF2 RPS6KA3 NFE2L2 ETHE1 PRDX1 ERCC6 BAZ1B PAM16 ARHGAP31 COA8 ECHS1 KIF7 MED12 COL6A3 ERCC2 CKAP2L SMARCC2 RERE DACT1 BMP1 CHRNG FGF8 UBE3B AQP2 TIMM50 FAN1 PIGQ CDT1 ABCC8 NECAP1 SMC3 SUCLG1 AUTS2 RARA ALG11 PMM2 GNB1 ICOS TNFSF12 PWRN1 TRAIP MDH2 IL21R PIGP SLC39A4 PYGL CTNS PCCB NADK2 RIPK1 CYFIP2 PYCR2 SLC4A1 GMNN JAG1 TNFRSF13B DEAF1 FGFR1 COG8 NEUROD2 MAFB MRPS16 MCCC1 PTF1A FUCA1 NDUFS2 UPF3B OFD1 VPS37A VPS45 ERCC1 TPM3 FBN1 GNB1 TGFB1 CYP11B2 ELMO2 RAB33B ORC6 PEX26 RET ACTA1 COG4 HLCS GRIN2D SLC1A2 MUSK TCTN3 NSDHL TP53 KRT10 PREPL FAM149B1 TPM3 WDR11 ACTA1 DKC1 SETBP1 COL7A1 PIK3CA MBTPS2 FMR1 USP27X H19 KAT6B EARS2 PMS1 TCN2 TBX4 CHD7 FIG4 SNRPN NIPAL4 CACNA1S AHCY KCNJ11 PARN TK2 NDUFA2 RYR1 OTUD6B RAG1 MLH1 ACTB LMNA ASNS GDI1 RAG1 PEX1 CD79A TFRC CUL7 FOXP3 PPP1R15B RET EXOSC9 CD3D MMAA NDUFAF6 PEX2 TRNS2 LIPA BCL6 SLC34A1 TPM3 NELFA NPHS1 NDUFV2 HBA2 RHBDF2 IGLL1 POMC LIMK1 GALE NUP62 ABCB11 NDUFAF1 LAMA3 MDH2 GALT SC5D FAS CACNA1A TRIO ND1 TLR4 ACTA1 PRKCD LAMA3 SLC12A3 LAMC2 ZNF711 PPP3CA CHD7 IGH FH ALOX12B HADH GIGYF2 SMARCD2 PIK3R1 B2M STING1 KLLN SLC3A1 PEX6 PPP3CA ZMPSTE24 SEC23B NFASC BCAP31 HRAS GPIHBP1 EXT2 PEX19 HADHB MALT1 SCNN1G PALB2 BRIP1 NDUFB11 YARS2 TWIST2 SDHB PCCA TBC1D23 ACSL4 TBX1 FGD1 TGDS NDUFS8 IARS1 MLX
Weight loss
Genes 318
COL5A2 GPC3 MPL COL12A1 BCL10 BIRC3 CCR1 AK2 DNAJC13 SNCA ABCC8 LMNA ERCC4 RBBP8 JAK2 PALLD BRCA2 ND4 RFWD3 RNF168 TYMP HMBS HYMAI PTEN LIPA TYMP HLA-B SLC25A11 SUCLA2 SNCA ATRIP BMPR1A FAN1 TRNQ MPL IRF2BP2 HMGCL CYP24A1 WT1 PML ERCC4 FANCI GCK KDSR GJB4 LRRK2 MECP2 TSHR TET2 RARA HTT MAD2L2 ERCC3 CENPE IFNGR1 NOD2 COL6A2 FANCF SDHA TRAIP HLA-DQB1 NOD2 POLG MDH2 GPR35 FANCA CEP152 HLA-DPA1 IL12B SLX4 CHEK2 SLC11A1 SDHB ERCC5 TRIM37 TRIM28 COL6A3 CDH23 MAFB PANK2 BRCA2 HLA-B TRNF POU6F2 TBL1XR1 FIP1L1 SEMA3C BCL2 JAK2 NDP PALB2 JPH3 BCOR HLA-DPB1 ZFP57 HLCS TP53 FANCE IL10 KCNJ18 SDHD FANCM COL5A1 MAX DIS3L2 BMPR1A TP53 ACAT1 IL12A-AS1 THPO KRT10 IL12A NABP1 MC2R CALR IL23R MST1 FH FANCG PCNT MLH3 CCND1 JPH3 TMEM127 ND6 SLC39A4 NUMA1 WT1 SDHC SDHA ACADM ND5 AVP DLST SEMA3D TP53 TRPV4 TSHR FLI1 EIF2AK3 PMS1 SDHB CDKN2A STAT3 PRNP NBN POLG ECE1 DCTN1 REST CACNA1S SDHAF1 ATP7B KCNJ11 NRTN IGH F5 STAT3 PTPN22 TXNRD2 TRIP13 AKT1 FOXP1 JAK2 MLH1 TRNH HLA-DRB1 PMS2 SDHAF2 PDX1 INS LRP12 NNT SLC9A6 RRM2B FOXP3 DCTN1 ERAP1 TP53 SLC52A3 TRNL1 STAT6 PRNP GATA4 MSH6 RET KIF1B ERCC4 FANCB KRAS RAD51 IGH VHL FANCD2 VPS13A KRAS TRNS2 MSH2 BCL6 SDHC GATA2 EDNRB ATM PRKAR1A BRCA1 RHBDF2 PIK3CA KRT1 TRNS1 GBA CACNA1S INSR GJB3 SDHD CTLA4 NPM1 IL6 RPS20 BRCA1 XRCC2 KCNJ18 GALT H19 MPL HAVCR2 TRIM28 BRCA2 GDNF FAS COL1A1 WT1 HLA-DRB1 TLR4 PTPN22 HSPG2 COX1 STAT4 IKZF1 CNTNAP1 ATRX ABCC8 STAR DAXX MRAP CCND1 TET2 POLG EWSR1 CDC73 GJA1 EDN3 ND1 CENPJ NAB2 IGH LPIN2 FANCL SLC52A2 HLA-DRB1 TRNW HLA-DRB1 COX3 GIGYF2 SDHD PIK3R1 B2M EPCAM TCF4 PLAGL1 TGFB1 PRNP KLRC4 PLK4 KIF1B TGFBR2 SEMA4A SCNN1B UBAC2 BTK HLA-B COX2 CFTR SDHB ATR TTR GNPTAB PLA2G6 C4A RET SMAD4 SCNN1A ERCC2 UNC80 BTNL2 FANCC PTEN MALT1 SCNN1G PALB2 BRIP1 RB1 EIF4G1 MEFV GABRA3 CUL4B PTEN ZBTB16 KCNJ11 VPS35 COL6A1 PRTN3 RAD51C UBE2T RRM2B STAT5B SLC6A8 JAK2 MLX