The purpose of this study is to identify gene variants that increase risk of cardiovascular disease (CVD) and type 2 diabetes, particularly genes related to stress factors.
Name: ZiprasidoneDescription: Given by mouth, single dose of 60 mg.Type: Drug
Name: LorcaserinDescription: Given by mouth, single dose of 20 mg.Type: Drug
Name: Placebo Oral TabletDescription: Given by mouth, single dose.Type: Drug
Placebo Oral Tablet
There is one SNP
Cardiovascular Diseases Cardiovascular Diseases In Aim 3, 100 subjects who participated in previous studies will be recruited to test the ability of a 5HTR2C agonist (lorcaserin) to increase and antagonist (ziprasidone) to reduce cortisol response to mental and metabolic stress in men carrying the rs6318 C allele and women in the rs6318 CC genotype of 5HTR2C.