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Report for Clinical Trial NCT03785821

Developed by Shray Alag, 2020.
SNP Clinical Trial Gene

Development and Clinical Application of Bitter Melon Seed Oil as a Functional Food for Treating Obesity and Hepatic Steatosis

To investigate the metabolic benefits of bitter melon seed oil (BMSO), overweight or obese healthy Taiwanese adults (n=60) were randomly assigned to receive capsules containing either olive oil (OO; placebo) or BMSO at 4.5 g/d dose for 12 week. Across intervention period, body weight, BMI, waist-to-hip ratio, and body fat mass were measured. Blood were collected before and after intervention for measurements of blood lipid and inflammatory cytokines. The anti-obesity effect of BMSO was further assessed by stratification of participants according to UCP1 rs1800592 polymorphism.

NCT03785821 Weight Gain
MeSH: Weight Gain
HPO: Increased body weight

2 Interventions

Name: BMSO

Description: BMSO was extracted from Hualien No. 4 cultivate of bitter melon seed. BMSO were incorporated into capsules containing 0.5 g of oil. All persons took 3 capsules after each meal, i.e. 9 capsules (4.5 g of oil) daily, resulting in daily consumption of 2.3 g alpha-ESA in the BMSO group.

Type: Dietary Supplement

BMSO

Name: OO

Description: Olive oil (extra virgin grade) was purchased from La Espanola (Acesur, Spain). OO were incorporated into capsules containing 0.5 g of oil, identical appearance to BMSO. All persons took 3 capsules after each meal, i.e. 9 capsules (4.5 g of oil) daily.

Type: Dietary Supplement

OO

Primary Outcomes

Description: Changes at intervention for 4,8 and 12 week

Measure: Weight gain

Time: 12 week

Secondary Outcomes

Description: Changes at intervention for 4,8 and 12 week

Measure: BMI

Time: 12 wk

Description: Changes at intervention for 4,8 and 12 week

Measure: waist-to hip ratio

Time: 12 wk

Description: Changes at intervention for 4,8 and 12 week

Measure: body fat mass

Time: 12 wk
Purpose: Prevention

Allocation: Randomized

Parallel Assignment

There is one SNP

SNPs

1 rs1800592

The anti-obesity effect of BMSO was further assessed by stratification of participants according to UCP1 rs1800592 polymorphism.

Considering UCP-1 played a pivotal role in anti-adiposity function of BMSO as demonstrated in animal studies, the anti-obesity effect of BMSO was further assessed according to UCP1 rs1800592 polymorphism.


HPO Nodes

HPO:
Increased body weight
Genes 513
MTMR14 PDE6A IDH3A ALG13 CANT1 PRKAR1A WDR34 PCARE EIF2S3 RP1 CTSH RAI1 PIGL LZTFL1 MTFMT TTC8 PPARG ANOS1 IQSEC2 IQSEC2 C8ORF37 TMEM67 RNPC3 MKRN3 FLRT3 MYT1L SNRNP200 BBS4 IFT172 CEP19 PROKR2 EMD EYS SLC25A4 LEPR KIDINS220 THOC2 PCSK1 PRPF4 ARL6 USP9X RDH12 IGF1 IFT172 ARL3 SOX10 PDE11A FGFR3 NR2E3 CUL4B RAB23 PAX6 ARL2BP DYRK1B GNAS GLI3 PRPF31 PNPLA6 SUFU PRCD RLBP1 FTO KLF11 TBX1 BLK INPP5E HIRA CYP7A1 TMEM43 DHDDS MEN1 BBS5 KCNJ11 MLXIPL LEP CLIP2 WNT4 IFT140 RP2 REEP6 TRIP4 EP300 FHL1 PDE4D SH2B1 CNGA1 CNNM2 PAK3 BRAF TNFSF4 IQSEC2 SDCCAG8 MOG TRAPPC9 SDC3 HLA-DQB1 TBL2 POMC ALMS1 PTCHD1 PRPH2 PSMD12 SH3KBP1 SNORD115-1 HSD11B1 ARVCF PRPF8 POMC GUCA1B ATRX SEC24C POMGNT1 ZNF365 SUFU ARMC5 CLCN4 HACE1 RBMX AP4E1 KIAA1549 SLC9A7 SH2B1 IFT27 GNAS EIF2S3 JMJD1C FGF17 COMT MKS1 ZNF81 HERC2 SKI CYP19A1 MKKS SOX2 ATP7B SLC7A7 GTF2I AKT2 MID2 SIM1 SMARCB1 DNMT3A ENPP1 PRPF6 ZNF408 PRDM16 FGFR1 PROM1 ERMARD BBS10 AIP HNF4A NPAP1 BEST1 GATA4 BBS1 ABCC8 TUB THOC2 P4HTM TBX3 KMT2A BBS7 GABRD GP1BB WDR11 RP9 AP4M1 GNAS XRCC4 IGSF1 PAX6 SDCCAG8 RBP3 ADRB3 GNAS PAX4 NSMF NPHP1 RAI1 ATP6AP2 GNAS-AS1 MTOR USP8 MAK KCNJ18 CCDC141 IMPDH1 PDSS1 NIPBL ADNP DPYD SETD2 NR0B2 MED12 NDN FAM161A HESX1 NRL BBS10 GHRL DUSP6 LAS1L PRKACA MKKS P2RY11 BBS5 MEGF8 ZNF711 RREB1 H6PD PIGA HESX1 SIN3A CNKSR2 KIDINS220 BBS12 FRMPD4 IFT74 TRIM32 BLK AFF4 POGZ ALB GABRA3 TSPAN7 SLC10A7 SYNE2 CREBBP GNAS RPS6KA3 ANK3 OFD1 IFT172 APC2 PRKAR1A RPGR BBS9 SNORD116-1 IL1RAPL1 OTX2 NSD1 HACE1 PCSK1 FGFR1 SETD2 BAZ1B EHMT1 UBE2A ZNF41 HNF1A EDNRB INS PROK2 POU3F4 IFT88 PDE6B GNAS ABCC8 RGR ARL13B KMT2D GHR GNAS NEK2 RFC2 CA4 LIPE RERE MAPK8IP3 RHO SCAPER THRA BPTF RAP1A DLG3 BBS9 PCNT LEP IGFALS CRB1 RPS6KA3 TBX1 NEUROD1 CEP164 GTF2IRD1 RAI1 SIM1 MECP2 FIBP ARX SMC3 PHIP TRIP12 DNM2 CARTPT NTRK2 HELLPAR HDAC8 AGTR2 SEMA3A BRAF AHR PWRN1 CFH OFD1 SETD5 ADNP LZTFL1 PROK2 ABCC8 KISS1R CEP290 MTOR HS6ST1 CDHR1 AP4B1 DEAF1 MAN1B1 RAP1B CTNNB1 TMCO1 USP8 BBS2 GCK UPF3B ELN MAN1B1 PTEN TRIM32 CFI MKS1 ROM1 AP4S1 BBS2 LEPR KCNJ11 MRAP2 PRPF3 CD46 PDGFB LRAT TRAF3IP1 HDAC8 SPRY4 ELN SRY FEZF1 VPS13B TACR3 KIF7 TAF1 RAB23 FOXP1 HDAC8 CERKL CLRN1 AGRP BBS2 MOG TOPORS ARNT2 ARHGEF6 FMR1 USP27X SHANK3 PIGN XYLT1 TP53 VPS13B SMAD4 UFD1 EGF UCP3 BBS12 IFT172 ABCC9 SNRPN CACNA1S USH2A HNF1A ACADVL ADRB2 MEGF8 C8ORF37 APOE WDPCP IGF1R CCDC141 NIN IPW MAGEL2 GDI1 NF2 HGSNAT ARL6 UCP2 HUWE1 PIGT RYR1 SEMA4A EHMT1 SYP IDH3B PRMT7 CEP290 PCNT SH2B1 HDAC4 ADCY3 TTC8 CHD7 AKT2 ABCA4 LMNA HCRT MC4R DMD ZNF513 BIN1 CRX SYNE1 XYLT1 BDNF TBX3 MC3R KLHL7 DCC SPG11 RNF135 TTC8 POMC ALMS1 FTSJ1 PDX1 KDM6A LIMK1 BBIP1 BBS7 RPE65 CCDC28B EXOC6B BBIP1 PTCH1 AHI1 ARMC5 AGBL5 PDE4D TULP1 SMC1A DHX38 CEL ARL6 MAGEL2 PROKR2 HLA-DRB1 MKRN3-AS1 SHOX RAD21 IMPG2 HNF4A ZNF711 C8ORF37 IFT27 PWAR1 MYF6 PNKP FGF8 DIS3L2 HNF4A CDH23 BBS1 WT1 GNAS MTTP ZBTB20 KIZ APPL1 FLII IL17RD SPATA7 MERTK KCNJ11 TCF20 MECP2 CXORF56 LMNA BBS4 SLC7A14 SOX3 MC4R LAS1L KCNAB2 CUL4B PDE6G ARHGEF18 SAG RAB39B STX16 UBE3A ACSL4 TBX1 MCM3AP TUB ATRX FSCN2 PHF6 TRAPPC9 PHF6 WT1 CNGB1 HCFC1